ES8405855A1 - Procedimiento para la fabricacion de cristales de bestatina en forma v. - Google Patents
Procedimiento para la fabricacion de cristales de bestatina en forma v.Info
- Publication number
- ES8405855A1 ES8405855A1 ES518517A ES518517A ES8405855A1 ES 8405855 A1 ES8405855 A1 ES 8405855A1 ES 518517 A ES518517 A ES 518517A ES 518517 A ES518517 A ES 518517A ES 8405855 A1 ES8405855 A1 ES 8405855A1
- Authority
- ES
- Spain
- Prior art keywords
- bestatin
- processes
- preparation
- crystalline gamma
- gamma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE CRISTALES ESTABLES EN FORMA BGB DE LA BESTATINA.EL CRISTAL EN FORMA BGB PUEDE SER PREPARADO POR CALENTAMIENTO DE UN CRISTAL HIDROSCOPICO DE BESTATINA O DE UN HIDRATO DEL MISMO, A UNA TEMPERATURA COMPRENDIDA ENTRE 148 GRADOS Y EL PUNTO DE FUSION DE LA BESTATINA, O SUSPENDIENDO UN CRISTAL HIGROSCOPICO DE BESTATINA O DE UN HIDRATO DEL MISMO, EN UNO O VARIOS DISOLVENTES ESCOGIDOS ENTRE ACETONA, METIL ETIL CETONA, DIETIL CETONA, TETRAHIDROFURANO, ACETATO DE ETILO, DIOXANO, ALCOHOL ISOPROPILICO Y METANOL ACUOSO, O AMASANDO UN CRISTALHIGROSCOPICO DE BESTATINA O DE UN HIDRATO DE LA MISMA, CON DICHOS DISOLVENTES ORGANICOS.DE APLICACION EN LA PREPARACION DE DOSIFICACIONES FARMACEUTICAS QUE CONTENGAN BESTATINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56208144A JPS58110553A (ja) | 1981-12-24 | 1981-12-24 | ベスタチンのγ型結晶及びその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8405855A1 true ES8405855A1 (es) | 1984-06-16 |
| ES518517A0 ES518517A0 (es) | 1984-06-16 |
Family
ID=16551358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES518517A Granted ES518517A0 (es) | 1981-12-24 | 1982-12-23 | Procedimiento para la fabricacion de cristales de bestatina en forma v. |
| ES530642A Granted ES530642A0 (es) | 1981-12-24 | 1984-03-15 | Procedimiento perfeccionado para la fabricacion de cristales de bestatina en forma v |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES530642A Granted ES530642A0 (es) | 1981-12-24 | 1984-03-15 | Procedimiento perfeccionado para la fabricacion de cristales de bestatina en forma v |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US4769490A (es) |
| JP (1) | JPS58110553A (es) |
| CH (1) | CH652727A5 (es) |
| CS (1) | CS236866B2 (es) |
| DE (1) | DE3246135C2 (es) |
| DK (2) | DK161094C (es) |
| ES (2) | ES518517A0 (es) |
| FR (1) | FR2518989B1 (es) |
| GB (1) | GB2111991B (es) |
| HU (1) | HU187831B (es) |
| IT (1) | IT1155439B (es) |
| NL (1) | NL8204951A (es) |
| SE (1) | SE453508B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106631880B (zh) * | 2016-08-01 | 2018-06-01 | 四川青木制药有限公司 | 一种乌苯美司δ晶型及其制备方法 |
| CN113563221A (zh) * | 2018-07-09 | 2021-10-29 | 成都苑东生物制药股份有限公司 | 一种乌苯美司γ晶型的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052449A (en) * | 1974-07-01 | 1977-10-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Biologically active substance, bestatin, and production thereof |
| JPS5439477B2 (es) * | 1974-07-01 | 1979-11-28 | ||
| US4189604A (en) * | 1975-07-22 | 1980-02-19 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin |
| GB1540019A (en) * | 1977-06-01 | 1979-02-07 | Microbial Chem Res Found | Bestatin derivatives |
| ES486572A1 (es) * | 1978-11-25 | 1980-09-16 | Nippon Kayaku Kk | Procedimiento para la fabricacion de acidos treo-3-amino-2- hidroxibutanoil amonoaceticos. |
| JPS5767516A (en) * | 1980-09-24 | 1982-04-24 | Microbial Chem Res Found | Novel analgesic agent |
-
1981
- 1981-12-24 JP JP56208144A patent/JPS58110553A/ja active Granted
-
1982
- 1982-12-08 DK DK545082A patent/DK161094C/da not_active IP Right Cessation
- 1982-12-14 GB GB08235642A patent/GB2111991B/en not_active Expired
- 1982-12-14 DE DE3246135A patent/DE3246135C2/de not_active Expired - Fee Related
- 1982-12-22 SE SE8207338A patent/SE453508B/sv not_active IP Right Cessation
- 1982-12-22 CH CH7507/82A patent/CH652727A5/de not_active IP Right Cessation
- 1982-12-22 CS CS829557A patent/CS236866B2/cs unknown
- 1982-12-22 NL NL8204951A patent/NL8204951A/nl not_active Application Discontinuation
- 1982-12-22 IT IT24919/82A patent/IT1155439B/it active
- 1982-12-23 FR FR8221680A patent/FR2518989B1/fr not_active Expired
- 1982-12-23 ES ES518517A patent/ES518517A0/es active Granted
- 1982-12-23 HU HU824158A patent/HU187831B/hu unknown
-
1984
- 1984-03-15 ES ES530642A patent/ES530642A0/es active Granted
-
1987
- 1987-04-02 US US07/033,277 patent/US4769490A/en not_active Expired - Fee Related
- 1987-07-13 US US07/072,370 patent/US4786754A/en not_active Expired - Lifetime
-
1990
- 1990-10-01 DK DK236690A patent/DK161972C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT1155439B (it) | 1987-01-28 |
| DK545082A (da) | 1983-06-25 |
| DK161094C (da) | 1991-11-04 |
| GB2111991A (en) | 1983-07-13 |
| DK161094B (da) | 1991-05-27 |
| IT8224919A1 (it) | 1984-06-22 |
| CH652727A5 (de) | 1985-11-29 |
| ES8602618A1 (es) | 1985-12-16 |
| US4786754A (en) | 1988-11-22 |
| SE8207338D0 (sv) | 1982-12-22 |
| FR2518989A1 (fr) | 1983-07-01 |
| DE3246135A1 (de) | 1983-07-07 |
| ES530642A0 (es) | 1985-12-16 |
| FR2518989B1 (fr) | 1986-10-31 |
| JPS58110553A (ja) | 1983-07-01 |
| CS236866B2 (en) | 1985-05-15 |
| NL8204951A (nl) | 1983-07-18 |
| GB2111991B (en) | 1985-06-26 |
| US4769490A (en) | 1988-09-06 |
| DK161972B (da) | 1991-09-02 |
| DE3246135C2 (de) | 1995-11-30 |
| SE453508B (sv) | 1988-02-08 |
| SE8207338L (sv) | 1983-06-25 |
| DK236690D0 (da) | 1990-10-01 |
| DK161972C (da) | 1992-02-03 |
| ES518517A0 (es) | 1984-06-16 |
| IT8224919A0 (it) | 1982-12-22 |
| HU187831B (en) | 1986-02-28 |
| DK236690A (da) | 1990-10-01 |
| JPS6351145B2 (es) | 1988-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041102 |