ES8405797A1 - Procedimiento de preparacion de nuevos derivados del azabiciclo (3.2.0) heptano. - Google Patents

Procedimiento de preparacion de nuevos derivados del azabiciclo (3.2.0) heptano.

Info

Publication number
ES8405797A1
ES8405797A1 ES518725A ES518725A ES8405797A1 ES 8405797 A1 ES8405797 A1 ES 8405797A1 ES 518725 A ES518725 A ES 518725A ES 518725 A ES518725 A ES 518725A ES 8405797 A1 ES8405797 A1 ES 8405797A1
Authority
ES
Spain
Prior art keywords
group
preparation
general formula
synthesis
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518725A
Other languages
English (en)
Other versions
ES518725A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES8405797A1 publication Critical patent/ES8405797A1/es
Publication of ES518725A0 publication Critical patent/ES518725A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL AZABICICLO (3.2.0) HEPTANO, DE FORMULA GENERAL (I), EN LA QUE Y E Y REPRESENTAN UN GRUPO PROTECTOR CARBONILO SEPARABLE, PREFERENTEMENTE UN GRUPO CETAL O UN TIOANALOGO DEL MISMO; Q ES UN GRUPO ALQUILO C1-5 O UN ATOMO DE HIDROGENO; Y R ES UN RESIDUO DE HIDROCARBURO DISCRECIONALMENTE SUSTITUIDO, PREFERIBLEMENTE UN GRUPO BENCILO.CONSISTE EN TRATAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE Y E Y TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Y Q ES UN GRUPO ALQUILO C1-5 O UN GRUPO BENCILO SUSTITUIDO, CON UN ADECUADO AGENTEO-ACILANTE, PREFERIBLEMENTE CON UN HALURO DE SULFONILO O DE FOSFORILO, Y LUEGO CON UN MERCAPTANO.DE APLICACION COMO PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE LA TIENAMICINA Y SUS ANALOGOS.
ES518725A 1981-12-30 1982-12-30 Procedimiento de preparacion de nuevos derivados del azabiciclo (3.2.0) heptano. Granted ES518725A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814017A HU185493B (en) 1981-12-30 1981-12-30 Process for producing new azabicyclo-bracket-3.2.0-bracket closedheptene derivatives

Publications (2)

Publication Number Publication Date
ES8405797A1 true ES8405797A1 (es) 1984-06-16
ES518725A0 ES518725A0 (es) 1984-06-16

Family

ID=10966528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518725A Granted ES518725A0 (es) 1981-12-30 1982-12-30 Procedimiento de preparacion de nuevos derivados del azabiciclo (3.2.0) heptano.

Country Status (18)

Country Link
JP (1) JPS58118588A (es)
AT (1) AT375944B (es)
AU (1) AU9197382A (es)
BE (1) BE895488A (es)
CA (1) CA1192202A (es)
DE (1) DE3248678A1 (es)
ES (1) ES518725A0 (es)
FI (1) FI824518L (es)
FR (1) FR2519002A1 (es)
GB (1) GB2112391B (es)
GR (1) GR78431B (es)
HU (1) HU185493B (es)
IT (1) IT1210971B (es)
LU (1) LU84564A1 (es)
NL (1) NL8205065A (es)
PL (1) PL239887A1 (es)
SE (1) SE8207480L (es)
ZA (1) ZA829600B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
JPS6028981A (ja) * 1983-07-27 1985-02-14 Shionogi & Co Ltd ジオキソラニルペネムカルボン酸誘導体
WO1999031106A1 (fr) * 1997-12-16 1999-06-24 Banyu Pharmaceutical Co., Ltd. Derives de carbapenem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use

Also Published As

Publication number Publication date
FR2519002A1 (fr) 1983-07-01
GB2112391B (en) 1985-10-16
LU84564A1 (fr) 1984-10-22
FI824518L (fi) 1983-07-01
FI824518A0 (fi) 1982-12-30
PL239887A1 (en) 1984-01-02
GB2112391A (en) 1983-07-20
IT1210971B (it) 1989-09-29
AU9197382A (en) 1983-07-07
GR78431B (es) 1984-09-27
JPS58118588A (ja) 1983-07-14
ZA829600B (en) 1983-10-26
ATA450982A (de) 1984-02-15
BE895488A (fr) 1983-06-28
IT8225065A0 (it) 1982-12-30
DE3248678A1 (de) 1983-07-07
AT375944B (de) 1984-09-25
HU185493B (en) 1985-02-28
NL8205065A (nl) 1983-07-18
SE8207480D0 (sv) 1982-12-29
SE8207480L (sv) 1983-07-01
ES518725A0 (es) 1984-06-16
CA1192202A (en) 1985-08-20

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