ES8605681A1 - Procedimiento para la obtencion de glicoproteinas antitumo- rales modificadas en sus motivos glucidicos - Google Patents
Procedimiento para la obtencion de glicoproteinas antitumo- rales modificadas en sus motivos glucidicosInfo
- Publication number
- ES8605681A1 ES8605681A1 ES544337A ES544337A ES8605681A1 ES 8605681 A1 ES8605681 A1 ES 8605681A1 ES 544337 A ES544337 A ES 544337A ES 544337 A ES544337 A ES 544337A ES 8605681 A1 ES8605681 A1 ES 8605681A1
- Authority
- ES
- Spain
- Prior art keywords
- glycoprotein
- antitumour
- obtaining
- modified
- carbohydrate moieties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
- A61K47/6827—Ricin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE GLICOPROTEINAS ANTITUMORALES, MODIFICADAS EN SUS MOTIVOS GLUCIDICOS. CONSISTE EN TRATAR UNA SOLUCION ACUOSA DE UNA CICLOPROTEINA INACTIVADORA DE LOS RIBOSOMAS, CUYOS GRUPOS TIOLICOS ESTAN EVENTUALMENTE PROTEGIDOS, CON UNA SOLUCION ACUOSA DE UN PERYODATO ALCALINO, DURANTE UN PERIODO DE TIEMPO COMPRENDIDO ENTRE 0,2 Y 24 HORAS, A UNA TEMPERATURA ENTRE 0 Y 15 GRADOS Y AL RESGUARDO DE LA LUZ, A CONTINUACION SE DESBLOQUEA EVENTUALMENTE EL GRUPO TIOLICO Y SE AISLA EL PRODUCTO FINAL. EN CALIDAD DE GLICOPROTEINA DE PARTIDA SE UTILIZA LA CADENA A DE LA RICINA, LA GELONINA, LA GPIR MOM O LA GPIR DIANTINA 30. DE APLICACION EN MEDICINA Y FARMACIA POR SUS PROPIEDADES FARMACOCINETICAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8409703A FR2566271B1 (fr) | 1984-06-20 | 1984-06-20 | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
FR8502067A FR2577137B1 (fr) | 1985-02-13 | 1985-02-13 | Glycoproteines antitumorales, modifiees sur leurs motifs glucidiques |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8605681A1 true ES8605681A1 (es) | 1986-04-01 |
ES544337A0 ES544337A0 (es) | 1986-04-01 |
Family
ID=26224020
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544337A Expired ES8605681A1 (es) | 1984-06-20 | 1985-06-19 | Procedimiento para la obtencion de glicoproteinas antitumo- rales modificadas en sus motivos glucidicos |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0172045B1 (es) |
JP (1) | JPS6112628A (es) |
KR (1) | KR930000058B1 (es) |
AT (1) | ATE40700T1 (es) |
AU (1) | AU593211B2 (es) |
CA (1) | CA1248874A (es) |
DE (1) | DE3568167D1 (es) |
DK (1) | DK166626B1 (es) |
ES (1) | ES8605681A1 (es) |
GR (1) | GR851497B (es) |
IE (1) | IE58514B1 (es) |
IL (1) | IL75484A0 (es) |
NZ (1) | NZ212439A (es) |
PT (1) | PT80662B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2577135B1 (fr) * | 1985-02-13 | 1989-12-15 | Sanofi Sa | Immunotoxines a longue duree d'action comportant un constituant glycopeptidique inactivant les ribosomes modifie sur ses motifs polysaccharidiques |
FR2602682B1 (fr) * | 1986-08-12 | 1988-12-02 | Sanofi Sa | Immunotoxines a longue duree d'action in vivo comportant une glycoproteine inhibant les ribosomes, modifiee par oxydation des motifs osidiques et formation d'une base de schiff |
IL80973A (en) * | 1985-12-20 | 1992-08-18 | Sanofi Sa | Modified ribosome-inactivating glycoproteins,their preparation,immunotoxins containing them and pharmaceutical compositions containing such immunotoxins |
FR2601679B1 (fr) * | 1986-07-15 | 1990-05-25 | Sanofi Sa | Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant |
DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
US6610299B1 (en) | 1989-10-19 | 2003-08-26 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US6475486B1 (en) | 1990-10-18 | 2002-11-05 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US7241595B2 (en) | 1989-10-20 | 2007-07-10 | Sanofi-Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US5250532A (en) * | 1991-04-11 | 1993-10-05 | Dowelanco | 3,4,N-trisubstituted-4,5-dihydro-1H-pyrazole-1-carboxamides and their use as insecticides |
GB9808485D0 (en) * | 1998-04-21 | 1998-06-17 | Univ Cambridge Tech | Improvements relating to immunotherapy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
JPS5843926A (ja) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | 選択性制癌剤 |
-
1985
- 1985-06-09 PT PT80662A patent/PT80662B/pt not_active IP Right Cessation
- 1985-06-11 IL IL75484A patent/IL75484A0/xx not_active IP Right Cessation
- 1985-06-13 AU AU43646/85A patent/AU593211B2/en not_active Ceased
- 1985-06-13 CA CA000483940A patent/CA1248874A/en not_active Expired
- 1985-06-17 NZ NZ212439A patent/NZ212439A/xx unknown
- 1985-06-18 AT AT85401201T patent/ATE40700T1/de not_active IP Right Cessation
- 1985-06-18 DE DE8585401201T patent/DE3568167D1/de not_active Expired
- 1985-06-18 EP EP85401201A patent/EP0172045B1/fr not_active Expired
- 1985-06-18 IE IE151185A patent/IE58514B1/en not_active IP Right Cessation
- 1985-06-19 ES ES544337A patent/ES8605681A1/es not_active Expired
- 1985-06-19 GR GR851497A patent/GR851497B/el unknown
- 1985-06-19 DK DK277985A patent/DK166626B1/da not_active IP Right Cessation
- 1985-06-19 KR KR1019850004354A patent/KR930000058B1/ko not_active IP Right Cessation
- 1985-06-20 JP JP60135217A patent/JPS6112628A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
DK166626B1 (da) | 1993-06-21 |
KR930000058B1 (ko) | 1993-01-06 |
KR860000315A (ko) | 1986-01-28 |
DE3568167D1 (en) | 1989-03-16 |
JPH0582400B2 (es) | 1993-11-18 |
ES544337A0 (es) | 1986-04-01 |
DK277985A (da) | 1985-12-21 |
IL75484A0 (en) | 1985-10-31 |
PT80662A (en) | 1985-07-01 |
GR851497B (es) | 1985-11-25 |
IE58514B1 (en) | 1993-10-06 |
DK277985D0 (da) | 1985-06-19 |
PT80662B (en) | 1986-12-09 |
ATE40700T1 (de) | 1989-02-15 |
EP0172045B1 (fr) | 1989-02-08 |
AU593211B2 (en) | 1990-02-08 |
IE851511L (en) | 1985-12-20 |
EP0172045A1 (fr) | 1986-02-19 |
JPS6112628A (ja) | 1986-01-21 |
CA1248874A (en) | 1989-01-17 |
NZ212439A (en) | 1989-01-27 |
AU4364685A (en) | 1986-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970612 |