ES8703871A1 - Procedimiento de obtener alcaloides del tipo de la berberina y similares. - Google Patents

Procedimiento de obtener alcaloides del tipo de la berberina y similares.

Info

Publication number
ES8703871A1
ES8703871A1 ES522754A ES522754A ES8703871A1 ES 8703871 A1 ES8703871 A1 ES 8703871A1 ES 522754 A ES522754 A ES 522754A ES 522754 A ES522754 A ES 522754A ES 8703871 A1 ES8703871 A1 ES 8703871A1
Authority
ES
Spain
Prior art keywords
decrease
composition containing
protoberberine alkaloid
containing same
left ventricle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522754A
Other languages
English (en)
Other versions
ES522754A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES522754A0 publication Critical patent/ES522754A0/es
Publication of ES8703871A1 publication Critical patent/ES8703871A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ALCALOIDES DEL TIPO DE LA BERBERINA Y SIMILARES, EN PARTICULAR, EN LA PREPARACION DE COMPUESTOS DE FORMULA GENERAL (I). COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE SOMETEN LOS PRECURSORES A UNA ETAPA DE SINTESIS; SEGUNDA, SE EFECTUA UNA ETAPA DE DISOLUCION DEL ALCALOIDE Y UNA ETAPA DE AJUSTE DEL PH PARA LLEVARLO A UN VALOR INFERIOR A 7; TERCERA, SE HACE REACCIONAR UNA DISOLUCION DE SULFATO DE BERBERINA CON HIDROXIDO DE BARIO; Y POR ULTIMO, SE TRATA LA DISOLUCION DE LA BASE LIBRE, FUERTEMENTE ALCALINA, CON HIDROXIDO SODICO, PARA OBTENER EL ALDEHIDO. DE APLICACION EN EL TRATAMIENTO Y DIAGNOSTICO DE LOS DESORDENES CIRCULATORIOS.
ES522754A 1982-05-14 1983-05-14 Procedimiento de obtener alcaloides del tipo de la berberina y similares. Expired ES8703871A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37812282A 1982-05-14 1982-05-14
US40988382A 1982-08-20 1982-08-20

Publications (2)

Publication Number Publication Date
ES522754A0 ES522754A0 (es) 1987-03-16
ES8703871A1 true ES8703871A1 (es) 1987-03-16

Family

ID=27008080

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522754A Expired ES8703871A1 (es) 1982-05-14 1983-05-14 Procedimiento de obtener alcaloides del tipo de la berberina y similares.

Country Status (11)

Country Link
EP (1) EP0108147B1 (es)
AU (1) AU571184B2 (es)
CA (1) CA1220139A (es)
DE (1) DE3377695D1 (es)
ES (1) ES8703871A1 (es)
GR (1) GR79223B (es)
IE (1) IE55519B1 (es)
IL (1) IL68690A0 (es)
IT (1) IT1173712B (es)
PT (1) PT76690B (es)
WO (1) WO1983003970A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100258849B1 (ko) * 1998-04-24 2000-08-01 박원배 약학적으로 유용한 프로토베르베린염 유도체 및프로토베르베린유도체와 이의 염
CA2467774C (en) 2001-11-14 2011-09-20 Rutgers, The State University Solubilized topoisomerase poisons
DE60225943T2 (de) 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase-giftmittel
EP1453507B1 (en) 2001-11-14 2009-03-04 Rutgers, The State University Solubilized topoisomerase poison agents
ATE405568T1 (de) 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
WO2004014906A2 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
JP4774212B2 (ja) 2002-11-12 2011-09-14 ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー トポイソメラーゼ−ターゲッティング剤
CN100441183C (zh) * 2005-08-29 2008-12-10 中国医学科学院皮肤病研究所 盐酸13-己基小檗碱和盐酸13-己基巴马汀制备治疗湿疹、皮炎和银屑病的药物用途
JP5773888B2 (ja) 2009-03-06 2015-09-02 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体
WO2010104595A1 (en) * 2009-03-11 2010-09-16 Xintria Pharmaceutical Corporation, Inc. Methods and compositions for the treatment of metabolic and cardiovascular disorders
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US20140107505A1 (en) * 2012-10-11 2014-04-17 Alon Marmor Determination of ventricular pressure and related values
CA3019945A1 (en) 2016-04-04 2017-10-12 Rutgers, The State University Of New Jersey Topoisomerase poisons

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129028C (es) * 1964-02-13
US3420834A (en) * 1964-11-13 1969-01-07 Roussel Uclaf 2,3-dimethoxy-berbines substituted in the 10 position and process
JPS4942700A (es) * 1972-08-25 1974-04-22
US3920665A (en) * 1972-10-19 1975-11-18 Kanebo Ltd Berbine compounds
JPS523397B2 (es) * 1972-11-20 1977-01-27
US3910938A (en) * 1973-01-27 1975-10-07 Kanebo Ltd Berbine derivatives
US4042592A (en) * 1974-05-08 1977-08-16 Kanebo, Ltd. Novel dibenzo[a,g]quinolizinium compounds
US4087426A (en) * 1976-08-16 1978-05-02 Research Corporation Oxybisberberine and a process for its production
SE426548B (sv) * 1978-12-05 1983-01-31 Haessle Ab Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer

Also Published As

Publication number Publication date
IL68690A0 (en) 1983-09-30
IE55519B1 (en) 1990-10-10
PT76690A (en) 1983-06-01
IE831098L (en) 1983-11-14
AU1706383A (en) 1983-12-02
IT8348294A0 (it) 1983-05-13
EP0108147A4 (en) 1984-09-13
IT1173712B (it) 1987-06-24
GR79223B (es) 1984-10-22
PT76690B (en) 1986-03-19
WO1983003970A1 (en) 1983-11-24
DE3377695D1 (en) 1988-09-22
ES522754A0 (es) 1987-03-16
AU571184B2 (en) 1988-04-14
CA1220139A (en) 1987-04-07
EP0108147A1 (en) 1984-05-16
EP0108147B1 (en) 1988-08-17

Similar Documents

Publication Publication Date Title
ES8703871A1 (es) Procedimiento de obtener alcaloides del tipo de la berberina y similares.
JPS5272379A (en) Separation of fluid
ES8801276A1 (es) Procedimiento para preparar nuevos derivados imidazo
GB1514720A (en) Preparation of hydroxyethyl starch
JPS5441191A (en) Glucose-oxygen sensitive electrode
JPS57134419A (en) Stable anticoagulant of blood
Jones et al. Effect of protamine on plasma ionized calcium in the dog
NZ217592A (en) Cardioplegia-inducing pharmaceutical composition containing potassium ions facilitated by adenosine
JPS54138126A (en) Remedy for diabetes
ES473534A1 (es) Procedimiento para la preparacion de analogos de prostaci- clina
JPS57116017A (en) Antithrombogenetic or anticoagulative agent
AU2169677A (en) Medicament to be taken orally for regulating the circulation of blood
Beavers et al. Relationship of potassium and calcium to hypothermic ventricular fibrillation
JPS579787A (en) Thiazinobenzimidazole derivative and its preparation
GB1520248A (en) Sodium cromoglycate containing medicament
Knudsen et al. The Effect On Serum-Thromboxan B2 Production, Platelet Aggregation, Serotonin Release, PF-4 And 6-Keto-PGF1αOf A Novel Specific Thromboxan A2 Synthetase-Inhibitor In Patients With Hyperactive Platelets
Dejana et al. Stimulation of prostacyclin release by a new vasodilatory coumarin derivative (AD6)
JPS57108016A (en) Antithrombotic agent
Ohata et al. Carotid baroreceptor influences on peripheral circulatory and thermal responses during cold exposure
JPS56100719A (en) Antirheumatic agent
JPS53127834A (en) Anti-tumor preparation
Carreras et al. Reduced Production Of 6-Ket0-PGF1α By Umbilical Artery In Pre-Eclampsia
Thandroyen et al. Combined α-and β-adrenoceptor antagonism protects against reperfusion ventricular arrhythmias
FR2259823A1 (en) N-beta-hydroxyethyl aziridines and iminothiazolidines prepn. - by redn. of ketones with bis-alkoxy sodium aluminium dihydride
JPS57108014A (en) Antithrombotic agent