ES8801273A1 - Un procedimiento para la preparacion de nuevos derivados de purina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de purina

Info

Publication number
ES8801273A1
ES8801273A1 ES553606A ES553606A ES8801273A1 ES 8801273 A1 ES8801273 A1 ES 8801273A1 ES 553606 A ES553606 A ES 553606A ES 553606 A ES553606 A ES 553606A ES 8801273 A1 ES8801273 A1 ES 8801273A1
Authority
ES
Spain
Prior art keywords
carbon atoms
hydrogen
alkyl
zero
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553606A
Other languages
English (en)
Other versions
ES553606A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/767,202 external-priority patent/US4772606A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES553606A0 publication Critical patent/ES553606A0/es
Publication of ES8801273A1 publication Critical patent/ES8801273A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE PURINA. CONSISTE EN CALENTAR A REFLUJO A UN COMPUESTO DE FORMULA (II) EN UN DISOLVENTE ALCOHOLICO (METANOL), Y EN PRESENCIA DE CARBONATO POTASICO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE. SIENDO: AR, HETEROARILO SUSTITUIDO CON ALQUILO DE C 1 A 4 Y OTROS; R, H O COR6; R1, OH; R2, H O NHR; R3, NHCOOR6; R4 Y R5 INDEPENDIENTEMENTE H, ALQUILO DE C 1 A 4, ARILO Y OTROS; R6, ALQUILO DE C 1 A 4; M, 0, 1, 2 O 3; Y N, 0 O 1. SE UTILIZA PARA EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES, COMO ARTRITIS, ENFERMEDADES INTESTINALES INFLAMATORIAS Y CANCER.
ES553606A 1984-10-12 1986-04-01 Un procedimiento para la preparacion de nuevos derivados de purina Expired ES8801273A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66015284A 1984-10-12 1984-10-12
US06/767,202 US4772606A (en) 1985-08-22 1985-08-22 Purine derivatives

Publications (2)

Publication Number Publication Date
ES553606A0 ES553606A0 (es) 1987-12-16
ES8801273A1 true ES8801273A1 (es) 1987-12-16

Family

ID=27097992

Family Applications (2)

Application Number Title Priority Date Filing Date
ES547805A Expired ES8609328A1 (es) 1984-10-12 1985-10-11 Un procedimiento para la preparacion de nuevos derivados de guanina.
ES553606A Expired ES8801273A1 (es) 1984-10-12 1986-04-01 Un procedimiento para la preparacion de nuevos derivados de purina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES547805A Expired ES8609328A1 (es) 1984-10-12 1985-10-11 Un procedimiento para la preparacion de nuevos derivados de guanina.

Country Status (15)

Country Link
EP (1) EP0178178A3 (es)
KR (1) KR860003255A (es)
AU (1) AU584126B2 (es)
CA (1) CA1260934A (es)
DK (1) DK458485A (es)
ES (2) ES8609328A1 (es)
FI (1) FI853891L (es)
GR (1) GR852468B (es)
HU (1) HU197747B (es)
IL (1) IL76546A (es)
NO (1) NO854050L (es)
NZ (1) NZ213798A (es)
OA (1) OA08120A (es)
PH (1) PH22811A (es)
PT (1) PT81293B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
DE69031337T2 (de) * 1989-02-27 1998-03-05 Biocryst 9-substituierte-8-unsubstituierte-9-deazaguanine
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5217983A (en) * 1992-03-27 1993-06-08 Du Pont Merck Pharmaceutical Company (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories
US5272169A (en) * 1992-03-27 1993-12-21 The Dupont Merck Pharmaceutical Company (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories
JPH10507171A (ja) * 1994-10-05 1998-07-14 カイロサイエンス・リミテッド Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
DE19501482A1 (de) * 1995-01-19 1996-07-25 Bayer Ag 2,9-disubstituierte Purin-6-one
GB9520364D0 (en) * 1995-10-05 1995-12-06 Chiroscience Ltd Compouundds
GB9520363D0 (en) * 1995-10-05 1995-12-06 Chiroscience Ltd Compounds
DE19541264A1 (de) * 1995-11-06 1997-05-07 Bayer Ag Purin-6-on-derivate
EP2336133A1 (en) 2001-10-30 2011-06-22 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
BRPI0414533A (pt) 2003-09-18 2006-11-07 Conforma Therapeutics Corp composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
CA2602257A1 (en) * 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
EP2773207B1 (en) * 2011-10-31 2018-03-07 Merck Sharp & Dohme Corp. Aminopyrimidinones as interleukin receptor-associated kinase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2844578A (en) * 1955-09-14 1958-07-22 Du Pont Pyrimidine derivatives

Also Published As

Publication number Publication date
NO854050L (no) 1986-04-14
HUT40131A (en) 1986-11-28
DK458485A (da) 1986-04-13
FI853891L (fi) 1986-04-13
NZ213798A (en) 1989-01-06
IL76546A (en) 1988-12-30
ES553606A0 (es) 1987-12-16
ES8609328A1 (es) 1986-09-01
CA1260934A (en) 1989-09-26
KR860003255A (ko) 1986-05-21
IL76546A0 (en) 1986-02-28
PH22811A (en) 1988-12-27
EP0178178A3 (en) 1987-08-12
EP0178178A2 (en) 1986-04-16
PT81293B (pt) 1988-02-17
HU197747B (en) 1989-05-29
FI853891A0 (fi) 1985-10-07
ES547805A0 (es) 1986-09-01
DK458485D0 (da) 1985-10-08
AU584126B2 (en) 1989-05-18
OA08120A (fr) 1987-03-31
AU4829285A (en) 1986-04-17
PT81293A (en) 1985-11-01
GR852468B (es) 1986-02-12

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