ES8602662A1 - Derivados de la 1, 4-dihidropiridina - Google Patents

Derivados de la 1, 4-dihidropiridina

Info

Publication number
ES8602662A1
ES8602662A1 ES534508A ES534508A ES8602662A1 ES 8602662 A1 ES8602662 A1 ES 8602662A1 ES 534508 A ES534508 A ES 534508A ES 534508 A ES534508 A ES 534508A ES 8602662 A1 ES8602662 A1 ES 8602662A1
Authority
ES
Spain
Prior art keywords
alkyl
dihydropyridines
medicaments
preparation
haloalkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534508A
Other languages
English (en)
Other versions
ES534508A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8602662A1 publication Critical patent/ES8602662A1/es
Publication of ES534508A0 publication Critical patent/ES534508A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE MEDICAMENTOS A BASE DE DERIVADOS DE LA 1,4-DIHIDROPIRIDINA.CONSISTE EN HACER REACCIONAR ESTERES DEL ACIDO AMINOCROTONICO DE FORMULA (II) CON ALDEHIDOS DE FORMULA (III), EN DISOLVENTE COMO ALCOHOLES INFERIORES, DIOXANO, ACETONITRILO, PIRIDINA, SULFOXIDO DE DIMETILO Y TETRAHIDROFURANO A TEMPERATURA COMPRENDIDA ENTRE 20 Y 150 C, PARA OBTENER DERIVADOS DE 1,4-DIHIDROPIRIDINA FARMACOLOGICAMENTE ACEPTABLES DE FORMULA (I). SIENDO: R1 Y R2, H, ALQUILO DE C 1 A 4, Y OTROS; R4 Y R5, L, ALCOXI DE C 1 A 6, Y OTROS; R3, RESTO, MONO O DISACARIDO; A, ALQUILENO DE C 2 A 10; Y X, AZUFRE, OXIGENO, O NR6, DONDE R6 ES ALQUILO DE C 1 A 6.SE UTILIZAN PARA MEJORAR LA CONTRACTILIDAD CARDIACA, AUMENTAR LA PRESION SANGUINEA, BAJAR EL AZUCAR DE LA SANGRE, PARA REDUCIR LA HINCHAZON DE LAS MEMBRANAS MUCOSAS, Y PARA INFLUENCIAR EL BALANCE DE SAL Y DE LIQUIDOS.
ES534508A 1983-07-22 1984-07-20 Derivados de la 1, 4-dihidropiridina Granted ES534508A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833326384 DE3326384A1 (de) 1983-07-22 1983-07-22 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (2)

Publication Number Publication Date
ES8602662A1 true ES8602662A1 (es) 1985-12-01
ES534508A0 ES534508A0 (es) 1985-12-01

Family

ID=6204598

Family Applications (3)

Application Number Title Priority Date Filing Date
ES534508A Granted ES534508A0 (es) 1983-07-22 1984-07-20 Derivados de la 1, 4-dihidropiridina
ES543742A Expired ES8604150A1 (es) 1983-07-22 1985-05-31 Un procedimiento para la preparacion de medicamentos a base de derivados de la 1,4-dihidropiridina
ES543741A Expired ES8604149A1 (es) 1983-07-22 1985-05-31 Un procedimiento para la preparacion de medicamentos a base de derivados de la 1,4-dihidropiridina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES543742A Expired ES8604150A1 (es) 1983-07-22 1985-05-31 Un procedimiento para la preparacion de medicamentos a base de derivados de la 1,4-dihidropiridina
ES543741A Expired ES8604149A1 (es) 1983-07-22 1985-05-31 Un procedimiento para la preparacion de medicamentos a base de derivados de la 1,4-dihidropiridina

Country Status (14)

Country Link
US (1) US4537881A (es)
EP (1) EP0139859B1 (es)
JP (1) JPS6042393A (es)
KR (1) KR850001204A (es)
AT (1) ATE38041T1 (es)
AU (1) AU564069B2 (es)
CA (1) CA1229590A (es)
DE (2) DE3326384A1 (es)
ES (3) ES534508A0 (es)
GR (1) GR82104B (es)
HU (1) HUT36092A (es)
IL (1) IL72454A (es)
PT (1) PT78947B (es)
ZA (1) ZA845626B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT39179A (en) * 1984-12-10 1986-08-28 Sandoz Ag Process for production of derivatives of 1,4-dihydro-piridin
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
JPH02167262A (ja) * 1988-06-05 1990-06-27 Taisho Pharmaceut Co Ltd １，４―ジヒドロピリジン誘導体
US5166148A (en) * 1990-07-09 1992-11-24 The Du Pont Merck Pharmaceutical Company 2-amino-1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2641746C2 (de) * 1976-09-16 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-Zuckerderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
PT78947A (en) 1984-08-01
HUT36092A (en) 1985-08-28
JPS6042393A (ja) 1985-03-06
ES8604149A1 (es) 1986-01-16
ZA845626B (en) 1985-03-27
IL72454A (en) 1987-11-30
EP0139859A2 (de) 1985-05-08
AU3088784A (en) 1985-01-24
CA1229590A (en) 1987-11-24
DE3474669D1 (en) 1988-11-24
EP0139859B1 (de) 1988-10-19
US4537881A (en) 1985-08-27
DE3326384A1 (de) 1985-01-31
ES534508A0 (es) 1985-12-01
PT78947B (en) 1986-06-02
IL72454A0 (en) 1984-11-30
KR850001204A (ko) 1985-03-16
ATE38041T1 (de) 1988-11-15
ES8604150A1 (es) 1986-01-16
GR82104B (es) 1984-12-13
EP0139859A3 (en) 1986-08-20
ES543741A0 (es) 1986-01-16
AU564069B2 (en) 1987-07-30
ES543742A0 (es) 1986-01-16

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