ES8504929A1 - Un procedimiento para preparar una cepa modificada del virus de la diarrea virica de los bovinos - Google Patents

Un procedimiento para preparar una cepa modificada del virus de la diarrea virica de los bovinos

Info

Publication number
ES8504929A1
ES8504929A1 ES526380A ES526380A ES8504929A1 ES 8504929 A1 ES8504929 A1 ES 8504929A1 ES 526380 A ES526380 A ES 526380A ES 526380 A ES526380 A ES 526380A ES 8504929 A1 ES8504929 A1 ES 8504929A1
Authority
ES
Spain
Prior art keywords
virus
bvd
strains
preparation
vaccines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526380A
Other languages
English (en)
Other versions
ES526380A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline RIT
Original Assignee
SmithKline RIT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline RIT filed Critical SmithKline RIT
Publication of ES526380A0 publication Critical patent/ES526380A0/es
Publication of ES8504929A1 publication Critical patent/ES8504929A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation
    • C12N2770/24363—Methods of inactivation or attenuation by chemical treatment
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/813—Viral vaccine for bovine species, e.g. cattle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/821—Drug, bio-affecting and body treating compositions involving temperature-sensitive mutant virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UNA CEPA MODIFICADA DEL VIRUS DE LA DIARREA VIRICA DE LOS BOVINOS.CONSISTE EN PONER UNA CEPA DEL VIRUS DE LA DIARREA VIRICA DE LOS BOVINOS EN CONTACTO CON UN MUTAGENO QUIMICO TAL COMO ACIDO NITROSO A LA TEMPERATURA AMBIENTE EN CONDICIONES OPERATIVAS TALES QUE EL TITULO DE VIRUS INICIAL SE REDUCE EN UN FACTOR DE 2 A 3 LOG10 Y SE AISLA POR CULTIVO Y VALORACION A 35JC Y 39,5JC RESPECTIVAMENTE UN MUTANTE SENSIBLE A LA TEMPERATURA QUE PRESENTA UNA DIFERENCIA EN TITULOS DE APROXIMADAMENTE 3 LOG10 TCID50 ENTRE 35JC Y 39,5JC. LA CEPA DEL VIRUS SE PONE EN CONTACTO CON ACIDO NITROSO DURANTE 1 A 15 MINUTOS EN UNA SOLUCION ACUOSA TAMPONADA A UN PH COMPRENDIDO ENTRE 5 Y 6.
ES526380A 1982-10-13 1983-10-11 Un procedimiento para preparar una cepa modificada del virus de la diarrea virica de los bovinos Expired ES8504929A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/434,155 US4618493A (en) 1982-10-13 1982-10-13 Temperature sensitive strains of bovine viral diarrhoea virus, preparation thereof and vaccines containing them

Publications (2)

Publication Number Publication Date
ES526380A0 ES526380A0 (es) 1985-04-16
ES8504929A1 true ES8504929A1 (es) 1985-04-16

Family

ID=23723042

Family Applications (2)

Application Number Title Priority Date Filing Date
ES526380A Expired ES8504929A1 (es) 1982-10-13 1983-10-11 Un procedimiento para preparar una cepa modificada del virus de la diarrea virica de los bovinos
ES526382A Granted ES526382A0 (es) 1982-10-13 1983-10-11 Un procedimiento para preparar una vacuna contra la infeccion por el virus de la diarrea virica de los bovinos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526382A Granted ES526382A0 (es) 1982-10-13 1983-10-11 Un procedimiento para preparar una vacuna contra la infeccion por el virus de la diarrea virica de los bovinos

Country Status (16)

Country Link
US (1) US4618493A (es)
EP (1) EP0106831B1 (es)
JP (3) JPS5989631A (es)
AT (1) ATE48948T1 (es)
AU (1) AU572050B2 (es)
CA (1) CA1216234A (es)
DE (1) DE3381005D1 (es)
DK (1) DK170061B1 (es)
ES (2) ES8504929A1 (es)
FI (1) FI82264C (es)
GR (1) GR78966B (es)
IE (1) IE56438B1 (es)
NO (1) NO166953C (es)
NZ (1) NZ205491A (es)
PT (1) PT77454B (es)
ZA (1) ZA837573B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291228B1 (en) 1988-08-03 2001-09-18 Vericore Limited Vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3052606A (en) * 1958-08-30 1962-09-04 Behringwerke Ag Viral mutation with nitrites
US3293129A (en) * 1962-02-01 1966-12-20 Cornell Res Foundation Inc Immunization of cattle against virus diarrhea virus
US3629413A (en) * 1970-02-04 1971-12-21 Univ Southern Illinois Polyvalent bovine vaccines and methods of making and using same
US3907986A (en) * 1972-12-18 1975-09-23 Rit Rech Ind Therapeut Live attenuated infectious bovine rhinotracheitis virus vaccines and preparation thereof
GB1390467A (en) * 1973-03-30 1975-04-16 Rit Rech Ind Therapeut Vaccination method using temperature sensitive virus mutants
US3927208A (en) * 1973-05-14 1975-12-16 Rit Rech Ind Therapeut Live bovine adenovirus vaccines, preparation thereof and method of vaccination using them
US3962424A (en) * 1974-01-31 1976-06-08 Recherche Et Industrie Therapeutiques (R.I.T.) Live brovine adenovirus vaccines, preparation thereof and method of vaccination using them
US4053583A (en) * 1976-03-01 1977-10-11 Smithkline Corporation Live newcastle disease virus vaccines
JPS5817084B2 (ja) * 1978-08-25 1983-04-05 新明和工業株式会社 塵芥押込処理装置の操作装置

Also Published As

Publication number Publication date
GR78966B (es) 1984-10-02
FI833717A0 (fi) 1983-10-12
FI82264C (fi) 1991-02-11
DK472083D0 (da) 1983-10-13
IE56438B1 (en) 1991-07-31
ES8600058A1 (es) 1985-10-01
JPH05176764A (ja) 1993-07-20
FI833717A (fi) 1984-04-14
EP0106831A3 (en) 1986-01-22
ES526380A0 (es) 1985-04-16
DE3381005D1 (de) 1990-02-01
NZ205491A (en) 1989-07-27
ZA837573B (en) 1984-08-29
ES526382A0 (es) 1985-10-01
AU1852983A (en) 1984-04-19
AU572050B2 (en) 1988-04-28
PT77454A (en) 1983-11-01
JPH0773493B2 (ja) 1995-08-09
JPS5989631A (ja) 1984-05-23
EP0106831B1 (fr) 1989-12-27
DK170061B1 (da) 1995-05-15
IE832400L (en) 1984-04-13
NO833717L (no) 1984-04-16
NO166953C (no) 1991-09-18
JPH05192139A (ja) 1993-08-03
CA1216234A (en) 1987-01-06
US4618493A (en) 1986-10-21
DK472083A (da) 1984-04-14
PT77454B (en) 1986-02-26
FI82264B (fi) 1990-10-31
JPH0463862B2 (es) 1992-10-13
JPH0773494B2 (ja) 1995-08-09
ATE48948T1 (de) 1990-01-15
NO166953B (no) 1991-06-10
EP0106831A2 (fr) 1984-04-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040916