ES8405014A1 - Un procedimiento para la preparacion de derivados de acido clavulanico. - Google Patents

Un procedimiento para la preparacion de derivados de acido clavulanico.

Info

Publication number
ES8405014A1
ES8405014A1 ES516333A ES516333A ES8405014A1 ES 8405014 A1 ES8405014 A1 ES 8405014A1 ES 516333 A ES516333 A ES 516333A ES 516333 A ES516333 A ES 516333A ES 8405014 A1 ES8405014 A1 ES 8405014A1
Authority
ES
Spain
Prior art keywords
derivatives
clavulanic acid
preparation
antibiotics
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516333A
Other languages
English (en)
Other versions
ES516333A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES516333A0 publication Critical patent/ES516333A0/es
Publication of ES8405014A1 publication Critical patent/ES8405014A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO CLAVULANICO, DE FORMULA GENERAL (I) O UNA SAL O UN ESTER DEL MISMO.CONSISTE EN HACER REACCIONAR UN ION AZIDA CON UN ESTER DE UN COMPUESTO DE FORMULA (II), EN LA QUE R ES HIDROGENO, CARBOXI ESTERIFICADO O SALIFICADO, AZIDO, ISOCIANATO, CIANO, NITRO, BROMO O CLORO; Y R ES UN ATOMO DE BROMO O DE CLORO. A CONTINUACION, SI SE DESEA, SE PUEDE CONVERTIR CUALQUIER GRUPO ESTER EN UN ACIDO CARBOXILICO O EN UNA SAL CARBOXILICA, O CUALQUIER ACIDO CARBOXILICO O UNA SAL CARBOXILICA EN UN ESTER HIDROLIZABLEIN VIVO.DE APLICACION COMO ANTIBIOTICOS Y COMO INHIBIDORES DE B-LACTAMASA.
ES516333A 1980-12-09 1982-10-07 Un procedimiento para la preparacion de derivados de acido clavulanico. Expired ES8405014A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8039447 1980-12-09
GB8118110 1981-06-12

Publications (2)

Publication Number Publication Date
ES516333A0 ES516333A0 (es) 1984-05-16
ES8405014A1 true ES8405014A1 (es) 1984-05-16

Family

ID=26277788

Family Applications (4)

Application Number Title Priority Date Filing Date
ES507822A Expired ES8307251A1 (es) 1980-12-09 1981-12-09 Un procedimiento para la preparacion de derivados de acido clavulanico.
ES516333A Expired ES8405014A1 (es) 1980-12-09 1982-10-07 Un procedimiento para la preparacion de derivados de acido clavulanico.
ES516334A Granted ES516334A0 (es) 1980-12-09 1982-10-07 Un procedimiento para la preparacion de derivados de acido clavulanico.
ES520675A Expired ES8405016A1 (es) 1980-12-09 1983-03-16 Un procedimiento para la preparacion de una composicion de derivados del acido clavulanico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES507822A Expired ES8307251A1 (es) 1980-12-09 1981-12-09 Un procedimiento para la preparacion de derivados de acido clavulanico.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES516334A Granted ES516334A0 (es) 1980-12-09 1982-10-07 Un procedimiento para la preparacion de derivados de acido clavulanico.
ES520675A Expired ES8405016A1 (es) 1980-12-09 1983-03-16 Un procedimiento para la preparacion de una composicion de derivados del acido clavulanico.

Country Status (10)

Country Link
US (3) US4544549A (es)
EP (1) EP0053893B1 (es)
AU (1) AU7836681A (es)
CA (1) CA1175052A (es)
DE (1) DE3169452D1 (es)
ES (4) ES8307251A1 (es)
GR (1) GR76964B (es)
IE (1) IE52228B1 (es)
NZ (1) NZ199061A (es)
PT (1) PT74092B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303649D0 (en) * 1983-02-10 1983-03-16 Beecham Group Plc Beta-lactam compounds
GB9305837D0 (en) * 1993-03-20 1993-05-05 Smithkline Beecham Plc Novel compounds
SI1165049T2 (sl) * 1999-04-01 2011-11-30 Dsm Ip Assets Bv Aglomerati s kristalizacijo

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205682A1 (es) * 1970-06-11 1976-05-31 Philips Nv Metodo de produccion de ester (2-dimetilaminoetil) de acido (4-cloro-alfa - metilbenciliden) amino-oxiacetico y sus sales de adicion de acido formadas con acidos farmacologicamente aceptables
US4399142A (en) * 1973-05-03 1983-08-16 Smith Kline & French Laboratories Limited Pharmacologically active compounds
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
AU503489B2 (en) * 1975-10-13 1979-09-06 Beecham Group Limited Substituted aminodeoxy clavulanic acid
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
IL51267A (en) * 1976-01-31 1979-12-30 Beecham Group Ltd Clavulanic acid thioethers their preparation and pharmaceutical compositions containing them
GB1585124A (en) * 1976-06-04 1981-02-25 Glaxo Lab Ltd Clavulanic acid derivatives
BE858858A (fr) * 1976-10-16 1978-03-20 Fisons Ltd Composition de cromoglycate disodique
GB1599907A (en) * 1977-04-26 1981-10-07 Glaxo Lab Ltd Isoindolines
ZA785711B (en) * 1977-10-10 1979-09-26 Glaxo Group Ltd B-lactam compounds,process for their preparation,pharmaceutical compositions containing them and intermediates of use in their preparation
EP0007152A1 (en) * 1978-04-28 1980-01-23 Beecham Group Plc Beta-lactam antibiotics, preparation and use
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
EP0007753B1 (en) * 1978-08-02 1982-08-25 Beecham Group Plc Beta-lactam antibacterial agents, a process for their preparation and pharmaceutical compositions containing them
DE2966349D1 (en) * 1978-09-09 1983-12-01 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their use
US4405596A (en) * 1978-10-16 1983-09-20 Helbig Joachim W Pharmaceutical preparations for and treatment procedures involving increasing plasma bicarbonate level
DE2849646A1 (de) * 1978-11-16 1980-06-04 Hoechst Ag Thienylbenzoesaeurederivate und verfahren zu ihrer herstellung
AU538622B2 (en) * 1979-06-29 1984-08-23 Glaxo Group Limited 5-substituted thiophene carboxamides
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
ES8107211A1 (es) * 1979-08-09 1981-10-01 Glaxo Group Ltd Un procedimiento para la preparacion de nuevos derivados de benzoxocina.
US4402949A (en) * 1979-11-12 1983-09-06 Sandoz Ltd. Stable solutions of hydrogenated ergotalkaloids
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
IT1150955B (it) * 1980-06-06 1986-12-17 Lepetit Spa Derivati 3h-naft(1.2-d)-imidazolici il procedimento per la loro preparazione, il loro uso come agenti antiinfiammatori e le composizioni farmaceutiche che li contengono
EP0043197A1 (en) * 1980-07-02 1982-01-06 Beecham Group Plc Beta-Lactam antibiotic, its preparation and use
US4321254A (en) * 1980-09-26 1982-03-23 Smithkline Corporation Antiallergic imidodisulfamides
US4385047A (en) * 1981-01-05 1983-05-24 Smithkline Beckman Corporation Antiallergic imidodisulfamides
US4350685A (en) * 1981-02-06 1982-09-21 Smithkline Corporation Antiallergic imidodisulfamides
US4341786A (en) * 1981-03-02 1982-07-27 Smithkline Corporation Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds
FR2502153A1 (fr) * 1981-03-19 1982-09-24 Rech Pharmaceutiq Medicale Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant
US4401665A (en) * 1981-04-14 1983-08-30 Bristol-Myers Company Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use
US4402976A (en) * 1981-04-24 1983-09-06 E. R. Squibb & Sons, Inc. Method for treating glaucoma with systemic nadolol compositions
US4402974A (en) * 1981-06-23 1983-09-06 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
US4388316A (en) * 1981-10-02 1983-06-14 Eli Lilly And Company Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4397845A (en) * 1982-05-19 1983-08-09 The Upjohn Company Lincomycin 3-(5'-adenylate) as anesthetic

Also Published As

Publication number Publication date
PT74092B (en) 1983-05-23
ES520675A0 (es) 1984-05-16
ES8405015A1 (es) 1984-05-16
EP0053893A1 (en) 1982-06-16
ES516334A0 (es) 1984-05-16
CA1175052A (en) 1984-09-25
US4584291A (en) 1986-04-22
ES507822A0 (es) 1983-06-16
DE3169452D1 (en) 1985-04-25
PT74092A (en) 1982-01-01
AU7836681A (en) 1982-06-17
ES8307251A1 (es) 1983-06-16
IE52228B1 (en) 1987-08-19
GR76964B (es) 1984-09-04
ES8405016A1 (es) 1984-05-16
NZ199061A (en) 1984-10-19
EP0053893B1 (en) 1985-03-20
US4645671A (en) 1987-02-24
US4544549A (en) 1985-10-01
ES516333A0 (es) 1984-05-16
IE812881L (en) 1982-06-09

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