ES8600301A1 - Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino-(5, 4-b)-1, 4-oxazina - Google Patents
Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino-(5, 4-b)-1, 4-oxazinaInfo
- Publication number
- ES8600301A1 ES8600301A1 ES529720A ES529720A ES8600301A1 ES 8600301 A1 ES8600301 A1 ES 8600301A1 ES 529720 A ES529720 A ES 529720A ES 529720 A ES529720 A ES 529720A ES 8600301 A1 ES8600301 A1 ES 8600301A1
- Authority
- ES
- Spain
- Prior art keywords
- benzoxepino
- oxazine
- oxazine derivatives
- acylating
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IHKALFITVBQHPG-UHFFFAOYSA-N 2h-[1]benzoxepino[5,4-b][1,4]oxazine Chemical class C1=COC2=CC=CC=C2C2=C1N=CCO2 IHKALFITVBQHPG-UHFFFAOYSA-N 0.000 title abstract 3
- -1 trans-(4a Chemical compound 0.000 abstract 2
- YRMMRFYPKHSIDT-PSASIEDQSA-N (4r,5r)-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol Chemical compound O[C@H]1[C@H](N)CCOC2=CC=CC=C21 YRMMRFYPKHSIDT-PSASIEDQSA-N 0.000 abstract 1
- XISPDFMAOWZEQG-UHFFFAOYSA-N 4h-1,4-oxazin-3-one Chemical compound O=C1COC=CN1 XISPDFMAOWZEQG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46640783A | 1983-02-15 | 1983-02-15 | |
| US56275983A | 1983-12-21 | 1983-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8600301A1 true ES8600301A1 (es) | 1985-10-01 |
| ES529720A0 ES529720A0 (es) | 1985-10-01 |
Family
ID=27041648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529720A Granted ES529720A0 (es) | 1983-02-15 | 1984-02-14 | Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino-(5, 4-b)-1, 4-oxazina |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0116373B1 (forum.php) |
| KR (1) | KR900005471B1 (forum.php) |
| AU (1) | AU561700B2 (forum.php) |
| CA (1) | CA1236833A (forum.php) |
| DE (1) | DE3463142D1 (forum.php) |
| DK (1) | DK158986C (forum.php) |
| ES (1) | ES529720A0 (forum.php) |
| GR (1) | GR81510B (forum.php) |
| IE (1) | IE56788B1 (forum.php) |
| IL (1) | IL70941A (forum.php) |
| NO (1) | NO167571C (forum.php) |
| NZ (1) | NZ207110A (forum.php) |
| PH (1) | PH22343A (forum.php) |
| PT (1) | PT78109B (forum.php) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE939614C (de) * | 1949-02-26 | 1956-02-23 | Ernst Rodenhaeuser | Kolbendichtung fuer Kolbenfuellhalter |
| PH21961A (en) * | 1983-02-15 | 1988-04-15 | Merrell Dow Pharma | 2h-(1)benzoxepino(5,4-b)-1,4-oxazine derivative |
| US4766212A (en) * | 1983-02-15 | 1988-08-23 | Merrell Dow Pharmaceuticals Inc. | 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives |
| FR2698873B1 (fr) * | 1992-12-07 | 1995-02-24 | Lipha | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| JP5952267B2 (ja) | 2010-05-21 | 2016-07-13 | リサーチ・トライアングル・インスティチュート | 薬物依存を処置するためのヒドロキシブプロピオン類似体（政府支援研究または開発） |
| ES2687095T3 (es) | 2010-05-21 | 2018-10-23 | Research Triangle Institute | Fenilimorfolinas y análogos de las mismas |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
-
1984
- 1984-02-10 NZ NZ207110A patent/NZ207110A/en unknown
- 1984-02-10 PH PH30228A patent/PH22343A/en unknown
- 1984-02-13 GR GR73786A patent/GR81510B/el unknown
- 1984-02-13 AU AU24542/84A patent/AU561700B2/en not_active Ceased
- 1984-02-13 IL IL70941A patent/IL70941A/xx not_active IP Right Cessation
- 1984-02-13 CA CA000447245A patent/CA1236833A/en not_active Expired
- 1984-02-14 IE IE334/84A patent/IE56788B1/en not_active IP Right Cessation
- 1984-02-14 NO NO840534A patent/NO167571C/no unknown
- 1984-02-14 ES ES529720A patent/ES529720A0/es active Granted
- 1984-02-14 DK DK066284A patent/DK158986C/da active
- 1984-02-14 EP EP84101520A patent/EP0116373B1/en not_active Expired
- 1984-02-14 KR KR1019840000692A patent/KR900005471B1/ko not_active Expired
- 1984-02-14 DE DE8484101520T patent/DE3463142D1/de not_active Expired
- 1984-02-15 PT PT78109A patent/PT78109B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1236833A (en) | 1988-05-17 |
| PT78109B (en) | 1986-05-20 |
| DK158986B (da) | 1990-08-13 |
| DK66284A (da) | 1984-08-16 |
| AU561700B2 (en) | 1987-05-14 |
| GR81510B (forum.php) | 1984-12-11 |
| DE3463142D1 (de) | 1987-05-21 |
| KR900005471B1 (ko) | 1990-07-30 |
| IE840334L (en) | 1984-08-15 |
| NO167571C (no) | 1991-11-20 |
| ES529720A0 (es) | 1985-10-01 |
| DK158986C (da) | 1991-01-07 |
| AU2454284A (en) | 1984-08-23 |
| IE56788B1 (en) | 1991-12-18 |
| PH22343A (en) | 1988-08-12 |
| IL70941A (en) | 1987-12-31 |
| EP0116373A1 (en) | 1984-08-22 |
| NO167571B (no) | 1991-08-12 |
| NZ207110A (en) | 1986-05-09 |
| DK66284D0 (da) | 1984-02-14 |
| IL70941A0 (en) | 1984-05-31 |
| NO840534L (no) | 1984-08-16 |
| KR840007729A (ko) | 1984-12-10 |
| EP0116373B1 (en) | 1987-04-15 |
| PT78109A (en) | 1984-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20040601 |