ES8601938A1 - Un procedimiento para preparar derivados de morfolina - Google Patents

Un procedimiento para preparar derivados de morfolina

Info

Publication number
ES8601938A1
ES8601938A1 ES531851A ES531851A ES8601938A1 ES 8601938 A1 ES8601938 A1 ES 8601938A1 ES 531851 A ES531851 A ES 531851A ES 531851 A ES531851 A ES 531851A ES 8601938 A1 ES8601938 A1 ES 8601938A1
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
morpholine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531851A
Other languages
English (en)
Other versions
ES531851A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES531851A0 publication Critical patent/ES531851A0/es
Publication of ES8601938A1 publication Critical patent/ES8601938A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE MORFOLINA. COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O SU SAL CON UN COMPUESTO DE FORMULA (III) O SU SAL, EN UN DISOLVENTE, COMO AGUA, ALCOHOL, TETRAHIDROFURANO, DIOXANO, DIMETILFORMAMIDA, Y OTROS, EN PRESENCIA DE UN ACIDO COMO CLORHIDRICO, SULFURICO, POLIFOSFORICO, ACETICO, BENCENOSULFONICO, A TEMPERATURA AMBIENTE O MODERADAMENTE SUPERIOR, PARA OBTENER UN COMPUESTO DE FORMULA (I) O SU SAL. SIENDO: R1, GRUPO HETEROCICLICO SELECCIONADO DE URACILILO, CITOSINILO, Y OTROS; R2, GRUPO HETEROCICLICO INSATURADO, CON NITROGENO, Y OTROS; Y R3, H, GRUPO FOSFONO. SE UTILIZAN EN FARMACOLOGIA PARA EL TRATAMIENTO TERAPEUTICO DEL CANCER.
ES531851A 1983-04-25 1984-04-24 Un procedimiento para preparar derivados de morfolina Expired ES8601938A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838311228A GB8311228D0 (en) 1983-04-25 1983-04-25 Morpholine derivatives

Publications (2)

Publication Number Publication Date
ES531851A0 ES531851A0 (es) 1985-11-16
ES8601938A1 true ES8601938A1 (es) 1985-11-16

Family

ID=10541654

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531851A Expired ES8601938A1 (es) 1983-04-25 1984-04-24 Un procedimiento para preparar derivados de morfolina

Country Status (8)

Country Link
US (1) US4558047A (es)
EP (1) EP0123473A3 (es)
JP (1) JPS59210082A (es)
KR (1) KR910006865B1 (es)
CA (1) CA1249813A (es)
DK (1) DK205684A (es)
ES (1) ES8601938A1 (es)
GB (1) GB8311228D0 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3022967B2 (ja) * 1985-03-15 2000-03-21 アンチバイラルズ インコーポレイテッド 立体規則性ポリヌクレオチド結合ポリマー
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5235033A (en) * 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5470974A (en) * 1985-03-15 1995-11-28 Neu-Gene Development Group Uncharged polynucleotide-binding polymers
US5405938A (en) * 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5185444A (en) * 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5217866A (en) * 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5506337A (en) * 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
WO1991018898A1 (fr) * 1990-06-01 1991-12-12 Nippon Shinyaku Co., Ltd. Homologue d'acide nucleique
EP4101930A1 (en) * 2015-09-17 2022-12-14 ModernaTX, Inc. Polynucleotides containing a stabilizing tail region

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3532695A (en) * 1967-10-25 1970-10-06 William Dvonch Morpholinoisonicotinamides
US3542776A (en) * 1967-10-25 1970-11-24 American Home Prod Morpholinoisonicotinamides
JPS5461185A (en) * 1977-10-25 1979-05-17 Takeda Chem Ind Ltd Nucleic acid base derivatives

Also Published As

Publication number Publication date
GB8311228D0 (en) 1983-06-02
DK205684D0 (da) 1984-04-24
CA1249813A (en) 1989-02-07
EP0123473A3 (en) 1987-07-29
US4558047A (en) 1985-12-10
JPS59210082A (ja) 1984-11-28
ES531851A0 (es) 1985-11-16
KR910006865B1 (ko) 1991-09-09
KR840008342A (ko) 1984-12-14
DK205684A (da) 1984-10-26
EP0123473A2 (en) 1984-10-31

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