ES8601840A1 - Procedimiento para la preparacion de derivados de carbaci- clina - Google Patents
Procedimiento para la preparacion de derivados de carbaci- clinaInfo
- Publication number
- ES8601840A1 ES8601840A1 ES540852A ES540852A ES8601840A1 ES 8601840 A1 ES8601840 A1 ES 8601840A1 ES 540852 A ES540852 A ES 540852A ES 540852 A ES540852 A ES 540852A ES 8601840 A1 ES8601840 A1 ES 8601840A1
- Authority
- ES
- Spain
- Prior art keywords
- aryl
- alkyl
- opt
- heterocyclic
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical compound C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 abstract 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- CCGKOQOJPYTBIH-UHFFFAOYSA-N ethenone Chemical compound C=C=O CCGKOQOJPYTBIH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- -1 hydroxymethylene Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Drawers Of Furniture (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CARBACICLINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN REACTIVO DE WITTING DE FORMULA (III), EN UN DISOLVENTE APROTICO O EN UNA MEZCLA DE DISOLVENTES APROTICOS, A UNA TEMPERATURA DE 0C HASTA 100C, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: A, GRUPO-CH2-CH2-TRANS-CH CH O C C; B), DOBLE ENLACE TRANS O TRIPLE ENLACE O GRUPO C CBR; D, GRUPO DE FORMULA (IV), GRUPO ALQUILENO CON C 1 A 5 SATURADO DE CADENA LINEAL U OTROS; E, GRUPO C C O CH2-CH2; N, 1, 2 O 3; R1, RADICAL OR2 O RADICAL R3, R2, H, RADICAL ALQUILO DE C 1 A 10 Y OTROS; R3, RADICAL ALQUILO DE C 1 A 10 U OTROS; R4, GRUPO ALQUILO DE C 1 A 10, CICLOALQUILO DE C 3 A 10 U OTROS; R5, GRUPO HIDROXI LIBRE; Y W GRUPO HIDROXIMETILENO LIBRE O FUNCIONALMENTE MODIFICADO U OTROS. SE UTILIZA COMO MEDICAMENTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843408699 DE3408699A1 (de) | 1984-03-08 | 1984-03-08 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES540852A0 ES540852A0 (es) | 1985-12-01 |
| ES8601840A1 true ES8601840A1 (es) | 1985-12-01 |
Family
ID=6230046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540852A Expired ES8601840A1 (es) | 1984-03-08 | 1985-03-01 | Procedimiento para la preparacion de derivados de carbaci- clina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4827017A (es) |
| EP (1) | EP0155901B1 (es) |
| JP (1) | JPH0723336B2 (es) |
| AT (1) | ATE63305T1 (es) |
| AU (1) | AU577097B2 (es) |
| CA (1) | CA1263382A (es) |
| CS (1) | CS250247B2 (es) |
| DD (1) | DD234414A5 (es) |
| DE (2) | DE3408699A1 (es) |
| DK (1) | DK101085A (es) |
| ES (1) | ES8601840A1 (es) |
| FI (1) | FI850885L (es) |
| GR (1) | GR850567B (es) |
| HU (1) | HU195481B (es) |
| IE (1) | IE58007B1 (es) |
| IL (1) | IL74542A0 (es) |
| NO (1) | NO160438C (es) |
| NZ (1) | NZ211291A (es) |
| PH (1) | PH23067A (es) |
| ZA (1) | ZA851771B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3428266A1 (de) * | 1984-07-27 | 1986-01-30 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
| IL65387A0 (en) * | 1981-04-14 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | 2,3,4-trinor-m-inter-phenylene-prostaglandin derivatives and a process for the preparation thereof |
| DE3146278C2 (de) * | 1981-11-21 | 1984-10-31 | Grünenthal GmbH, 5190 Stolberg | cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen |
| IL67332A (en) * | 1981-12-01 | 1985-12-31 | Chinoin Gyogyszer Es Vegyeszet | Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them |
| DE3204443A1 (de) * | 1982-02-08 | 1983-08-18 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| HU190007B (en) * | 1982-05-06 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing new aromatic prostacylin analogues |
-
1984
- 1984-03-08 DE DE19843408699 patent/DE3408699A1/de not_active Ceased
-
1985
- 1985-03-01 ES ES540852A patent/ES8601840A1/es not_active Expired
- 1985-03-04 NZ NZ211291A patent/NZ211291A/xx unknown
- 1985-03-05 CS CS851538A patent/CS250247B2/cs unknown
- 1985-03-05 FI FI850885A patent/FI850885L/fi not_active Application Discontinuation
- 1985-03-05 DK DK101085A patent/DK101085A/da not_active Application Discontinuation
- 1985-03-06 DE DE8585730037T patent/DE3582742D1/de not_active Expired - Lifetime
- 1985-03-06 AT AT85730037T patent/ATE63305T1/de not_active IP Right Cessation
- 1985-03-06 EP EP85730037A patent/EP0155901B1/de not_active Expired - Lifetime
- 1985-03-06 DD DD85273815A patent/DD234414A5/de unknown
- 1985-03-06 GR GR850567A patent/GR850567B/el unknown
- 1985-03-07 IE IE576/85A patent/IE58007B1/en not_active IP Right Cessation
- 1985-03-07 CA CA000475928A patent/CA1263382A/en not_active Expired
- 1985-03-07 HU HU85865A patent/HU195481B/hu not_active IP Right Cessation
- 1985-03-07 NO NO850906A patent/NO160438C/no unknown
- 1985-03-08 PH PH31961A patent/PH23067A/en unknown
- 1985-03-08 JP JP60045001A patent/JPH0723336B2/ja not_active Expired - Lifetime
- 1985-03-08 ZA ZA851771A patent/ZA851771B/xx unknown
- 1985-03-08 IL IL74542A patent/IL74542A0/xx unknown
- 1985-03-08 AU AU39734/85A patent/AU577097B2/en not_active Ceased
-
1987
- 1987-03-03 US US07/021,102 patent/US4827017A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI850885L (fi) | 1985-09-09 |
| AU3973485A (en) | 1985-09-12 |
| ES540852A0 (es) | 1985-12-01 |
| ZA851771B (en) | 1985-10-30 |
| JPS60204737A (ja) | 1985-10-16 |
| NO850906L (no) | 1985-09-09 |
| DD234414A5 (de) | 1986-04-02 |
| NO160438C (no) | 1989-04-19 |
| PH23067A (en) | 1989-03-27 |
| DE3582742D1 (de) | 1991-06-13 |
| NZ211291A (en) | 1988-10-28 |
| EP0155901A1 (de) | 1985-09-25 |
| US4827017A (en) | 1989-05-02 |
| NO160438B (no) | 1989-01-09 |
| DE3408699A1 (de) | 1985-09-12 |
| JPH0723336B2 (ja) | 1995-03-15 |
| IE850576L (en) | 1985-09-08 |
| DK101085A (da) | 1985-09-09 |
| DK101085D0 (da) | 1985-03-05 |
| HU195481B (en) | 1988-05-30 |
| CA1263382A (en) | 1989-11-28 |
| IE58007B1 (en) | 1993-06-02 |
| CS250247B2 (en) | 1987-04-16 |
| AU577097B2 (en) | 1988-09-15 |
| FI850885A0 (fi) | 1985-03-05 |
| GR850567B (es) | 1985-07-03 |
| HUT37120A (en) | 1985-11-28 |
| EP0155901B1 (de) | 1991-05-08 |
| IL74542A0 (en) | 1985-06-30 |
| ATE63305T1 (de) | 1991-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT8547664A0 (it) | Composizione acquosa per il trattamento del cavo orale | |
| BE837472A (fr) | Inhalateur pour l'administration de remedes pulverulents | |
| ES511152A0 (es) | "un procedimiento para prepara derivados de fenilciclobutano". | |
| DE3268041D1 (en) | Pharmaceutical preparations containing vicinal dihydroxyalkyl xanthines, process for the preparation of the xanthines and the appropriate intermediates therefor | |
| IT8620902A0 (it) | Composizioni contenenti acido usnico o suoi derivati atte all'impiego nel trattamento della carie dentaria. | |
| IT8024827A0 (it) | Impiego dell'alfa-chetoglutarato di piridossina nella profilassi della iperlattacidemia. | |
| ZA906931B (en) | Reversal of glucocorticoid-induced skin atrophy | |
| DK0506772T3 (da) | Farmaceutisk præparat indeholdende et phosphosukker | |
| AU571841B2 (en) | Carbacyclin pharmaceutical preparations | |
| ES8601840A1 (es) | Procedimiento para la preparacion de derivados de carbaci- clina | |
| SE7607090L (sv) | Oral komposition | |
| EP0676202A3 (fr) | Application de stéroides aromatiques substitués en position 3, par une chaîne aminoalkoxy disubstituée pour obtenir un médicament destiné au contrÔle de la fertilité en particulier de la fertilité masculine. | |
| ES523426A0 (es) | Un metodo para preparar nuevos derivados de guanina | |
| ES8601835A1 (es) | Procedimiento para preparar derivados de carbaciclina | |
| ES8604556A1 (es) | Procedimiento para preparar derivados de flaveno y tioflave-no | |
| DE3361936D1 (en) | 1,1,2-triphenyl-but-1-ene derivatives, process for their preparation and their use as medicines | |
| IT1103104B (it) | Procedimento per la riduzione della viscosita' di composizioni polioliche e composto impiegato | |
| ZA83851B (en) | Carbacyclins, process for the preparation thereof, and use thereof as medicinal agents | |
| AR211019A1 (es) | Un procedimiento de preparacion de derivados de hidroxibencil o hidroxinaftil - tetrahidro - tieno (3,2-c)-piridina | |
| IT1042672B (it) | Procedimento per il miglioramento delle proprieta prenanti delle aste di guida a scorrimento trafilate | |
| FR2258186A1 (en) | 10-((4-hydroxyethylpiperidino)alkyl)-phenothiazines - with antiemetic activity | |
| FR2290907A2 (fr) | Nouveaux derives de la phenothiazine, leur preparation et les compositions qui les contiennent | |
| IE42035L (en) | Isoquinoline derivatives | |
| DE3366233D1 (en) | 6-beta,7-beta-methylene-17-alpha-pregn-4-ene-21,17-carbolactones, their preparation and use as medicinal agents | |
| AU576477B2 (en) | 5-fluoro-carbacyclins |