ES8504109A1 - Procedimiento de producir compuestos para el tratamiento de la hipertension - Google Patents
Procedimiento de producir compuestos para el tratamiento de la hipertensionInfo
- Publication number
- ES8504109A1 ES8504109A1 ES528816A ES528816A ES8504109A1 ES 8504109 A1 ES8504109 A1 ES 8504109A1 ES 528816 A ES528816 A ES 528816A ES 528816 A ES528816 A ES 528816A ES 8504109 A1 ES8504109 A1 ES 8504109A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- treating hypertension
- hypertension
- therefrom
- hydroxyamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 206010020772 Hypertension Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Stereophonic System (AREA)
- Indole Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
PROCEDIMIENTO PARA PRODUCIR COMPUESTOS PARA EL TRATAMIENTO DE LA HIPERTENSION.CONSISTE EN HACER REACCIONAR BAJO CONDICIONES DE FORMACION DE AMIDAS, UN COMPUESTO AMINO DE FORMULA (II) CON UN DERIVADO ACILANTE DE UN ACIDO DE FORMULA (III) E INTRODUCIR VARIOS SUSTITUYENTES EN LOS PRODUCTOS OBTENIDOS DE FORMULA (I), DONDE A Y A SON HIDROXI, ALCOXI Y OTROS; R1, R2, R4 Y R5 SON H, ALQUILO, ARILO Y OTROS; R3 ES H, ALQUILO INFERIOR Y OTROS; Y R6 ES H, ALQUILO, ALQUENILO, ALQUINILO Y OTROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/457,611 US4496541A (en) | 1983-01-12 | 1983-01-12 | Compounds for treating hypertension |
Publications (2)
Publication Number | Publication Date |
---|---|
ES528816A0 ES528816A0 (es) | 1985-05-01 |
ES8504109A1 true ES8504109A1 (es) | 1985-05-01 |
Family
ID=23817424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528816A Expired ES8504109A1 (es) | 1983-01-12 | 1984-01-12 | Procedimiento de producir compuestos para el tratamiento de la hipertension |
Country Status (16)
Country | Link |
---|---|
US (1) | US4496541A (es) |
EP (1) | EP0114067B1 (es) |
JP (1) | JPS59130844A (es) |
KR (1) | KR840007713A (es) |
AT (1) | ATE26841T1 (es) |
AU (1) | AU560330B2 (es) |
CA (1) | CA1257749A (es) |
DE (1) | DE3463385D1 (es) |
DK (1) | DK13484A (es) |
ES (1) | ES8504109A1 (es) |
FI (1) | FI85012C (es) |
IE (1) | IE56586B1 (es) |
IL (1) | IL70676A (es) |
NO (1) | NO840102L (es) |
NZ (1) | NZ206826A (es) |
ZA (1) | ZA84262B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4686295A (en) * | 1982-03-10 | 1987-08-11 | Usv Pharmaceutical Corporation | N-carboxy anhydride intermediates |
JPS6248696A (ja) * | 1985-08-27 | 1987-03-03 | Kanegafuchi Chem Ind Co Ltd | N−〔1(s)−エトキシカルボニル−3−フエニルプロピル〕−l−アラニル−l−プロリンの製造法 |
SI9200213A (en) * | 1992-09-16 | 1994-03-31 | Krka | Process for preparing alkyl-l-alanil-l-proline derivates |
US6262274B1 (en) * | 2000-10-13 | 2001-07-17 | Everlight Usa, Inc. | Process for preparing N-[1-(S)-ethyoxycarbonyl-3-phenylpropyl]-L-ananine N-carboxyanhydride |
FR2815962B1 (fr) * | 2000-10-30 | 2003-03-07 | Isochem Sa | Procede de preparation des n-carboxyanhydrides |
JP2008545006A (ja) * | 2005-07-05 | 2008-12-11 | シプラ・リミテッド | Ace阻害剤の合成方法 |
EA015450B1 (ru) | 2006-05-12 | 2011-08-30 | Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг | Фармацевтические промежуточные соединения в синтезе ингибиторов ацетилхолинэстеразы (асе) и их применение |
US7911232B2 (en) * | 2008-04-30 | 2011-03-22 | B & Plus K.K. | Input/output signal controller |
WO2010109590A1 (ja) * | 2009-03-24 | 2010-09-30 | 株式会社ビー・アンド・プラス | 入出力信号制御装置およびこれを用いた入出力信号制御システム |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1904M (fr) * | 1962-03-01 | 1963-07-08 | Merck & Co Inc | Médicament a base d'acide n-acyl-hydroxyamino-acétique pour le traitement des tumeurs. |
AT293358B (de) * | 1968-03-30 | 1971-10-11 | Richter Gedeon Vegyeszet | Verfahren zur Herstellung von neuen N-Acyl-hydroxylaminderivaten |
JPS4843726A (es) * | 1971-10-05 | 1973-06-23 | ||
US4098903A (en) * | 1976-06-01 | 1978-07-04 | Research Corporation | Anti-hypertensive compounds |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4820729A (en) * | 1981-03-30 | 1989-04-11 | Rorer Pharmaceutical Corporation | N-substituted-amido-amino acids |
-
1983
- 1983-01-12 US US06/457,611 patent/US4496541A/en not_active Expired - Fee Related
-
1984
- 1984-01-11 JP JP59002110A patent/JPS59130844A/ja active Pending
- 1984-01-12 ES ES528816A patent/ES8504109A1/es not_active Expired
- 1984-01-12 AT AT84100300T patent/ATE26841T1/de not_active IP Right Cessation
- 1984-01-12 NZ NZ206826A patent/NZ206826A/en unknown
- 1984-01-12 AU AU23254/84A patent/AU560330B2/en not_active Expired - Fee Related
- 1984-01-12 EP EP84100300A patent/EP0114067B1/en not_active Expired
- 1984-01-12 DK DK13484A patent/DK13484A/da not_active Application Discontinuation
- 1984-01-12 ZA ZA84262A patent/ZA84262B/xx unknown
- 1984-01-12 CA CA000445192A patent/CA1257749A/en not_active Expired
- 1984-01-12 FI FI840109A patent/FI85012C/fi not_active IP Right Cessation
- 1984-01-12 KR KR1019840000106A patent/KR840007713A/ko not_active Application Discontinuation
- 1984-01-12 NO NO840102A patent/NO840102L/no unknown
- 1984-01-12 IL IL70676A patent/IL70676A/xx not_active IP Right Cessation
- 1984-01-12 IE IE54/84A patent/IE56586B1/en not_active IP Right Cessation
- 1984-01-12 DE DE8484100300T patent/DE3463385D1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI840109A0 (fi) | 1984-01-12 |
ES528816A0 (es) | 1985-05-01 |
IE56586B1 (en) | 1991-10-09 |
FI840109A (fi) | 1984-07-13 |
DE3463385D1 (en) | 1987-06-04 |
AU560330B2 (en) | 1987-04-02 |
IL70676A (en) | 1988-09-30 |
ZA84262B (en) | 1984-08-29 |
DK13484D0 (da) | 1984-01-12 |
IE840054L (en) | 1984-07-12 |
NO840102L (no) | 1984-07-13 |
KR840007713A (ko) | 1984-12-10 |
AU2325484A (en) | 1984-07-19 |
FI85012B (fi) | 1991-11-15 |
IL70676A0 (en) | 1984-04-30 |
EP0114067A1 (en) | 1984-07-25 |
JPS59130844A (ja) | 1984-07-27 |
EP0114067B1 (en) | 1987-04-29 |
NZ206826A (en) | 1986-03-14 |
CA1257749A (en) | 1989-07-18 |
ATE26841T1 (de) | 1987-05-15 |
FI85012C (fi) | 1992-02-25 |
US4496541A (en) | 1985-01-29 |
DK13484A (da) | 1984-07-13 |
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