ES8601993A1 - Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina. - Google Patents
Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina.Info
- Publication number
- ES8601993A1 ES8601993A1 ES540638A ES540638A ES8601993A1 ES 8601993 A1 ES8601993 A1 ES 8601993A1 ES 540638 A ES540638 A ES 540638A ES 540638 A ES540638 A ES 540638A ES 8601993 A1 ES8601993 A1 ES 8601993A1
- Authority
- ES
- Spain
- Prior art keywords
- pterin
- erythro
- dihydroxypropyl
- tetrahydro
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 5,6,7,8-TETRAHIDRO-6-(L-ERITRO-1,2-DIHIDROXIPROPIL)-PTERINA, DE FORMULA (I), RICA EN LA FORMULA (6R). CONSISTE EN LA REACCION DE HIDROGENACION DE 6-(L-ERITRO-1,2-DIHIDROXIPROPIL)-PTERINA, DE FORMULA (II). LA REACCION SE LLEVA A CABO EN DISOLUCION ACUOSA, EN UN MEDIO BASICO CON UNA SAL DE METAL ALCALINO DE UN ACIDO DEBIL O UN HIDROXIDO ALCALINO O ALCALINOTERREO, EN PRESENCIA DE UN CATALIZADOR DEL GRUPO DEL PLATINO, QUE PUEDE ESTAR SOPORTADO SOBRE CARBONO O ALGODON, A UNA TEMPERATURA COMPRENDIDA ENTRE 0C Y 50C. EL PRODUCTO OBTENIDO SE AISLA Y PURIFICA MEDIANTE CRISTALIZACION. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59033839A JPS60178887A (ja) | 1984-02-23 | 1984-02-23 | 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8601993A1 true ES8601993A1 (es) | 1985-11-16 |
ES540638A0 ES540638A0 (es) | 1985-11-16 |
Family
ID=12397654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES540638A Granted ES540638A0 (es) | 1984-02-23 | 1985-02-22 | Un procedimiento de preparar 5,6,7,8-tetrahidro-6-(l-eritro-1',2'-dihidroxipropil)-pterina. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4595752A (es) |
EP (1) | EP0153696B1 (es) |
JP (1) | JPS60178887A (es) |
AT (1) | ATE46906T1 (es) |
CA (1) | CA1240321A (es) |
DE (1) | DE3573426D1 (es) |
ES (1) | ES540638A0 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法 |
JPS60199889A (ja) * | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−エリスロ−ビオプテリンの硫酸塩およびその製法 |
JPS60204786A (ja) * | 1984-03-29 | 1985-10-16 | Univ Nagoya | (6r)―テトラヒドロビオプテリンの合成法 |
US4665176A (en) * | 1984-10-23 | 1987-05-12 | Mitsui Toatsu Chemicals, Incorporated | Process for the preparation of 5,6,7,8-tetrahydrofolic acid |
CA1262347A (en) * | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
CA1334654C (en) * | 1987-11-30 | 1995-03-07 | Masayasu Kurono | Intermediates for synthesizing bh _and its derivatives |
US6162914A (en) * | 1998-04-24 | 2000-12-19 | Cerbios-Pharma S.A. | Process for the reduction of pterins |
CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
DE60138029D1 (de) | 2000-08-31 | 2009-04-30 | Asubio Pharma Co Ltd | Verfahren zur herstellung von biopterinen |
US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
AU2004291149C1 (en) | 2003-11-17 | 2021-01-21 | Biomarin Pharmaceutical Inc. | Methods and Compositions for the Treatment of Metabolic Disorders |
JP2007536210A (ja) * | 2003-11-17 | 2007-12-13 | メルック・エプロバ・アクチエンゲゼルシヤフト | (6r)−l−エリスロ−テトラヒドロビオプテリンジヒドロクロライドの結晶形 |
WO2006004719A2 (en) * | 2004-06-25 | 2006-01-12 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia |
US8003126B2 (en) | 2004-11-17 | 2011-08-23 | Biomarin Pharmaceutical Inc. | Stable tablet formulation |
CA2588994A1 (en) * | 2004-12-08 | 2006-06-15 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of pulmonary hypertension of the newborn |
PL1869048T3 (pl) | 2005-04-14 | 2009-05-29 | Shiratori Pharmaceutical Co Ltd | Sposób wytwarzania kryształów chlorowodorku sapropteryny w odmianie alfa |
EP1965803A1 (en) * | 2005-12-05 | 2008-09-10 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of disease |
WO2008089148A1 (en) * | 2007-01-12 | 2008-07-24 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug |
EP2114944A2 (en) * | 2007-01-12 | 2009-11-11 | BioMarin Pharmaceutical Inc. | Tetrahydrobiopterin prodrugs |
PT2545939T (pt) | 2007-04-11 | 2021-02-17 | Biomarin Pharm Inc | Métodos de administração de tetra-hidrobiopterina, composições associadas, e métodos de medição |
CN101969953B (zh) * | 2008-01-03 | 2013-01-09 | 生物马林药物股份有限公司 | 用于治疗bh4反应性疾病的喋呤类似物 |
CN101959891A (zh) * | 2008-01-07 | 2011-01-26 | 生物马林药物股份有限公司 | 合成四氢生物蝶呤的方法 |
CN102443006B (zh) | 2010-10-13 | 2016-02-24 | 因华生技制药股份有限公司 | (6r)-四氢生物喋呤盐酸盐的制备方法 |
TWI481612B (zh) * | 2010-10-15 | 2015-04-21 | Innopharmax Inc | (6r)-四氫生物喋呤鹽酸鹽的製備方法 |
US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
CN102627644B (zh) * | 2012-04-10 | 2014-04-16 | 凯莱英医药集团(天津)股份有限公司 | 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法 |
CN102633799B (zh) | 2012-04-10 | 2014-06-25 | 凯莱英医药集团(天津)股份有限公司 | 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法 |
WO2016189542A1 (en) | 2015-05-28 | 2016-12-01 | Natco Pharma Ltd | Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin |
WO2019175328A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4pathwayactivationandusethereoffortreatingcancer |
WO2019175332A1 (en) | 2018-03-14 | 2019-09-19 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2741608A (en) * | 1951-03-08 | 1956-04-10 | Research Corp | 5-formyl-5,6,7,8-tetrahydropteroic acid and amides thereof and method of preparing same |
JPS5883691A (ja) * | 1981-11-13 | 1983-05-19 | Kanegafuchi Chem Ind Co Ltd | 1′,2′−ジアシル−(6r,s)−5,6,7,8−テトラヒドロ−l−ビオプテリンおよびその製法 |
JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法 |
JPS61172876A (ja) * | 1985-01-28 | 1986-08-04 | Shiratori Seiyaku Kk | (6r)−テトラヒドロ−l−バイオプテリンの製造法 |
JPS61172877A (ja) * | 1985-01-28 | 1986-08-04 | Shiratori Seiyaku Kk | (6r)−テトラヒドロ−l−バイオプテリンの製造方法 |
-
1984
- 1984-02-23 JP JP59033839A patent/JPS60178887A/ja active Granted
-
1985
- 1985-02-19 CA CA000474602A patent/CA1240321A/en not_active Expired
- 1985-02-21 AT AT85101861T patent/ATE46906T1/de not_active IP Right Cessation
- 1985-02-21 EP EP85101861A patent/EP0153696B1/en not_active Expired
- 1985-02-21 US US06/703,976 patent/US4595752A/en not_active Expired - Lifetime
- 1985-02-21 DE DE8585101861T patent/DE3573426D1/de not_active Expired
- 1985-02-22 ES ES540638A patent/ES540638A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
EP0153696B1 (en) | 1989-10-04 |
JPH0212475B2 (es) | 1990-03-20 |
EP0153696A2 (en) | 1985-09-04 |
CA1240321A (en) | 1988-08-09 |
ATE46906T1 (de) | 1989-10-15 |
EP0153696A3 (en) | 1987-08-19 |
DE3573426D1 (en) | 1989-11-09 |
US4595752A (en) | 1986-06-17 |
JPS60178887A (ja) | 1985-09-12 |
ES540638A0 (es) | 1985-11-16 |
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