ES8602838A1 - Un procedimiento para la preparacion del derivado de 11-aza-10-desoxo-10-dihidroeritromicina a - Google Patents
Un procedimiento para la preparacion del derivado de 11-aza-10-desoxo-10-dihidroeritromicina aInfo
- Publication number
- ES8602838A1 ES8602838A1 ES527250A ES527250A ES8602838A1 ES 8602838 A1 ES8602838 A1 ES 8602838A1 ES 527250 A ES527250 A ES 527250A ES 527250 A ES527250 A ES 527250A ES 8602838 A1 ES8602838 A1 ES 8602838A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- give
- compound
- new
- aza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE N-METIL-11-AZA-10-DESOXO-10-DIHIDROERITROMICINA. COMPRENDE: A) OXIDAR UN COMPUESTO DE FORMULA (II) CON PEROXIDO DE HIDROGENO EN UN DISOLVENTE INERTE Y SOLUBLE EN AGUA; B) ALQUILAR EL PRODUCTO RESULTANTE EN (A) CON YODURO DE METILO EN UN DISOLVENTE INERTE EN LA REACCION, COMO CLOROFORMO, CLORURO DE METILENO, Y TOLUENO, EN PRESENCIA DE UN ACEPTOR DE ACIDOS, COMO HIDROXIDOS Y CARBONATOS DE METALES ALCALINOS Y AMINAS ORGANICAS; Y C) REDUCIR EL PRODUCTO DE (B) CON HIDROGENO A PRESIONES DE 1 A 70 ATMOSFERAS, EN UN DISOLVENTE INERTE A LA REACCION, COMO ALCOHOLES DE C 1 A 4, ACETATO DE ETILO Y ETERES, EN PRESENCIA DE UN CATALIZADOR CONSISTENTE EN UN METAL NOBLE COMO PD SOBRE CARBON, RH SOBRE CARBON, PT O2 Y NIQUEL RANEY, PARA OBTENER UN COMPUESTO DE FORMULA (I). SE UTILIZA COMO ANTIBIOTICOS CONTRA BACTERIAS GRAM-POSITIVAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/441,981 US4474768A (en) | 1982-07-19 | 1982-11-15 | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8602838A1 true ES8602838A1 (es) | 1985-12-01 |
| ES527250A0 ES527250A0 (es) | 1985-12-01 |
Family
ID=23755074
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES527250A Granted ES527250A0 (es) | 1982-11-15 | 1983-11-14 | Un procedimiento para la preparacion del derivado de 11-aza-10-desoxo-10-dihidroeritromicina a |
| ES544877A Expired ES8604250A1 (es) | 1982-11-15 | 1985-07-04 | Un procedimiento para la preparacion del derivado n-metiladode una 11-aza-10-desoxo-10-dihidroeritromicina a |
| ES544878A Expired ES8604251A1 (es) | 1982-11-15 | 1985-07-04 | Un procedimiento para la preparacion de n-metil-11-aza-10- desoxo-10-dihidroeritromicina a |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544877A Expired ES8604250A1 (es) | 1982-11-15 | 1985-07-04 | Un procedimiento para la preparacion del derivado n-metiladode una 11-aza-10-desoxo-10-dihidroeritromicina a |
| ES544878A Expired ES8604251A1 (es) | 1982-11-15 | 1985-07-04 | Un procedimiento para la preparacion de n-metil-11-aza-10- desoxo-10-dihidroeritromicina a |
Country Status (9)
| Country | Link |
|---|---|
| KR (1) | KR850000963B1 (es) |
| CS (1) | CS241533B2 (es) |
| DD (1) | DD215787A5 (es) |
| EG (1) | EG16882A (es) |
| ES (3) | ES527250A0 (es) |
| GR (1) | GR77556B (es) |
| PL (1) | PL141924B1 (es) |
| SU (1) | SU1274626A3 (es) |
| YU (2) | YU42885B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110655544A (zh) * | 2018-06-28 | 2020-01-07 | 洛阳惠中兽药有限公司 | 一种加米霉素有关物质的分离、制备及纯化方法 |
-
1983
- 1983-07-26 GR GR72035A patent/GR77556B/el unknown
- 1983-08-03 CS CS835758A patent/CS241533B2/cs unknown
- 1983-08-19 PL PL1983243473A patent/PL141924B1/pl unknown
- 1983-08-19 DD DD83254089A patent/DD215787A5/de not_active IP Right Cessation
- 1983-08-20 KR KR1019830003895A patent/KR850000963B1/ko not_active IP Right Cessation
- 1983-08-22 SU SU833635803A patent/SU1274626A3/ru active
- 1983-10-14 YU YU2075/83A patent/YU42885B/xx unknown
- 1983-11-14 ES ES527250A patent/ES527250A0/es active Granted
- 1983-11-15 EG EG716/83A patent/EG16882A/xx active
-
1985
- 1985-07-04 ES ES544877A patent/ES8604250A1/es not_active Expired
- 1985-07-04 ES ES544878A patent/ES8604251A1/es not_active Expired
- 1985-08-21 YU YU1332/85A patent/YU44519B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110655544A (zh) * | 2018-06-28 | 2020-01-07 | 洛阳惠中兽药有限公司 | 一种加米霉素有关物质的分离、制备及纯化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES544877A0 (es) | 1986-01-16 |
| YU133285A (en) | 1986-02-28 |
| CS241533B2 (en) | 1986-03-13 |
| SU1274626A3 (ru) | 1986-11-30 |
| YU42885B (en) | 1988-12-31 |
| KR850000963B1 (ko) | 1985-07-02 |
| PL141924B1 (en) | 1987-09-30 |
| ES544878A0 (es) | 1986-01-16 |
| ES8604250A1 (es) | 1986-01-16 |
| EG16882A (en) | 1989-06-30 |
| ES527250A0 (es) | 1985-12-01 |
| GR77556B (es) | 1984-09-24 |
| YU207583A (en) | 1985-12-31 |
| KR840006671A (ko) | 1984-12-01 |
| PL243473A1 (en) | 1984-07-30 |
| DD215787A5 (de) | 1984-11-21 |
| ES8604251A1 (es) | 1986-01-16 |
| YU44519B (en) | 1990-08-31 |
| CS575883A2 (en) | 1985-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050820 |