ES8604511A1 - Un procedimiento para la preparacion de derivados de -lactama - Google Patents
Un procedimiento para la preparacion de derivados de -lactamaInfo
- Publication number
- ES8604511A1 ES8604511A1 ES527711A ES527711A ES8604511A1 ES 8604511 A1 ES8604511 A1 ES 8604511A1 ES 527711 A ES527711 A ES 527711A ES 527711 A ES527711 A ES 527711A ES 8604511 A1 ES8604511 A1 ES 8604511A1
- Authority
- ES
- Spain
- Prior art keywords
- substd
- heterocyclyl
- aryl
- opt
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
- C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE B-LACTAMA. CONSISTE EN SOMETER A REACCION DE FORMILACION UN COMPUESTO DE FORMULA (II) A UNA TEMPERATURA COMPRENDIDA ENTRE C50JC Y 30JC EN UN DISOLVENTE APROTICO EN PRESENCIA DE UNA BASE TERCIARIA, PARA OBTENER DERIVADOS DE B-LACTAMA DE FORMULA (I) DONDE R1 ES FENILO, FENILO SUSTITUIDO O UN ANILLO HETEROCICLICO DE 5 O 6 MIEMBROS QUE CONTIENE HASTA TRES HETEROATOMOS SELECCIONADOS ENTRE OXIGENO, AZUFRE O NITROGENO, OPCIONALMENTE SUSTITUIDO CON HIDROXI, AMINO, HALOGENO O ALCOXI C 1 A 6; X REPRESENTA UN COMPUESTO DE FORMULA (III); E Y ES UN COMPUESTO DE FORMULA (IV). TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8209426 | 1982-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES527711A0 ES527711A0 (es) | 1986-02-01 |
ES8604511A1 true ES8604511A1 (es) | 1986-02-01 |
Family
ID=10529420
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521192A Expired ES8405411A1 (es) | 1982-03-31 | 1983-03-30 | Un procedimiento para la preparacion de derivados de b-lactama. |
ES527711A Expired ES8604511A1 (es) | 1982-03-31 | 1983-12-01 | Un procedimiento para la preparacion de derivados de -lactama |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521192A Expired ES8405411A1 (es) | 1982-03-31 | 1983-03-30 | Un procedimiento para la preparacion de derivados de b-lactama. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4537886A (es) |
EP (1) | EP0090656A1 (es) |
JP (1) | JPS58183692A (es) |
AU (1) | AU1294383A (es) |
ES (2) | ES8405411A1 (es) |
NZ (1) | NZ203734A (es) |
ZA (1) | ZA832226B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8409986D0 (en) * | 1984-04-17 | 1984-05-31 | Beecham Group Plc | Beta-lactam antibacterial agents |
DE3508258A1 (de) * | 1985-03-08 | 1986-09-18 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zur herstellung und ihre verwendung als und in arzneimitteln |
DE3509618A1 (de) * | 1985-03-16 | 1986-09-18 | Bayer Ag, 5090 Leverkusen | Ss-lactam-antibiotika, verfahren zur herstellung und ihre verwendung als arzneimittel |
US4870168A (en) * | 1987-02-26 | 1989-09-26 | Bristol-Myers Company | 3-Unsaturated alkyl cephems from 3-triflyl cephems |
DE3803169A1 (de) * | 1988-02-03 | 1989-08-17 | Bayer Ag | Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln |
US5128336A (en) * | 1988-03-23 | 1992-07-07 | Eli Lilly And Company | 3-(substituted)-1-carba(dethia)-3-cephems |
US20050245498A1 (en) * | 2002-05-14 | 2005-11-03 | Shoichet Brian K | Sterically-awkward beta-lactamase inhibitors |
US20080146535A1 (en) * | 2003-04-30 | 2008-06-19 | Tomasz Glinka | Compositions comprising carbacephem beta-lactam antibiotics and beta-lactamase inhibitors |
EA201070504A1 (ru) * | 2007-10-25 | 2010-12-30 | Эйкеоджен, Инк. | КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ |
WO2010030810A1 (en) * | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
JP7184646B2 (ja) | 2015-12-15 | 2022-12-06 | メルク・シャープ・アンド・ドーム・エルエルシー | ビアリールモノバクタム化合物および細菌感染治療のためのそれの使用方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH10309A (en) * | 1973-10-19 | 1976-11-17 | Yamanouchi Pharma Co Ltd | Penicillin derivatives |
JPS5195090A (en) * | 1975-02-14 | 1976-08-20 | 66 * dd22 * 33 hidorokishipiridajin 44 karubokishiamido * 22 * paraahidorokishifueniru * asetoamido * penishiransanno seiho | |
DE2720579A1 (de) * | 1977-05-07 | 1978-11-09 | Bayer Ag | Beta-lactam-verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2810083A1 (de) * | 1978-03-08 | 1979-09-20 | Bayer Ag | Beta-lactam-verbindungen |
JPS5616489A (en) * | 1979-07-20 | 1981-02-17 | Ajinomoto Co Inc | Imidazolecarboxylic acid derivative |
-
1983
- 1983-03-29 US US06/479,953 patent/US4537886A/en not_active Expired - Fee Related
- 1983-03-29 NZ NZ203734A patent/NZ203734A/en unknown
- 1983-03-29 AU AU12943/83A patent/AU1294383A/en not_active Abandoned
- 1983-03-29 ZA ZA832226A patent/ZA832226B/xx unknown
- 1983-03-30 JP JP58054989A patent/JPS58183692A/ja active Pending
- 1983-03-30 ES ES521192A patent/ES8405411A1/es not_active Expired
- 1983-03-30 EP EP83301786A patent/EP0090656A1/en not_active Ceased
- 1983-12-01 ES ES527711A patent/ES8604511A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NZ203734A (en) | 1986-03-14 |
US4537886A (en) | 1985-08-27 |
EP0090656A1 (en) | 1983-10-05 |
ES527711A0 (es) | 1986-02-01 |
ES521192A0 (es) | 1984-06-01 |
JPS58183692A (ja) | 1983-10-26 |
ZA832226B (en) | 1984-02-29 |
AU1294383A (en) | 1983-10-06 |
ES8405411A1 (es) | 1984-06-01 |
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