ES8708225A1 - Procedimiento para preparar nuevos compuestos de benzotiofe-no y benzofurano - Google Patents

Procedimiento para preparar nuevos compuestos de benzotiofe-no y benzofurano

Info

Publication number
ES8708225A1
ES8708225A1 ES549769A ES549769A ES8708225A1 ES 8708225 A1 ES8708225 A1 ES 8708225A1 ES 549769 A ES549769 A ES 549769A ES 549769 A ES549769 A ES 549769A ES 8708225 A1 ES8708225 A1 ES 8708225A1
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
amino group
compounds
arylsulphinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549769A
Other languages
English (en)
Other versions
ES549769A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/790,664 external-priority patent/US4703053A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES549769A0 publication Critical patent/ES549769A0/es
Publication of ES8708225A1 publication Critical patent/ES8708225A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS COMPUESTOS DE BENZOTIOFENO. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON 5-AMINO TETRAZOL, EN PRESENCIA DE UN AGENTE DE COPULACION COMO 1,1-CARBONILBIS (1-H-IMIDAZOL), EN TETRAHIDROFURANO Y A LA TEMPERATURA DE REFLUJO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R ELEVADO A 1, R ELEVADO A 4 Y R ELEVADO A 5, ALQUILO DE C 1 A 12, ALCOXI DE C 1 A 12 Y OTROS; R CUADRADO, ALCOXI DE C1 A 12, AMINO Y OTROS; R CUBO, RADICAL DE FORMULA (III); Y X, S. SE UTILIZAN COMO ANTIALERGICOS. *FORMULA*
ES549769A 1984-12-10 1985-12-10 Procedimiento para preparar nuevos compuestos de benzotiofe-no y benzofurano Expired ES8708225A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68010884A 1984-12-10 1984-12-10
US06/790,664 US4703053A (en) 1985-10-28 1985-10-28 Benzothiophenes and benzofurans and antiallergic use thereof

Publications (2)

Publication Number Publication Date
ES549769A0 ES549769A0 (es) 1987-10-01
ES8708225A1 true ES8708225A1 (es) 1987-10-01

Family

ID=27102392

Family Applications (3)

Application Number Title Priority Date Filing Date
ES549769A Expired ES8708225A1 (es) 1984-12-10 1985-12-10 Procedimiento para preparar nuevos compuestos de benzotiofe-no y benzofurano
ES557333A Expired ES8802453A1 (es) 1984-12-10 1987-01-16 Procedimiento para preparar nuevos compuestos de benzofurano
ES557334A Expired ES8801284A1 (es) 1984-12-10 1987-01-16 Procedimiento para preparar nuevos compuestos de benzotiofeno y benzofurano

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557333A Expired ES8802453A1 (es) 1984-12-10 1987-01-16 Procedimiento para preparar nuevos compuestos de benzofurano
ES557334A Expired ES8801284A1 (es) 1984-12-10 1987-01-16 Procedimiento para preparar nuevos compuestos de benzotiofeno y benzofurano

Country Status (17)

Country Link
EP (1) EP0187487B1 (es)
JP (1) JPH0819125B2 (es)
KR (1) KR890000009B1 (es)
CN (1) CN1007153B (es)
AU (1) AU579291B2 (es)
CA (1) CA1261848A (es)
DE (1) DE3579434D1 (es)
DK (1) DK169326B1 (es)
ES (3) ES8708225A1 (es)
FI (1) FI80691C (es)
GR (1) GR852949B (es)
HK (1) HK77393A (es)
IE (1) IE58555B1 (es)
NO (1) NO165592C (es)
NZ (1) NZ214479A (es)
PT (1) PT81636B (es)
SG (1) SG59593G (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US4748183A (en) * 1986-06-13 1988-05-31 Warner-Lambert Company N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof
EP0253650A3 (en) * 1986-07-18 1989-09-13 Eli Lilly And Company Improvements relating to benzothiophene derivatives
US4800211A (en) * 1986-08-18 1989-01-24 Merck & Co., Inc. 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors
US4910317A (en) * 1987-07-14 1990-03-20 Warner-Lambert Company Benzofurans and benzothiophenes having antiallergic activity and method of use thereof
IE64995B1 (en) * 1987-07-14 1995-09-20 Warner Lambert Co Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
AT387966B (de) * 1987-10-08 1989-04-10 Warner Lambert Co Neue n-1h-tetrazol-5-yl-(5-ring)-carboxamidderivate sowie verwendung derartiger verbindungen
US5093351A (en) * 1989-01-05 1992-03-03 Du Pont Merck Pharmaceutical Company Substituted indole, benzofuran and benzothiophene derivatives as 5-lipoxygenase inhibitors
IT1228893B (it) * 1989-02-24 1991-07-09 Valeas Spa Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche
DE4126999A1 (de) * 1991-08-16 1993-02-18 Basf Ag Herbizide mittel, enthaltend 3-aminobenzo(b)thiophene als antidots
DE4128871A1 (de) * 1991-08-30 1993-03-04 Boehringer Mannheim Gmbh Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel
US5426191A (en) * 1993-12-03 1995-06-20 Warner-Lambert Company Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides
JP2006526608A (ja) * 2003-06-05 2006-11-24 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー Ｐｉ３ｋ活性を有する治療薬としてのテトラゾールベンゾフランカルボキシアミド
JP2006526606A (ja) * 2003-06-05 2006-11-24 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 治療薬としてのシクロアルキル及びヘテロシクロアルキル置換されるベンゾチオフェン
ATE365735T1 (de) * 2003-06-05 2007-07-15 Warner Lambert Co Cycloalkylsulfanyl-substituierte benzo böthiophene als therapeutische mittel
MXPA05012953A (es) * 2003-06-05 2006-02-13 Warner Lambert Co Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos.
EP1664037A1 (en) * 2003-09-04 2006-06-07 Warner-Lambert Company Llc Halo substituted benzo [b] thiophenes with pi3k inhibitory activity as therapeutic agents
EP4213832A4 (en) * 2020-09-18 2024-10-16 Merck Sharp & Dohme Llc MODIFIED BENZOFURANCARBOXAMIDES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452039A (en) * 1966-05-25 1969-06-24 Bristol Myers Co Certain 5-tetrazolyl benzothiophene compounds
US4432986A (en) * 1979-06-18 1984-02-21 Riker Laboratories, Inc. Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
GB8406906D0 (en) * 1984-03-16 1984-04-18 Akzo Nv Benzo-thiazole and benzothiophene derivatives
FR2584723B1 (fr) * 1985-07-09 1988-02-12 Adir Nouveaux derives du dihydro-2,3 benzofuranne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP0187487A1 (en) 1986-07-16
CN1007153B (zh) 1990-03-14
DK169326B1 (da) 1994-10-10
FI854854A (fi) 1986-06-11
EP0187487B1 (en) 1990-08-29
FI854854A0 (fi) 1985-12-09
KR860004885A (ko) 1986-07-14
AU5050585A (en) 1986-06-19
FI80691C (fi) 1990-07-10
SG59593G (en) 1993-07-09
NO854942L (no) 1986-06-11
ES557333A0 (es) 1988-06-01
FI80691B (fi) 1990-03-30
PT81636B (pt) 1988-02-17
KR890000009B1 (ko) 1989-03-02
CA1261848A (en) 1989-09-26
AU579291B2 (en) 1988-11-17
IE58555B1 (en) 1993-10-06
DK568685D0 (da) 1985-12-09
NZ214479A (en) 1989-08-29
ES549769A0 (es) 1987-10-01
NO165592B (no) 1990-11-26
HK77393A (en) 1993-08-06
DE3579434D1 (de) 1990-10-04
IE852844L (en) 1986-06-10
ES8802453A1 (es) 1988-06-01
CN85109587A (zh) 1986-12-17
PT81636A (en) 1986-01-01
ES8801284A1 (es) 1987-12-16
JPH07149763A (ja) 1995-06-13
GR852949B (es) 1986-04-10
ES557334A0 (es) 1987-12-16
NO165592C (no) 1991-03-06
JPH0819125B2 (ja) 1996-02-28
DK568685A (da) 1986-06-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070630