ES8606390A1 - Un procedimiento para preparar nuevos peptidos atriales. - Google Patents

Un procedimiento para preparar nuevos peptidos atriales.

Info

Publication number
ES8606390A1
ES8606390A1 ES537520A ES537520A ES8606390A1 ES 8606390 A1 ES8606390 A1 ES 8606390A1 ES 537520 A ES537520 A ES 537520A ES 537520 A ES537520 A ES 537520A ES 8606390 A1 ES8606390 A1 ES 8606390A1
Authority
ES
Spain
Prior art keywords
ser
gly
arg
phe
atrial peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537520A
Other languages
English (en)
Other versions
ES537520A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of ES537520A0 publication Critical patent/ES537520A0/es
Publication of ES8606390A1 publication Critical patent/ES8606390A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PEPTIDOS ATRIALES QUE TIENEN UNA ACTIVIDAD NATRIURETICA POTENTE Y QUE COMPRENDEN LA SECUENCIA DE AMINOACIDOS DE FORMULA GENERAL (1), Y SUS SALES, ESTERES O AMIDAS FISIOLOGICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UN HOMOGENEIZADO BRUTO DE TEJIDO ATRIAL DE MAMIFERO Y SE HIERVE EL MATERIAL QUE SOBRENADA; SEGUNDA, SE DESALIFICA EL MATERIAL QUE SOBRENADA POR CROMATOGRAFIA DE FILTRACION EN GEL SOBRE RESINA DE DEXTRANO RETICULADO; TERCERA, SE CROMATOGRAFIA POR FILTRACION EN GEL LA FRACCION DE PROTEINAS SOBRE RESINA DE DEXTRANO RETICULADO; CUARTA, SE CROMATOGRAFIA POR CAMBIO DE IONES LA FRACCION DE PROTEINAS DE BAJO PESO MOLECULAR; QUINTA, SE CROMATOGRAFIA POR CROMATOGRAFIA DE LIQUIDOS DE ALTO RENDIMIENTO LAS DOS FRACCIONES PRINCIPALES DE PROTEINA; Y POR ULTIMO, SE RECUPERAN LAS FRACCIONES DE PEPTIDO ATRIAL SEPARADAS.
ES537520A 1983-11-10 1984-11-08 Un procedimiento para preparar nuevos peptidos atriales. Expired ES8606390A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55137283A 1983-11-10 1983-11-10
US06/569,684 US4496544A (en) 1983-11-10 1984-01-10 Atrial Peptides

Publications (2)

Publication Number Publication Date
ES537520A0 ES537520A0 (es) 1986-04-01
ES8606390A1 true ES8606390A1 (es) 1986-04-01

Family

ID=27069747

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537520A Expired ES8606390A1 (es) 1983-11-10 1984-11-08 Un procedimiento para preparar nuevos peptidos atriales.

Country Status (12)

Country Link
US (1) US4496544A (es)
EP (1) EP0142487B1 (es)
JP (1) JPH0672156B2 (es)
AU (1) AU566235B2 (es)
DE (1) DE3480930D1 (es)
DK (1) DK533484A (es)
ES (1) ES8606390A1 (es)
FI (1) FI83661C (es)
GR (1) GR80905B (es)
IE (1) IE58819B1 (es)
IL (1) IL73466A (es)
NO (1) NO844489L (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0116784B1 (en) * 1982-02-22 1992-06-10 Queen's University At Kingston Atrial natriuretic factor
AU572173B2 (en) * 1983-08-29 1988-05-05 Institut De Recherches Cliniques De Montreal Natriuretic factors
JPS60136596A (ja) * 1983-12-26 1985-07-20 Suntory Ltd ペプチド及びこれを有効成分とする利尿剤
US4952561A (en) * 1984-02-07 1990-08-28 Merck & Co., Inc. Cardiac atrial peptides
JPH0794473B2 (ja) * 1984-03-02 1995-10-11 サントリー株式会社 新規なペプチド及びこれを有効成分とする利尿剤
US5212286A (en) * 1984-04-19 1993-05-18 Scios Nova Inc. Atrial natriuretic/vasodilator peptide compounds
US4618600A (en) * 1984-04-19 1986-10-21 Biotechnology Research Associates, J.V. Novel polypeptide diuretic/vasodilators
JPH0780907B2 (ja) * 1984-04-19 1995-08-30 シオス・ノバ・インク 新規な心房性ナトリウム尿排泄亢進性及び血管拡張性ポリペプチド
WO1985004872A1 (en) * 1984-04-24 1985-11-07 The Salk Institute For Biological Studies Atrial peptide analogs
JPH0672157B2 (ja) * 1984-08-29 1994-09-14 味の素株式会社 新規ペプチド
US4652549A (en) * 1985-01-22 1987-03-24 Merck & Co., Inc. Cardiac anti-hypertrophic agents
US5087564A (en) * 1985-06-20 1992-02-11 Monsanto Company Release of recombinant peptides from polypeptides using V8 endopeptidase
WO1987002674A1 (en) * 1985-11-05 1987-05-07 Biotechnology Research Associates, J.V. Analogs of atrial natriuretic peptides
JP3042782B2 (ja) * 1985-11-05 2000-05-22 サイオス インコーポレイテッド 心房性ナトリウム尿排泄亢進ペプチド類似化合物
US4757048A (en) * 1985-11-05 1988-07-12 Biotechnology Research Associates J.V. Synthetic analogs of atrial natriuretic peptides
DE3614833A1 (de) * 1986-01-16 1987-07-23 Hoechst Ag Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US4716147A (en) * 1986-03-27 1987-12-29 Monsanto Company Synthetic airial peptides
US4721704A (en) * 1986-05-09 1988-01-26 Peninsula Laboratories, Inc. Potent synthetic atrial peptide analogs
EP0246795A3 (en) * 1986-05-20 1990-04-04 Advanced Peptide Development Limited Synthetic natriuretic peptides
US4740499A (en) * 1986-07-28 1988-04-26 Monsanto Company Method of enhancing the bioactivity of atrial peptides
DE3723551A1 (de) * 1987-07-16 1989-01-26 Hoechst Ag Peptide mit vasorelaxierender, natriuretischer und diuretischer wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
US4804650A (en) * 1986-10-28 1989-02-14 Biotechnology Research Associates, J.V. Analogs of atrial natriuretic peptides
US5500230A (en) * 1987-01-23 1996-03-19 The General Hospital Corporation Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators
JP2845913B2 (ja) * 1987-01-23 1999-01-13 ザ・ゼネラル・ホスピタル・コーポレイション 緑内障、水頭症、および脳水腫（頭蓋液量異常）治療用のアトリオペプチン、グアニル酸シクラーゼ賦活物質、およびホスホジエステラーゼ阻害物質
IT1216865B (it) 1987-02-03 1990-03-14 Eniricerche Spa Derivato argininico, procedimento per la sua preparazione e suo impiego nelle sintesi peptidiche.
EP0310887B1 (en) * 1987-10-09 1993-06-02 Takeda Chemical Industries, Ltd. Vasoconstrictor peptide
US4935492A (en) * 1987-12-24 1990-06-19 California Biotechnology Inc. Cyclic analogs of atrial natriuretic peptides
US5047397A (en) * 1988-08-26 1991-09-10 California Biotechnology Inc. Linear analogs of atrial natriuretic peptides
CA1339210C (en) * 1988-05-31 1997-08-05 John Lewicki Recombinant techniques for production of novel natriuretic and vasodilator peptides
US5114923A (en) * 1988-05-31 1992-05-19 California Biotechnology Inc. Recombinant techniques for production of novel natriuretic and vasodilator peptides
JP2801079B2 (ja) * 1990-11-14 1998-09-21 サントリー株式会社 Ａｎｐ関連新規ペプチド
JP2809533B2 (ja) * 1991-01-31 1998-10-08 壽之 松尾 Ｃｎｐ類似体ペプチド
US5846932A (en) * 1993-11-12 1998-12-08 Genentech, Inc. Receptor specific atrial natriuretic peptides
US6525022B1 (en) 1993-11-12 2003-02-25 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5665704A (en) * 1993-11-12 1997-09-09 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5486519A (en) * 1994-08-22 1996-01-23 Greenwald; James E. Method for treatment of acute renal failure
US5521191A (en) * 1994-10-17 1996-05-28 Washington University Method for treatment of arterial stenosis
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
ES2354881T3 (es) 2003-06-20 2011-03-18 Mayo Foundation For Medical Education And Research Isoformas de péptido natriurético cerebral.
EP2004633A4 (en) * 2006-03-30 2009-08-26 Palatin Technologies Inc LINEAR CONSTRUCTIONS OF NATRIURETIC PEPTIDES
BRPI0709427A2 (pt) * 2006-03-30 2011-07-12 Palatin Technologies Inc "construto cìclico, composição farmacêutica e uso de um composto
US8580746B2 (en) 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
CA2660294C (en) * 2006-08-08 2017-08-29 Mayo Foundation For Medical Education And Research Diuretic and natriuretic polypeptides
WO2009036448A2 (en) * 2007-09-15 2009-03-19 Mayo Foundation For Medical Education And Research Natriuretic peptide receptor-c agonists
CN107090028A (zh) 2011-08-30 2017-08-25 梅约医学教育与研究基金会 利钠多肽
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846084B (en) * 1983-08-29 1985-05-29 Montreal Inst Rech Cliniques Natriuretic factors

Also Published As

Publication number Publication date
EP0142487B1 (en) 1990-01-03
FI844424L (fi) 1985-05-11
NO844489L (no) 1985-05-13
FI83661C (fi) 1991-08-12
EP0142487A2 (en) 1985-05-22
FI844424A0 (fi) 1984-11-09
IE842881L (en) 1985-05-10
ES537520A0 (es) 1986-04-01
IL73466A (en) 1989-03-31
JPS60214797A (ja) 1985-10-28
GR80905B (en) 1985-04-02
DK533484A (da) 1985-05-11
AU3525284A (en) 1985-05-16
DE3480930D1 (de) 1990-02-08
JPH0672156B2 (ja) 1994-09-14
AU566235B2 (en) 1987-10-15
IL73466A0 (en) 1985-02-28
DK533484D0 (da) 1984-11-09
EP0142487A3 (en) 1986-04-30
FI83661B (fi) 1991-04-30
US4496544A (en) 1985-01-29
IE58819B1 (en) 1993-11-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001102