ES8606354A1 - 6-sustituido-5-feniltetrazol 1,5-a-1,2,4 triazol 1,5-c piri-midinas - Google Patents

6-sustituido-5-feniltetrazol 1,5-a-1,2,4 triazol 1,5-c piri-midinas

Info

Publication number
ES8606354A1
ES8606354A1 ES540065A ES540065A ES8606354A1 ES 8606354 A1 ES8606354 A1 ES 8606354A1 ES 540065 A ES540065 A ES 540065A ES 540065 A ES540065 A ES 540065A ES 8606354 A1 ES8606354 A1 ES 8606354A1
Authority
ES
Spain
Prior art keywords
phenyltetrazolo
pyrimidines
substituted
triazolo
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540065A
Other languages
English (en)
Other versions
ES540065A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES540065A0 publication Critical patent/ES540065A0/es
Publication of ES8606354A1 publication Critical patent/ES8606354A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 6-SUSTITUIDO-5-FENILTETRAZOL(1,5-A) - (1,2,4)TRIAZOL-(1,5-C)PIRIMIDINAS. COMPRENDE: A) HALOGENAR A (A) D.F (II) CON ACIDO CLORHIDRICO, EN NITRITO SODICO, PARA DAR A (B) D.F (III) Y; B) TRATAR A (III) CON AZIDA SODICA EN DIMETILFORMAMIDA, PARA OBTENER A (C) D.F (I) Y SUS ACIDO-TAUTOMEROS. SIENDO: (A) AK-7-FENIL-BK-(2,3-C) PIRIMIDIN-5-AMINA; (B) 5-CLORO O 5-BROMO-(AK) FENIL (BK)-(CK); (C) 6-SUSTITUIDO-5-FENILTETRAZOL (1,5-A)-BK-CK; (AK) 8-(2-ALCOXI-ALQUIL)-; (BK) -(1,2,4)TRIAZOL-; (CK) -(1,5-C) PIRIMIDINAS; R ALQUILO DE C 1 A 8 X HALO, ALCOXI DE C 1 A 4 O ALQUILO DE C 1 A 4; Y CL O BR; N 1,2,3,4,5 O 6; M 0,1,2,3,4 O 5 Y D.F DE FORMULA. SE UTILIZAN COMO VASODILATADORES RENALES, DIURETICOS O AGENTES HIPERTENSIVOS.
ES540065A 1984-02-03 1985-02-01 6-sustituido-5-feniltetrazol 1,5-a-1,2,4 triazol 1,5-c piri-midinas Expired ES8606354A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/576,700 US4562192A (en) 1984-02-03 1984-02-03 6-Substituted-5-phenyltetrazolo[1,5-a][1,2,4]triazole[1,5-c]pyrimidines, and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ES540065A0 ES540065A0 (es) 1986-04-01
ES8606354A1 true ES8606354A1 (es) 1986-04-01

Family

ID=24305604

Family Applications (4)

Application Number Title Priority Date Filing Date
ES540065A Expired ES8606354A1 (es) 1984-02-03 1985-02-01 6-sustituido-5-feniltetrazol 1,5-a-1,2,4 triazol 1,5-c piri-midinas
ES549983A Expired ES8702411A1 (es) 1984-02-03 1985-12-16 Procedimiento para preparar 6-sustituido-5-feniltetrazol (1,5-a)-(1,2,4)triazol-(1,5-c)pirimidinas
ES549984A Expired ES8702412A1 (es) 1984-02-03 1985-12-16 Procedimiento para preparar 6-sustituido-5-feniltetrazol (1,5-a)-(1,2,4)triazol-(1,5-c)pirimidinas
ES549982A Expired ES8702410A1 (es) 1984-02-03 1985-12-16 Procedimiento para preparar 6-sustituido-5-feniltetrazol (1,5-a)-(1,2,4)triazol-(1,5-c)pirimidinas

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES549983A Expired ES8702411A1 (es) 1984-02-03 1985-12-16 Procedimiento para preparar 6-sustituido-5-feniltetrazol (1,5-a)-(1,2,4)triazol-(1,5-c)pirimidinas
ES549984A Expired ES8702412A1 (es) 1984-02-03 1985-12-16 Procedimiento para preparar 6-sustituido-5-feniltetrazol (1,5-a)-(1,2,4)triazol-(1,5-c)pirimidinas
ES549982A Expired ES8702410A1 (es) 1984-02-03 1985-12-16 Procedimiento para preparar 6-sustituido-5-feniltetrazol (1,5-a)-(1,2,4)triazol-(1,5-c)pirimidinas

Country Status (16)

Country Link
US (1) US4562192A (es)
EP (1) EP0152841B1 (es)
JP (1) JPS60237087A (es)
AT (1) ATE35990T1 (es)
AU (1) AU571923B2 (es)
CA (1) CA1218061A (es)
DE (1) DE3563965D1 (es)
DK (1) DK44385A (es)
ES (4) ES8606354A1 (es)
FI (1) FI80699C (es)
GR (1) GR850297B (es)
IL (1) IL74215A (es)
NZ (1) NZ211025A (es)
PH (1) PH23945A (es)
PT (1) PT79909B (es)
ZA (1) ZA85802B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071643A (en) * 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
FR2678618B1 (fr) * 1991-07-05 1993-11-05 Upsa Laboratoires Nouveaux derives de triazolo pyrimidine antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5358950A (en) * 1991-07-05 1994-10-25 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US4405780A (en) * 1979-08-08 1983-09-20 G. D. Searle & Co. 8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides
US4483987A (en) * 1983-06-20 1984-11-20 G. D. Searle & Co. 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides

Also Published As

Publication number Publication date
PT79909B (en) 1986-11-10
CA1218061A (en) 1987-02-17
PT79909A (en) 1985-03-01
ES540065A0 (es) 1986-04-01
ES549983A0 (es) 1986-12-16
FI850443A0 (fi) 1985-02-01
ZA85802B (en) 1986-03-26
NZ211025A (en) 1988-09-29
ATE35990T1 (de) 1988-08-15
DK44385A (da) 1985-08-04
IL74215A (en) 1988-09-30
ES8702411A1 (es) 1986-12-16
ES8702412A1 (es) 1987-01-01
DE3563965D1 (de) 1988-09-01
ES8702410A1 (es) 1987-01-01
JPS60237087A (ja) 1985-11-25
US4562192A (en) 1985-12-31
AU3826085A (en) 1985-08-08
FI80699B (fi) 1990-03-30
DK44385D0 (da) 1985-01-31
FI80699C (fi) 1990-07-10
ES549982A0 (es) 1987-01-01
FI850443L (fi) 1985-08-04
IL74215A0 (en) 1985-05-31
GR850297B (es) 1985-05-29
PH23945A (en) 1990-01-23
EP0152841B1 (en) 1988-07-27
EP0152841A1 (en) 1985-08-28
ES549984A0 (es) 1987-01-01
AU571923B2 (en) 1988-04-28

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