ES8602005A1 - Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino (5, 4-b)-1, 4-oxazina - Google Patents

Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino (5, 4-b)-1, 4-oxazina

Info

Publication number
ES8602005A1
ES8602005A1 ES529722A ES529722A ES8602005A1 ES 8602005 A1 ES8602005 A1 ES 8602005A1 ES 529722 A ES529722 A ES 529722A ES 529722 A ES529722 A ES 529722A ES 8602005 A1 ES8602005 A1 ES 8602005A1
Authority
ES
Spain
Prior art keywords
benzoxepino
oxazine
oxazine derivatives
acylating
resulting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529722A
Other languages
English (en)
Other versions
ES529722A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES8602005A1 publication Critical patent/ES8602005A1/es
Publication of ES529722A0 publication Critical patent/ES529722A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA (4A,11B)-3,4,4A,5,6,11B-HEXAHIDRO-2H-(1)BENZOXEPINO(5,4-B)-1,4-OXAZINA, DE FORMULA GENERAL (I), EN LA QUE R Y R1 SON HIDROGENO, FLUOR, CLORO O ALQUILO INFERIOR; Y R2 ES HIDROGENO O ALQUILO INFERIOR, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE REDUCE UNA 1,4-OXAZIN-3(4H)ONA, DE FORMULA GENERAL (II); SEGUNDA, SE HACE REACCIONAR LA (4A,11B)-3,4,4A,5,6,11B-HEXAHIDRO-2H-(1)-BENZOXEPINO(5,4-B)-1,4-OXAZINA CON UNCLORURO DE ACIDO O UN ANHIDRIDO DE ACIDO O CON UN HALOFORMIATO DE ALQUILO; Y POR ULTIMO, SE REDUCE QUIMICAMENTE EL COMPUESTO OBTENIDO EN LA REACCION ANTERIOR, DE FORMULA GENERAL (III). DE APLICACION POR SUS PROPIEDADES RELAJANTES DE LOS MUSCULOS Y ANALGESICAS, COMO MEDIO PARA ALIVIAR EL DOLOR EN ANIMALES DE SANGRE CALIENTE.
ES529722A 1983-02-15 1984-02-14 Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino (5, 4-b)-1, 4-oxazina Granted ES529722A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46644283A 1983-02-15 1983-02-15
US56275783A 1983-12-21 1983-12-21

Publications (2)

Publication Number Publication Date
ES8602005A1 true ES8602005A1 (es) 1985-11-01
ES529722A0 ES529722A0 (es) 1985-11-01

Family

ID=27041664

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529722A Granted ES529722A0 (es) 1983-02-15 1984-02-14 Un procedimiento para la preparacion de una (4a, 11b)-3, 4, 4a, 5, 6, 11b-hexahidro-2h-(1) benzoxepino (5, 4-b)-1, 4-oxazina

Country Status (14)

Country Link
EP (1) EP0116372B1 (es)
KR (1) KR900004147B1 (es)
AU (1) AU575553B2 (es)
CA (1) CA1236100A (es)
DE (1) DE3462138D1 (es)
DK (1) DK159116C (es)
ES (1) ES529722A0 (es)
GR (1) GR81512B (es)
IE (1) IE56787B1 (es)
IL (1) IL70942A (es)
NO (1) NO167030C (es)
NZ (1) NZ207111A (es)
PH (1) PH21961A (es)
PT (1) PT78107B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766212A (en) * 1983-02-15 1988-08-23 Merrell Dow Pharmaceuticals Inc. 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives
DE3831697A1 (de) * 1988-09-17 1990-03-22 Hoechst Ag 2,3,4,5-tetrahydro-1-benzoxepine, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593760A1 (de) * 1967-02-01 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer Benz-epinderivate
PH22343A (en) * 1983-02-15 1988-08-12 Merrell Dow Pharma 2h-(1) benzoxepino (5,4-b) 1,4-oxazine derivatives

Also Published As

Publication number Publication date
PH21961A (en) 1988-04-15
NO167030B (no) 1991-06-17
KR900004147B1 (ko) 1990-06-16
EP0116372A1 (en) 1984-08-22
IL70942A (en) 1987-12-31
IL70942A0 (en) 1984-05-31
DK66184D0 (da) 1984-02-14
NO840536L (no) 1984-08-16
DK159116B (da) 1990-09-03
IE840333L (en) 1984-08-15
IE56787B1 (en) 1991-12-18
PT78107B (en) 1986-05-20
PT78107A (en) 1984-03-01
EP0116372B1 (en) 1987-01-21
NO167030C (no) 1991-09-25
AU575553B2 (en) 1988-08-04
GR81512B (es) 1984-12-11
CA1236100A (en) 1988-05-03
NZ207111A (en) 1986-07-11
DK66184A (da) 1984-08-16
DK159116C (da) 1991-02-11
KR840007728A (ko) 1984-12-10
DE3462138D1 (de) 1987-02-26
ES529722A0 (es) 1985-11-01
AU2454084A (en) 1984-08-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519