ES8602795A1 - Un procedimiento para la preparacion de derivados pentaciclicos - Google Patents

Un procedimiento para la preparacion de derivados pentaciclicos

Info

Publication number
ES8602795A1
ES8602795A1 ES526294A ES526294A ES8602795A1 ES 8602795 A1 ES8602795 A1 ES 8602795A1 ES 526294 A ES526294 A ES 526294A ES 526294 A ES526294 A ES 526294A ES 8602795 A1 ES8602795 A1 ES 8602795A1
Authority
ES
Spain
Prior art keywords
alkyl
substd
opt
alkoxy
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526294A
Other languages
English (en)
Other versions
ES526294A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8602795A1 publication Critical patent/ES8602795A1/es
Publication of ES526294A0 publication Critical patent/ES526294A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS PENTACICLICOS.CONSISTE EN CICLIZAR UN COMPUESTO DE FORMULA (II), EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE ORGANICA O INORGANICA, COMO HIDROXIDO DE SODIO ETANOLICO, A UNA TEMPERATURA ENTRE -20 Y 120 C, PARA OBTENER UN COMPUESTO DE FORMULA (I) O UN N-OXIDO O UNA SAL DEL MISMO, FARMACEUTICAMENTE ACEPTABLE. SIENDO L9 UN GRUPO SALIENTE; A Y B DECLARAN LA POSICION TRANS DEL ATOMO DE H DE CA RESPECTO A CB; R, H O ALQUILO DE C 1 A 7 Y OTROS; R1 ES R1 O ALCOXI DE C 1 A 4; R2 Y R3 INDEPENDIENTEMENTE, H, HIDROXI, Y OTROS; V Y W, H, Y (CH2)2 L9; M ES 1, 2, 3; Y N ES 1 O 2.
ES526294A 1982-03-05 1983-10-06 Un procedimiento para la preparacion de derivados pentaciclicos Granted ES526294A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8206568 1982-03-05

Publications (2)

Publication Number Publication Date
ES8602795A1 true ES8602795A1 (es) 1985-11-16
ES526294A0 ES526294A0 (es) 1985-11-16

Family

ID=10528815

Family Applications (3)

Application Number Title Priority Date Filing Date
ES520338A Granted ES520338A0 (es) 1982-03-05 1983-03-04 Un procedimiento para la preparacion de derivados pentaciclicos.
ES526293A Granted ES526293A0 (es) 1982-03-05 1983-10-06 Un procedimiento para la preparacion de derivados pentaciclicos
ES526294A Granted ES526294A0 (es) 1982-03-05 1983-10-06 Un procedimiento para la preparacion de derivados pentaciclicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES520338A Granted ES520338A0 (es) 1982-03-05 1983-03-04 Un procedimiento para la preparacion de derivados pentaciclicos.
ES526293A Granted ES526293A0 (es) 1982-03-05 1983-10-06 Un procedimiento para la preparacion de derivados pentaciclicos

Country Status (17)

Country Link
US (3) US4504480A (es)
EP (1) EP0088575B1 (es)
JP (1) JPS58162590A (es)
KR (1) KR840004109A (es)
AU (1) AU1204983A (es)
CA (1) CA1196328A (es)
DE (1) DE3368634D1 (es)
DK (1) DK108283A (es)
ES (3) ES520338A0 (es)
FI (1) FI830724L (es)
GR (1) GR77959B (es)
IL (1) IL68014A0 (es)
NO (1) NO830735L (es)
NZ (1) NZ203458A (es)
PT (1) PT76341B (es)
YU (1) YU52483A (es)
ZA (1) ZA831453B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088575B1 (en) * 1982-03-05 1986-12-30 Beecham Group Plc Pentacyclic compounds
GB8405954D0 (en) * 1984-03-07 1984-04-11 Beecham Group Plc Treatment of diarrhoea
US4769368A (en) * 1986-02-10 1988-09-06 Smithkline Beckman Corporation 2,3,4,8,9,9A-Hexahydro-4-aryl-1H-indeno(1,7-CD)azepines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129434C (es) * 1966-03-12
NL154511B (nl) * 1967-07-07 1977-09-15 Organon Nv Werkwijze ter bereiding van piperazinederivaten, werkwijze ter bereiding van een farmaceutisch preparaat, dat een dergelijke verbinding bevat en vormstukken bereid volgens deze werkwijze.
BE791474A (fr) * 1971-11-25 1973-03-16 Yamanouchi Pharma Co Ltd Procede de preparation de derives d'acides cycloalcoylaminoarylcarboxyliques
NL179906C (nl) * 1974-02-09 1986-12-01 Akzo Nv Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten.
US4316900A (en) * 1977-10-05 1982-02-23 Ciba-Geigy Corporation Piperazinopyrrolobenzodiazepines
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
GB2091247B (en) * 1980-12-31 1984-07-18 Beecham Group Ltd Pentacyclic compounds processes for their preparation and their use
EP0088575B1 (en) * 1982-03-05 1986-12-30 Beecham Group Plc Pentacyclic compounds
EP0090552A3 (en) * 1982-03-27 1984-04-25 Beecham Group Plc Pentacyclic compounds

Also Published As

Publication number Publication date
EP0088575A2 (en) 1983-09-14
ES8600291A1 (es) 1985-10-01
DK108283D0 (da) 1983-03-03
US4504480A (en) 1985-03-12
US4585588A (en) 1986-04-29
CA1196328A (en) 1985-11-05
ES8501396A1 (es) 1984-11-16
JPS58162590A (ja) 1983-09-27
ES520338A0 (es) 1984-11-16
US4638066A (en) 1987-01-20
NO830735L (no) 1983-09-06
IL68014A0 (en) 1983-06-15
FI830724A0 (fi) 1983-03-03
EP0088575A3 (en) 1984-07-11
NZ203458A (en) 1986-11-12
GR77959B (es) 1984-09-25
AU1204983A (en) 1983-09-08
FI830724L (fi) 1983-09-06
PT76341B (en) 1985-11-28
DK108283A (da) 1983-09-06
KR840004109A (ko) 1984-10-06
PT76341A (en) 1983-04-01
ES526293A0 (es) 1985-10-01
DE3368634D1 (en) 1987-02-05
YU52483A (en) 1989-08-31
EP0088575B1 (en) 1986-12-30
ZA831453B (en) 1983-12-28
ES526294A0 (es) 1985-11-16

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