ES8601141A1 - Un procedimiento para la produccion de derivados de isoquinolina sustituidos - Google Patents
Un procedimiento para la produccion de derivados de isoquinolina sustituidosInfo
- Publication number
- ES8601141A1 ES8601141A1 ES532603A ES532603A ES8601141A1 ES 8601141 A1 ES8601141 A1 ES 8601141A1 ES 532603 A ES532603 A ES 532603A ES 532603 A ES532603 A ES 532603A ES 8601141 A1 ES8601141 A1 ES 8601141A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- procedure
- isoquinoline derivatives
- production
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/496,327 US4544657A (en) | 1983-05-19 | 1983-05-19 | Substituted isoquinolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES532603A0 ES532603A0 (es) | 1985-11-01 |
| ES8601141A1 true ES8601141A1 (es) | 1985-11-01 |
Family
ID=23972146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES532603A Expired ES8601141A1 (es) | 1983-05-19 | 1984-05-18 | Un procedimiento para la produccion de derivados de isoquinolina sustituidos |
Country Status (20)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2124511C1 (ru) * | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| US5681954A (en) * | 1993-05-14 | 1997-10-28 | Daiichi Pharmaceutical Co., Ltd. | Piperazine derivatives |
| PL319511A1 (en) * | 1994-10-05 | 1997-08-18 | Glaxo Wellcome Inc | Parenteral pharmaceutic compositions containing gf120918a |
| FR2840896B1 (fr) * | 2002-06-18 | 2005-04-08 | Sanofi Synthelabo | Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| AU2006274884B2 (en) | 2005-07-29 | 2012-04-05 | F. Hoffmann-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759443A (fr) * | 1970-09-15 | 1971-04-30 | I F L O Istituto Farmacologico | Nouveau derive papaverolinique et procede de preparation relatif |
| DE2818423A1 (de) * | 1978-04-27 | 1979-11-08 | Hoechst Ag | Neue isochinolinderivate und verfahren zu ihrer herstellung |
| IN154317B (enrdf_load_html_response) * | 1979-07-19 | 1984-10-13 | Andre Buzas | |
| DE3034001A1 (de) * | 1980-09-10 | 1982-04-22 | Hoechst Ag, 6000 Frankfurt | Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung |
-
1983
- 1983-05-19 US US06/496,327 patent/US4544657A/en not_active Expired - Fee Related
-
1984
- 1984-05-17 IL IL71860A patent/IL71860A/xx unknown
- 1984-05-17 CA CA000454531A patent/CA1243028A/en not_active Expired
- 1984-05-17 FI FI841992A patent/FI81795C/fi not_active IP Right Cessation
- 1984-05-17 GR GR74757A patent/GR82015B/el unknown
- 1984-05-17 NZ NZ208186A patent/NZ208186A/en unknown
- 1984-05-17 ZA ZA843748A patent/ZA843748B/xx unknown
- 1984-05-17 DK DK248484A patent/DK248484A/da not_active Application Discontinuation
- 1984-05-17 MC MC841707A patent/MC1597A1/xx unknown
- 1984-05-18 HU HU841916A patent/HU192555B/hu not_active IP Right Cessation
- 1984-05-18 NO NO842003A patent/NO159271C/no unknown
- 1984-05-18 KR KR1019840002721A patent/KR840009102A/ko not_active Ceased
- 1984-05-18 ES ES532603A patent/ES8601141A1/es not_active Expired
- 1984-05-18 PT PT78618A patent/PT78618A/pt not_active IP Right Cessation
- 1984-05-18 AU AU28356/84A patent/AU570044B2/en not_active Ceased
- 1984-05-18 PH PH30693A patent/PH19670A/en unknown
- 1984-05-18 JP JP59098863A patent/JPS59222478A/ja active Pending
- 1984-05-21 AT AT84105777T patent/ATE32072T1/de not_active IP Right Cessation
- 1984-05-21 DE DE8484105777T patent/DE3468875D1/de not_active Expired
- 1984-05-21 EP EP84105777A patent/EP0126480B1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0126480A1 (de) | 1984-11-28 |
| GR82015B (enrdf_load_html_response) | 1984-12-12 |
| ATE32072T1 (de) | 1988-02-15 |
| AU2835684A (en) | 1984-11-22 |
| IL71860A0 (en) | 1984-09-30 |
| KR840009102A (ko) | 1984-12-24 |
| PT78618A (en) | 1984-06-01 |
| ES532603A0 (es) | 1985-11-01 |
| JPS59222478A (ja) | 1984-12-14 |
| CA1243028A (en) | 1988-10-11 |
| ZA843748B (en) | 1985-01-30 |
| US4544657A (en) | 1985-10-01 |
| HUT34185A (en) | 1985-02-28 |
| NZ208186A (en) | 1987-06-30 |
| PH19670A (en) | 1986-06-09 |
| HU192555B (en) | 1987-06-29 |
| NO842003L (no) | 1984-11-20 |
| IL71860A (en) | 1987-10-30 |
| EP0126480B1 (de) | 1988-01-20 |
| FI841992A0 (fi) | 1984-05-17 |
| NO159271B (no) | 1988-09-05 |
| AU570044B2 (en) | 1988-03-03 |
| DE3468875D1 (en) | 1988-02-25 |
| DK248484D0 (da) | 1984-05-17 |
| MC1597A1 (fr) | 1985-05-09 |
| FI841992A7 (fi) | 1984-11-20 |
| DK248484A (da) | 1984-11-20 |
| NO159271C (no) | 1988-12-14 |
| FI81795C (fi) | 1990-12-10 |
| FI81795B (fi) | 1990-08-31 |
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