ES8609194A1 - Un procedimiento para la resolucion optica de mezclas race- micas de acidos alfa-naftil propionicos - Google Patents

Un procedimiento para la resolucion optica de mezclas race- micas de acidos alfa-naftil propionicos

Info

Publication number
ES8609194A1
ES8609194A1 ES549118A ES549118A ES8609194A1 ES 8609194 A1 ES8609194 A1 ES 8609194A1 ES 549118 A ES549118 A ES 549118A ES 549118 A ES549118 A ES 549118A ES 8609194 A1 ES8609194 A1 ES 8609194A1
Authority
ES
Spain
Prior art keywords
formula
alpha
diasteroisomeric
amide
optical resolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549118A
Other languages
English (en)
Other versions
ES549118A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Chemicals Italiana SpA
Original Assignee
Alfa Chemicals Italiana SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Chemicals Italiana SpA filed Critical Alfa Chemicals Italiana SpA
Publication of ES8609194A1 publication Critical patent/ES8609194A1/es
Publication of ES549118A0 publication Critical patent/ES549118A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/12—Saturated polycyclic compounds
    • C07C61/125—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system
    • C07C61/13—Saturated polycyclic compounds having a carboxyl group bound to a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Detergent Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Treatment Of Sludge (AREA)
  • Fertilizers (AREA)
  • Indole Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA RESOLUCION OPTICA DE MEZCLAS RACEMICAS DE ACIDOS ALFA-NAFTIL PROPIONICOS. CONSISTE EN HACER REACCIONAR UN SUSTRATO SUSTANCIALMENTE RACEMICO DE FORMULA (II) CON UNA SUSTANCIA DE FORMULA R4-NH2, EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE Y DE UN AGENTE ALCALINO, A TEMPERATURA ENTRE LA AMBIENTE Y LA DE EBULLICION DE LA MEZCLA REACCIONAL, PARA OBTENER UN PAR DE AMIDAS DIASTEROISOMERICAS DE FORMULA (III); RESOLVER EL PAR DE AMIDAS EN UNA SOLA AMIDA DIASTEROISOMERICA CALENTANDO ENTRE 30 MINUTOS Y 12 HORAS Y LUEGO HACER DESCENDER GRADUALMENTE LA TEMPERATURA PARA AYUDAR A LA CRISTALIZACION, DE MODO QUE SE RECUPERA LA AMIDA DIASTEROISOMERICA DESEADA SIMPLE; Y SOMETER LA AMIDA RECUPERADA A HIDROLISIS DE ACIDO PARA OBTENER ACIDOS ALFA-NAFTIL PROPIONICOS DE FORMULA (I) DONDE R1 ES UN RADICAL DE ALQUILO Y R2 UN ATOMO DE H O HALOGENO. TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD COMO ANTIINFLAMATORIO.
ES549118A 1984-11-22 1985-11-21 Un procedimiento para la resolucion optica de mezclas race- micas de acidos alfa-naftil propionicos Expired ES8609194A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23689/84A IT1196334B (it) 1984-11-22 1984-11-22 Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici

Publications (2)

Publication Number Publication Date
ES8609194A1 true ES8609194A1 (es) 1986-09-01
ES549118A0 ES549118A0 (es) 1986-09-01

Family

ID=11209167

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549118A Expired ES8609194A1 (es) 1984-11-22 1985-11-21 Un procedimiento para la resolucion optica de mezclas race- micas de acidos alfa-naftil propionicos

Country Status (20)

Country Link
US (1) US4622419A (es)
EP (1) EP0182279B1 (es)
JP (2) JPS61129148A (es)
KR (1) KR860004003A (es)
AT (1) ATE50558T1 (es)
AU (1) AU591880B2 (es)
CA (2) CA1264765A (es)
DE (2) DE3576152D1 (es)
DK (1) DK537485A (es)
ES (1) ES8609194A1 (es)
FI (1) FI83074C (es)
GR (1) GR852798B (es)
HU (2) HU910941D0 (es)
IL (1) IL76952A (es)
IT (1) IT1196334B (es)
NO (1) NO162815C (es)
NZ (1) NZ214137A (es)
PT (1) PT81530B (es)
YU (1) YU45288B (es)
ZA (1) ZA858383B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU611699B2 (en) * 1987-07-31 1991-06-20 American Home Products Corporation Naphthalene propionic acid derivatives
US4937373A (en) * 1988-12-08 1990-06-26 Hoffmann-La Roche Inc. Substituted naphthalene carboxylic acids
US5196575A (en) * 1992-02-19 1993-03-23 Hoechst Celanese Corp. Supercritical separation of isomers of functional organic compounds at moderate conditions
IT1271800B (it) * 1994-12-27 1997-06-09 Zambon Spa Processo di preparazione degli enantiomeri dell'acido 2- (2-fluoro- 4-bifenil) propionico
DE19624604A1 (de) * 1996-06-20 1998-01-02 Hoechst Ag Verfahren zur Herstellung chiraler, nicht racemischer (4-Aryl-2,5-dioxoimidazolidin-1-yl)essigsäuren
US5936118A (en) * 1997-04-04 1999-08-10 Albemarle Corporation Process for chiral enrichment of optically active carboxylic acids or salts or esters thereof
WO2005040766A1 (de) * 2003-10-27 2005-05-06 Holzindustrie Leitinger Gesellschaft M.B.H. Verfahren zur qualitätssicherung von langholz
EP1589019B1 (de) * 2004-04-20 2008-08-13 Ratiopharm GmbH Stereoselektives Verfahren zur Herstellung von Clopidogrel
USD815946S1 (en) 2016-04-25 2018-04-24 Piramal Glass-Usa, Inc. Bottle

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683015A (en) * 1970-11-04 1972-08-08 Norman H Dyson Resolution of 2-(6-methoxy-2-naphthyl)propionic
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
JPS569514A (en) * 1979-07-02 1981-01-31 Hiroomi Makita Method of and apparatus for filling back soil and compaction by soil improving machine
JPS5822139B2 (ja) * 1979-12-28 1983-05-06 日清製粉株式会社 ｄｌ−２−（６−メトキシ−２−ナフチル）−プロピオン酸の光学分割法
IT1154663B (it) * 1980-07-30 1987-01-21 Alfa Chimica Italiana Spa Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico
FI831820L (fi) * 1982-05-27 1983-11-28 Syntex Pharma Int Foerfarande foer framstaellning av d-2-(6-metoxi-2-naftyl)-propionsyra och dess farmaceutiskt godtagbara salter samt av nya mellanprodukter anvaenda vid deras framstaellning
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici

Also Published As

Publication number Publication date
NO162815C (no) 1990-02-21
AU5025685A (en) 1986-05-29
ATE50558T1 (de) 1990-03-15
FI854596A (fi) 1986-05-23
DK537485A (da) 1986-05-23
AU591880B2 (en) 1989-12-21
NO854659L (no) 1986-05-23
YU179585A (en) 1987-12-31
DE182279T1 (de) 1987-05-21
HUT40065A (en) 1986-11-28
HU910941D0 (en) 1991-10-28
JPS61129148A (ja) 1986-06-17
FI83074B (fi) 1991-02-15
EP0182279B1 (en) 1990-02-28
PT81530A (en) 1985-12-01
IL76952A (en) 1989-12-15
DK537485D0 (da) 1985-11-21
CA1264765A (en) 1990-01-23
NO162815B (no) 1989-11-13
FI854596A0 (fi) 1985-11-21
IT8423689A0 (it) 1984-11-22
IT1196334B (it) 1988-11-16
US4622419A (en) 1986-11-11
FI83074C (fi) 1991-05-27
KR860004003A (ko) 1986-06-16
JPH05246967A (ja) 1993-09-24
NZ214137A (en) 1989-07-27
PT81530B (pt) 1987-11-11
ES549118A0 (es) 1986-09-01
HU204247B (en) 1991-12-30
CA1276177C (en) 1990-11-13
DE3576152D1 (de) 1990-04-05
ZA858383B (en) 1986-06-25
EP0182279A1 (en) 1986-05-28
GR852798B (es) 1986-03-19
YU45288B (en) 1992-05-28

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506