ES8606493A1 - Un procedimiento para la preparacion de una proteina hibrida fibrinoliticamente activa - Google Patents
Un procedimiento para la preparacion de una proteina hibrida fibrinoliticamente activaInfo
- Publication number
- ES8606493A1 ES8606493A1 ES538999A ES538999A ES8606493A1 ES 8606493 A1 ES8606493 A1 ES 8606493A1 ES 538999 A ES538999 A ES 538999A ES 538999 A ES538999 A ES 538999A ES 8606493 A1 ES8606493 A1 ES 8606493A1
- Authority
- ES
- Spain
- Prior art keywords
- hybrid protein
- chain
- fibronolytically
- preparation
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
METODO DE PREPARACION DE PROTEINAS HIBRIDAS FIBRINOLITICAMENTE ACTIVAS QUE COMPRENDE UNA CADENA DE PROTEASA DE DOS CADENAS UNIDAS A UNA CADENA DE PROTEASA DE DOS CADENAS DIFERENTES, O A LA MISMA CADENA DE LA MISMA PROTEASA. COMPRENDE LA MEZCLA DE UNA CADENA DE UNA PROTEASA CON UNA CADENA DE LA OTRA PROTEASA, OPCIONALMENTE CON DIALISIS, EN CONDICIONES OXIDATIVAS, DURANTE UNO O MAS DIAS; SEPARACION MEDIANTE TECNICAS CROMATOGRAFICAS DE LA PROTEINA HIBRIDA RESULTANTE, EN LA QUE, AL MENOS, UNA DE LAS CADENAS DERIVA DE UNA PROTEASA FIBRINOLITICAMENTE ACTIVA, DE FORMA QUE LA PROTEINA HIBRIDA TIENE UN SITIO CATALITICO ESENCIAL PARA LA ACTIVIDAD FIBRINOLITICA QUE ESTA BLOQUEADO. ESTAS PROTEINAS TIENEN APLICACIONES PARA EL TRATAMIENTO DE ENFERMEDADES TROMBOTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838334498A GB8334498D0 (en) | 1983-12-24 | 1983-12-24 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES538999A0 ES538999A0 (es) | 1986-04-01 |
ES8606493A1 true ES8606493A1 (es) | 1986-04-01 |
Family
ID=10553870
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538999A Expired ES8606493A1 (es) | 1983-12-24 | 1984-12-21 | Un procedimiento para la preparacion de una proteina hibrida fibrinoliticamente activa |
ES550008A Expired ES8702494A1 (es) | 1983-12-24 | 1985-12-16 | Un procedimiento para la preparacion de una proteina hibridafibrinoliticamente activa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550008A Expired ES8702494A1 (es) | 1983-12-24 | 1985-12-16 | Un procedimiento para la preparacion de una proteina hibridafibrinoliticamente activa |
Country Status (11)
Country | Link |
---|---|
US (3) | US4752581A (es) |
EP (1) | EP0155387B1 (es) |
JP (1) | JPS60252422A (es) |
AU (1) | AU580023B2 (es) |
DE (1) | DE3479632D1 (es) |
ES (2) | ES8606493A1 (es) |
GB (1) | GB8334498D0 (es) |
GR (1) | GR82557B (es) |
IE (1) | IE57946B1 (es) |
NZ (1) | NZ210697A (es) |
ZA (1) | ZA849924B (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
US4880776A (en) * | 1983-12-24 | 1989-11-14 | Beecham Group P.L.C. | Plasmin A-chain urokinase B-chain hybrid protein |
GB8609948D0 (en) * | 1986-04-23 | 1986-05-29 | Beecham Group Plc | Compounds |
US5234686A (en) * | 1985-04-03 | 1993-08-10 | Beecham Group P.L.C. | Human tissue plasminogen activator consisting essentially of t-PA residues to 160 to 527, pharmaceutical compositions and methods of treatment |
US4916071A (en) * | 1985-08-14 | 1990-04-10 | American Home Products Corporation | Poly-kringle plasminogen activator |
US5045315A (en) * | 1985-08-14 | 1991-09-03 | American Home Products Corporation | Process for treating thrombosis by administering poly-kringle plasminogen activator |
US4997766A (en) * | 1986-07-11 | 1991-03-05 | American Home Products Corporation | Poly-kringle plasminogen activator |
EP0231883B1 (en) * | 1986-01-31 | 1992-09-02 | Sagami Chemical Research Center | Hybrid plasminogen activator-like polypeptide |
US5204255A (en) * | 1986-01-31 | 1993-04-20 | Sagami Chemical Research Center | Hybrid tissue plasminogen activator/urokinase polypeptides |
US4828988A (en) * | 1986-05-15 | 1989-05-09 | Smith Kline - Rit | Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine |
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
FI100106B (fi) * | 1986-12-05 | 1997-09-30 | Novartis Ag | Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi |
US5242819A (en) * | 1986-12-05 | 1993-09-07 | Ciba-Geigy Corporation | DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase |
US5580559A (en) * | 1986-12-05 | 1996-12-03 | Ciba-Geigy Corporation | Hybrid plasminogen activator |
ZA879286B (en) * | 1986-12-16 | 1988-10-26 | Smith Kline Rit | New plasminogen activators |
WO1988005081A2 (en) * | 1986-12-30 | 1988-07-14 | Cetus Corporation | Novel plasminogen activator |
NL8700013A (nl) * | 1987-01-06 | 1988-08-01 | Leuven Res & Dev Vzw | Hybride plasminogeenactivatoren met verbeterde trombolytische eigenschappen en geneesmiddelen die deze plasminogeenactivatoren bevatten. |
GB8705377D0 (en) * | 1987-03-07 | 1987-04-08 | Beecham Group Plc | Compounds |
GB8707369D0 (en) * | 1987-03-27 | 1987-04-29 | Beecham Group Plc | Enzyme derivatives |
NL8701021A (nl) * | 1987-04-29 | 1988-11-16 | Stichting Centraal Lab | Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten. |
GB8711957D0 (en) * | 1987-05-20 | 1987-06-24 | Beecham Group Plc | Compounds |
US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
ZA884012B (en) * | 1987-06-04 | 1989-02-22 | Zymogenetics Inc | Tissue plasminogen activator analogs having modified growth factor domains |
GB8715302D0 (en) * | 1987-06-30 | 1987-08-05 | Ordidge R J | Nmr spectroscopy |
US5302390A (en) * | 1987-07-01 | 1994-04-12 | Beecham Group Plc | Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment |
PT87869B (pt) * | 1987-07-01 | 1995-03-01 | Beecham Group Plc | Processo para a preparacao de um activador de plasminogenio hibrido |
EP0394261A4 (en) * | 1987-07-06 | 1991-09-11 | Genetics Institute, Inc. | Novel thrombolytic proteins |
JP2708749B2 (ja) * | 1987-08-10 | 1998-02-04 | エーザイ株式会社 | 修飾型tPA含有注射用組成物 |
WO1990001332A1 (en) * | 1988-08-10 | 1990-02-22 | Cetus Corporation | Plasminogen activator-heparin conjugates |
US4892826A (en) * | 1988-10-11 | 1990-01-09 | Abbott Laboratories | Process for the preparation of urokinase derivatives |
US5198346A (en) * | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
AU6470590A (en) | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
US5141862A (en) * | 1990-04-17 | 1992-08-25 | Smithkline Beecham Corporation | Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr |
US5227297A (en) * | 1990-04-17 | 1993-07-13 | Smithkline Beecham Corporation | Affinity purification ligands |
GB9013345D0 (en) * | 1990-06-14 | 1990-08-08 | Beecham Group Plc | Novel compounds |
US5632986A (en) * | 1991-05-09 | 1997-05-27 | The University Of Washington | Phospholipid-targeted thrombolytic agents |
WO1993009229A1 (en) * | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
WO1993014199A1 (en) * | 1992-01-13 | 1993-07-22 | Abbott Laboratories | A pump-1 catalyzed method of making low molecular weight urokinase-type plasminogen activator |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
AU689184B2 (en) | 1993-12-07 | 1998-03-26 | Genetics Institute, Llc | BMP-12, BMP-13 and tendon-inducing compositions thereof |
GB9614871D0 (en) | 1996-07-15 | 1996-09-04 | Smithkline Beecham Plc | Compounds |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
ES2225241T3 (es) | 1999-10-15 | 2005-03-16 | Genetics Institute, Llc | Formulaciones de acido hialuronico para suministrar proteinas osteogenicas. |
US7544500B2 (en) * | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
JP2005500280A (ja) * | 2001-06-01 | 2005-01-06 | ワイエス | 骨形成タンパク質(bmp)をコードする配列の全身投与のための組成物および方法 |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
AU2003228958C1 (en) * | 2002-05-17 | 2009-01-08 | Fidia Advanced Biopolymers, S.R.L. | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
SI1675608T1 (sl) * | 2003-09-12 | 2007-08-31 | Wyeth Corp | Injektibilne trdne paličice kalcijevega fosfata za dajanje osteogenih proteinov |
WO2005059142A1 (en) * | 2003-12-18 | 2005-06-30 | Werner Seeger | Novel chimeric plasminogen activators and their pharmaceutical use |
EP2297317A4 (en) * | 2008-06-04 | 2011-12-07 | Talecris Biotherapeutics Inc | COMPOSITION, METHOD AND NECESSARY FOR THE PREPARATION OF PLASMINE |
HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082612A (en) * | 1976-09-24 | 1978-04-04 | Michael Reese Research Foundation | Plasminogen activator complex |
NZ191320A (en) * | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
AU546758B2 (en) * | 1980-03-03 | 1985-09-19 | Ryan, A.T. | Feeding granular material into a gas stream |
ZA831399B (en) * | 1982-03-05 | 1984-02-29 | Health Lab Service Board | New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them |
DE3361610D1 (en) * | 1982-04-07 | 1986-02-06 | Beecham Group Plc | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them |
WO1985002414A1 (en) * | 1983-11-29 | 1985-06-06 | Igen, Inc. | Method of catalyzing chemical reactions |
JPS60136520A (ja) * | 1983-12-23 | 1985-07-20 | Otsuka Pharmaceut Co Ltd | フイブリン吸着性ウロキナ−ゼ複合体 |
GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
GB8334499D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Derivatives |
GB8508717D0 (en) * | 1985-04-03 | 1985-05-09 | Beecham Group Plc | Composition |
US4916071A (en) * | 1985-08-14 | 1990-04-10 | American Home Products Corporation | Poly-kringle plasminogen activator |
-
1983
- 1983-12-24 GB GB838334498A patent/GB8334498D0/en active Pending
-
1984
- 1984-12-13 EP EP84115345A patent/EP0155387B1/en not_active Expired
- 1984-12-13 DE DE8484115345T patent/DE3479632D1/de not_active Expired
- 1984-12-20 ZA ZA849924A patent/ZA849924B/xx unknown
- 1984-12-21 IE IE3332/84A patent/IE57946B1/en not_active IP Right Cessation
- 1984-12-21 AU AU37071/84A patent/AU580023B2/en not_active Ceased
- 1984-12-21 ES ES538999A patent/ES8606493A1/es not_active Expired
- 1984-12-21 US US06/684,593 patent/US4752581A/en not_active Expired - Fee Related
- 1984-12-21 NZ NZ210697A patent/NZ210697A/xx unknown
- 1984-12-21 GR GR82557A patent/GR82557B/el unknown
- 1984-12-24 JP JP59272694A patent/JPS60252422A/ja active Pending
-
1985
- 1985-12-16 ES ES550008A patent/ES8702494A1/es not_active Expired
-
1988
- 1988-02-22 US US07/158,581 patent/US4908204A/en not_active Expired - Fee Related
- 1988-02-22 US US07/158,542 patent/US4992274A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3479632D1 (en) | 1989-10-12 |
EP0155387A3 (en) | 1986-12-30 |
ES538999A0 (es) | 1986-04-01 |
ES550008A0 (es) | 1987-01-01 |
AU580023B2 (en) | 1988-12-22 |
IE843332L (en) | 1985-06-24 |
GB8334498D0 (en) | 1984-02-01 |
ZA849924B (en) | 1986-04-30 |
NZ210697A (en) | 1989-06-28 |
ES8702494A1 (es) | 1987-01-01 |
AU3707184A (en) | 1985-07-04 |
IE57946B1 (en) | 1993-05-19 |
GR82557B (en) | 1985-04-23 |
US4752581A (en) | 1988-06-21 |
US4908204A (en) | 1990-03-13 |
EP0155387A2 (en) | 1985-09-25 |
US4992274A (en) | 1991-02-12 |
JPS60252422A (ja) | 1985-12-13 |
EP0155387B1 (en) | 1989-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970612 |