ES8602655A1 - Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituido - Google Patents
Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituidoInfo
- Publication number
- ES8602655A1 ES8602655A1 ES530186A ES530186A ES8602655A1 ES 8602655 A1 ES8602655 A1 ES 8602655A1 ES 530186 A ES530186 A ES 530186A ES 530186 A ES530186 A ES 530186A ES 8602655 A1 ES8602655 A1 ES 8602655A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- phenyl
- benzyl
- enantiomers
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN ENANTIOMERO PURO DE UN FENILAZACICLOALCANO SUSTITUIDO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (I) DE FORMA ENANTIOMERA (-) DONDE Y ES OH, EN UN DISOLVENTE ORGANICO, A TEMPERATURA DE REFLUJO DE LA MEZCLA, DURANTE 24 HORAS, CON UN HALURO DE FORMULA R1COX O ANHIDRIDO (R1CO)2O DE ACIDO CARBOXILICO APROPIADO, O CON UN HALURO DE CARBAMOILO R2R3NCOX O ISOCIANATO R2NCO, EN PRESENCIA DE UNA BASE COMO TRIETILAMINA O PIRIDINA, O UN ACIDO, COMO SO4H2 O CF3COOH O CON UN HALURO DE ALILO R4X PARA OBTENER UN COMPUESTO DE LA MISMA FORMULA (I) Y LA MISMA CONFIGURACION ABSOLUTA EN EL ATOMO DE C ASIMETRICO (*) DONDE Y ES R1COOO, R2R3NCOO, O R4O. SIENDO: R, RESTO ALIFATICO DE C 1 A 17; R2, H, GRUPO ALCOHILO DE C 1 A 5 Y OTROS; R3, H, FENILO, Y OTROS; R4, GRUPO ALILO O BENCILO; Y X, HAL. SE UTILIZAN PARA TRATAR TRASTORNOS PSICOTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8202023A SE446335B (sv) | 1982-03-30 | 1982-03-30 | Ren enantiomer av en metasubstituerad 3-fenyl-1-propylpiperidin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES530186A0 ES530186A0 (es) | 1985-12-01 |
| ES8602655A1 true ES8602655A1 (es) | 1985-12-01 |
Family
ID=20346417
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521080A Granted ES521080A0 (es) | 1982-03-30 | 1983-03-29 | Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituido. |
| ES530186A Expired ES8602655A1 (es) | 1982-03-30 | 1984-03-01 | Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituido |
| ES539031A Granted ES539031A0 (es) | 1982-03-30 | 1984-12-24 | Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituido |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES521080A Granted ES521080A0 (es) | 1982-03-30 | 1983-03-29 | Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituido. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539031A Granted ES539031A0 (es) | 1982-03-30 | 1984-12-24 | Un procedimiento para preparar un enantiomero puro de un fenilazacicloalcano sustituido |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0097628B1 (es) |
| JP (1) | JPS58177971A (es) |
| AT (1) | ATE56705T1 (es) |
| AU (1) | AU564287B2 (es) |
| CA (1) | CA1202307A (es) |
| DD (1) | DD209621A5 (es) |
| DE (1) | DE3381885D1 (es) |
| DK (1) | DK162214C (es) |
| ES (3) | ES521080A0 (es) |
| FI (1) | FI81088C (es) |
| GB (1) | GB2117771B (es) |
| GR (1) | GR79244B (es) |
| HU (1) | HU191290B (es) |
| IE (1) | IE55261B1 (es) |
| NO (1) | NO164024C (es) |
| PT (1) | PT76481B (es) |
| SE (1) | SE446335B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8305362D0 (sv) * | 1983-09-30 | 1983-09-30 | Astra Laekemedel Ab | Novel substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds |
| SE9904724D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| JP2011057619A (ja) * | 2009-09-10 | 2011-03-24 | Tokai Univ | 光学活性アミン化合物の製造方法、並びに、ジアステレオマー塩及びその製造方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3070247D1 (en) * | 1979-12-05 | 1985-04-04 | Astra Laekemedel Ab | New phenyl-azacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds |
-
1982
- 1982-03-30 SE SE8202023A patent/SE446335B/sv unknown
-
1983
- 1983-03-23 NO NO831040A patent/NO164024C/no unknown
- 1983-03-25 AU AU12845/83A patent/AU564287B2/en not_active Ceased
- 1983-03-28 IE IE685/83A patent/IE55261B1/en not_active IP Right Cessation
- 1983-03-28 EP EP83850084A patent/EP0097628B1/en not_active Expired - Lifetime
- 1983-03-28 DE DE8383850084T patent/DE3381885D1/de not_active Expired - Fee Related
- 1983-03-28 AT AT83850084T patent/ATE56705T1/de not_active IP Right Cessation
- 1983-03-29 HU HU831073A patent/HU191290B/hu not_active IP Right Cessation
- 1983-03-29 DK DK143483A patent/DK162214C/da not_active IP Right Cessation
- 1983-03-29 FI FI831068A patent/FI81088C/fi not_active IP Right Cessation
- 1983-03-29 CA CA000424804A patent/CA1202307A/en not_active Expired
- 1983-03-29 GB GB08308657A patent/GB2117771B/en not_active Expired
- 1983-03-29 GR GR70924A patent/GR79244B/el unknown
- 1983-03-29 JP JP58051781A patent/JPS58177971A/ja active Granted
- 1983-03-29 ES ES521080A patent/ES521080A0/es active Granted
- 1983-03-30 PT PT76481A patent/PT76481B/pt not_active IP Right Cessation
- 1983-03-30 DD DD83249351A patent/DD209621A5/de not_active IP Right Cessation
-
1984
- 1984-03-01 ES ES530186A patent/ES8602655A1/es not_active Expired
- 1984-12-24 ES ES539031A patent/ES539031A0/es active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001102 |