ES8606885A1 - Un procedimiento para la produccion de un polipeptido - Google Patents

Un procedimiento para la produccion de un polipeptido

Info

Publication number
ES8606885A1
ES8606885A1 ES536027A ES536027A ES8606885A1 ES 8606885 A1 ES8606885 A1 ES 8606885A1 ES 536027 A ES536027 A ES 536027A ES 536027 A ES536027 A ES 536027A ES 8606885 A1 ES8606885 A1 ES 8606885A1
Authority
ES
Spain
Prior art keywords
immune interferon
interferon fragment
fragment
homogeneous immune
homogeneous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536027A
Other languages
English (en)
Other versions
ES536027A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES536027A0 publication Critical patent/ES536027A0/es
Publication of ES8606885A1 publication Critical patent/ES8606885A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Tires In General (AREA)
  • Detergent Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE UN POLIPEPTIDO. COMPRENDE: A) SONIFICAR O LISAR MECANICAMENTE A LAS CELULAS DE MICROORGANISMOS TRANSFORMADOS; B) EXTRAER EL SONIFICADO, EN AUSENCIA DE UN INHIBIDOR DE PROTEASA PARA DAR UN EXTRACTO; Y C) PURIFICAR AL EXTRACTO CON ANTICUERPOS MONOCLONALES CONTRA EL INTERFERON HUMANO, PARA PRODUCIR UN POLIPEPTIDO CON UNA SECUENCIA DE AMINOACIDOS DE FORMULA (I) QUE TIENE METIONINA ADICIONAL. LOS MICROORGANISMOS TRANSFORMADOS EXPRESAN IFN-G, Y SE ELIGEN ENTRE LA ESCHERICHIA COLI K-12 CEPA 294 Y ESCHERICHIA COLI MA210 Y LA ESCHERICHIA COLI RR1 ''ATCC N.O 31343). EL EXTRACTO ES RIFN-G Y EL ANTICUERPO MONOCLONADO ES (MOG2-11,1). SE UTILIZA EN LA PROFILAXIS O TRATAMIENTO DE TRASTORNOS VIRALES O NEOPLASTICOS.
ES536027A 1983-09-20 1984-09-19 Un procedimiento para la produccion de un polipeptido Expired ES8606885A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/534,038 US4604284A (en) 1983-09-20 1983-09-20 Homogeneous immune interferon fragment

Publications (2)

Publication Number Publication Date
ES536027A0 ES536027A0 (es) 1986-05-16
ES8606885A1 true ES8606885A1 (es) 1986-05-16

Family

ID=24128463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536027A Expired ES8606885A1 (es) 1983-09-20 1984-09-19 Un procedimiento para la produccion de un polipeptido

Country Status (20)

Country Link
US (1) US4604284A (es)
EP (1) EP0136620B1 (es)
JP (1) JPS6163697A (es)
KR (1) KR850002283A (es)
AT (1) ATE31933T1 (es)
AU (1) AU577314B2 (es)
CA (1) CA1298219C (es)
DE (1) DE3468690D1 (es)
DK (1) DK447684A (es)
ES (1) ES8606885A1 (es)
FI (1) FI843668L (es)
GR (1) GR80403B (es)
HU (1) HU196460B (es)
IL (1) IL72985A0 (es)
MC (1) MC1623A1 (es)
NO (1) NO159610C (es)
NZ (1) NZ209590A (es)
PH (1) PH19646A (es)
PT (1) PT79230B (es)
ZA (1) ZA846549B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
US5385738A (en) * 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
JPS60172999A (ja) * 1983-12-20 1985-09-06 Suntory Ltd 新規な塩基性ポリペプチドおよびその製造法
US4758656A (en) * 1983-12-26 1988-07-19 Kyowa Hakko Kogyo Co., Ltd. Novel human interferon-gamma polypeptide derivative
DE3414831A1 (de) * 1984-04-19 1985-10-31 Hoechst Ag, 6230 Frankfurt Herstellung von polypeptiden mit human-gammainterferon-aktivitaet
US4921698A (en) * 1984-05-25 1990-05-01 Asahi Kasei Kogyo Kabushiki Kaisha Polypeptide having gamma-interferon activity lacking amino acids coded by exon 4
IL75302A0 (en) * 1984-06-06 1985-09-29 Takeda Chemical Industries Ltd Novel polypeptide and production thereof
PT84504B (pt) * 1986-03-18 1989-11-10 Research Corp Metodo para a deteccao de haptenos em tecnicas de imunoensaio
US4908432A (en) * 1987-01-09 1990-03-13 New York University Novel polypeptide having gamma-interferon activity
NO162160C (no) * 1987-01-09 1989-11-15 Medi Cult As Serumfritt vekstmedium, samt anvendelse derav.
US5165921A (en) * 1989-01-23 1992-11-24 National Geno Sciences, Inc. Method for treating condyloma acuminatum with interferon
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
WO1998052588A1 (fr) 1997-05-21 1998-11-26 Medion Research Laboratories Inc. Agents therapeutiques adaptes a des affections respiratoires
YU32402A (sh) 1999-11-12 2005-03-15 Maxygen Holdings Ltd. Konjugati gama interferona
JP2003513681A (ja) 1999-11-12 2003-04-15 マキシゲン・ホールディングス・リミテッド インターフェロンガンマ・コンジュゲート
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) * 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
AU2003239774A1 (en) * 2002-07-03 2004-01-23 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
JP4889505B2 (ja) 2004-02-02 2012-03-07 アンブレツクス・インコーポレイテツド 被修飾されたヒト成長ホルモンポリペプチドおよびこれらの使用
WO2009100255A2 (en) 2008-02-08 2009-08-13 Ambrx, Inc. Modified leptin polypeptides and their uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
EP0088540A3 (en) * 1982-02-22 1984-10-17 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human immune interferon-like polypeptides
AU571460B2 (en) * 1982-09-27 1988-04-21 Cancer Institute Of Japanese Foundation For Cancer Research Alpha interferon dna, recombinant plasmid, engineered organism and alpha interferon polypeptide
US4432895A (en) * 1982-11-24 1984-02-21 Hoffmann-La Roche Inc. Monomeric interferons
US4485017A (en) * 1982-12-22 1984-11-27 Cetus Corporation Isolation of human interferon by immunosorbent and high performance liquid chromatography
US4476049A (en) * 1983-09-20 1984-10-09 Hoffmann-La Roche Inc. Method for the extraction of immune interferon

Also Published As

Publication number Publication date
PH19646A (en) 1986-06-04
DE3468690D1 (en) 1988-02-18
PT79230A (en) 1984-10-01
PT79230B (en) 1986-11-18
NO843751L (no) 1985-03-21
EP0136620A1 (en) 1985-04-10
ES536027A0 (es) 1986-05-16
AU577314B2 (en) 1988-09-22
IL72985A0 (en) 1984-12-31
MC1623A1 (fr) 1985-09-26
EP0136620B1 (en) 1988-01-13
AU3330384A (en) 1985-03-28
CA1298219C (en) 1992-03-31
NO159610C (no) 1989-01-18
HU196460B (en) 1988-11-28
JPS6163697A (ja) 1986-04-01
DK447684A (da) 1985-03-21
ZA846549B (en) 1985-04-24
GR80403B (en) 1985-01-18
DK447684D0 (da) 1984-09-19
FI843668L (fi) 1985-03-21
US4604284A (en) 1986-08-05
NO159610B (no) 1988-10-10
HUT35288A (en) 1985-06-28
NZ209590A (en) 1989-01-27
ATE31933T1 (de) 1988-01-15
KR850002283A (ko) 1985-05-10
FI843668A0 (fi) 1984-09-19

Similar Documents

Publication Publication Date Title
ES8606885A1 (es) Un procedimiento para la produccion de un polipeptido
PT76360A (en) Expression processing and secretion of heterologus protein by yeast
ES8608541A1 (es) Un metodo para extraer interferon inmune humano recombinante intacto
PT77573B (en) Human immune interferon protein and production thereof
ZW4683A1 (en) Homogeneous human immune interferon and process therefor
ZA86338B (en) Novel growth hormone-releasing peptides and method of treating mammals therewith
IE830413L (en) Homogeneous human immune interferon