ES8602618A1 - Procedimiento perfeccionado para la fabricacion de cristales de bestatina en forma v - Google Patents

Procedimiento perfeccionado para la fabricacion de cristales de bestatina en forma v

Info

Publication number
ES8602618A1
ES8602618A1 ES530642A ES530642A ES8602618A1 ES 8602618 A1 ES8602618 A1 ES 8602618A1 ES 530642 A ES530642 A ES 530642A ES 530642 A ES530642 A ES 530642A ES 8602618 A1 ES8602618 A1 ES 8602618A1
Authority
ES
Spain
Prior art keywords
bestatin
processes
preparation
crystalline gamma
gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530642A
Other languages
English (en)
Other versions
ES530642A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8602618A1 publication Critical patent/ES8602618A1/es
Publication of ES530642A0 publication Critical patent/ES530642A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA FABRICACION DE CRISTALES DE BESTATINA EN FORMA V. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE PREPARA UNO O VARIOS DISOLVENTES SELECCIONADOS ENTRE ACETONA, METILETIL CETONA, DIETILCETONA, TETRAHIDROFURANO, ACETATO DE ETILO, DIOXANO, ALCOHOL ISOPROPILICO Y METANOL Y SE FORMA CON ELLOS UNA SOLUCION ACUOSA; SEGUNDA, SE PREPARA UN CRISTAL HIGROSCOPICO DE BESTIATINA O DE HIDRATO DE LA MISMA; Y POR ULTIMO, SE PROCEDE A LA SUSPENSION DE DICHO CRISTAL HIGROSCOPICO DE BESTATINA O DE HIDRATO DE LA MISMA, EN LA SOLUCION ACUOSA PREPARADA Y SE MANTIENE DICHA SUSPENSION DURANTE UN PERIODO DE TIEMPO SUPERIOR A 10 MINUTOS. DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS.
ES530642A 1981-12-24 1984-03-15 Procedimiento perfeccionado para la fabricacion de cristales de bestatina en forma v Granted ES530642A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56208144A JPS58110553A (ja) 1981-12-24 1981-12-24 ベスタチンのγ型結晶及びその製造法

Publications (2)

Publication Number Publication Date
ES8602618A1 true ES8602618A1 (es) 1985-12-16
ES530642A0 ES530642A0 (es) 1985-12-16

Family

ID=16551358

Family Applications (2)

Application Number Title Priority Date Filing Date
ES518517A Granted ES518517A0 (es) 1981-12-24 1982-12-23 Procedimiento para la fabricacion de cristales de bestatina en forma v.
ES530642A Granted ES530642A0 (es) 1981-12-24 1984-03-15 Procedimiento perfeccionado para la fabricacion de cristales de bestatina en forma v

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES518517A Granted ES518517A0 (es) 1981-12-24 1982-12-23 Procedimiento para la fabricacion de cristales de bestatina en forma v.

Country Status (13)

Country Link
US (2) US4769490A (es)
JP (1) JPS58110553A (es)
CH (1) CH652727A5 (es)
CS (1) CS236866B2 (es)
DE (1) DE3246135C2 (es)
DK (2) DK161094C (es)
ES (2) ES518517A0 (es)
FR (1) FR2518989B1 (es)
GB (1) GB2111991B (es)
HU (1) HU187831B (es)
IT (1) IT1155439B (es)
NL (1) NL8204951A (es)
SE (1) SE453508B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106631880B (zh) * 2016-08-01 2018-06-01 四川青木制药有限公司 一种乌苯美司δ晶型及其制备方法
CN113563221A (zh) * 2018-07-09 2021-10-29 成都苑东生物制药股份有限公司 一种乌苯美司γ晶型的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5439477B2 (es) * 1974-07-01 1979-11-28
US4052449A (en) * 1974-07-01 1977-10-04 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Biologically active substance, bestatin, and production thereof
US4189604A (en) * 1975-07-22 1980-02-19 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Bestatin
GB1540019A (en) * 1977-06-01 1979-02-07 Microbial Chem Res Found Bestatin derivatives
CH650265A5 (de) * 1978-11-25 1985-07-15 Nippon Kayaku Kk Verfahren zur herstellung von substituierten threo-3-amino-2-hydroxybutanoylaminoessigsaeuren.
JPS5767516A (en) * 1980-09-24 1982-04-24 Microbial Chem Res Found Novel analgesic agent

Also Published As

Publication number Publication date
SE8207338L (sv) 1983-06-25
DK236690D0 (da) 1990-10-01
IT1155439B (it) 1987-01-28
SE8207338D0 (sv) 1982-12-22
CH652727A5 (de) 1985-11-29
HU187831B (en) 1986-02-28
DE3246135A1 (de) 1983-07-07
US4786754A (en) 1988-11-22
FR2518989B1 (fr) 1986-10-31
GB2111991A (en) 1983-07-13
JPS58110553A (ja) 1983-07-01
DK161972C (da) 1992-02-03
DK161972B (da) 1991-09-02
ES8405855A1 (es) 1984-06-16
ES518517A0 (es) 1984-06-16
CS236866B2 (en) 1985-05-15
DK161094C (da) 1991-11-04
ES530642A0 (es) 1985-12-16
DK161094B (da) 1991-05-27
FR2518989A1 (fr) 1983-07-01
NL8204951A (nl) 1983-07-18
SE453508B (sv) 1988-02-08
DK545082A (da) 1983-06-25
US4769490A (en) 1988-09-06
DK236690A (da) 1990-10-01
IT8224919A0 (it) 1982-12-22
DE3246135C2 (de) 1995-11-30
IT8224919A1 (it) 1984-06-22
GB2111991B (en) 1985-06-26
JPS6351145B2 (es) 1988-10-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103