PT74092B - Process for the preparation of clavulanic acid derivatives and their use - Google Patents

Process for the preparation of clavulanic acid derivatives and their use

Info

Publication number
PT74092B
PT74092B PT74092A PT7409281A PT74092B PT 74092 B PT74092 B PT 74092B PT 74092 A PT74092 A PT 74092A PT 7409281 A PT7409281 A PT 7409281A PT 74092 B PT74092 B PT 74092B
Authority
PT
Portugal
Prior art keywords
preparation
acid derivatives
clavulanic acid
clavulanic
derivatives
Prior art date
Application number
PT74092A
Other languages
English (en)
Other versions
PT74092A (en
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of PT74092A publication Critical patent/PT74092A/pt
Publication of PT74092B publication Critical patent/PT74092B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT74092A 1980-12-09 1981-12-04 Process for the preparation of clavulanic acid derivatives and their use PT74092B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8039447 1980-12-09
GB8118110 1981-06-12

Publications (2)

Publication Number Publication Date
PT74092A PT74092A (en) 1982-01-01
PT74092B true PT74092B (en) 1983-05-23

Family

ID=26277788

Family Applications (1)

Application Number Title Priority Date Filing Date
PT74092A PT74092B (en) 1980-12-09 1981-12-04 Process for the preparation of clavulanic acid derivatives and their use

Country Status (10)

Country Link
US (3) US4544549A (pt)
EP (1) EP0053893B1 (pt)
AU (1) AU7836681A (pt)
CA (1) CA1175052A (pt)
DE (1) DE3169452D1 (pt)
ES (4) ES8307251A1 (pt)
GR (1) GR76964B (pt)
IE (1) IE52228B1 (pt)
NZ (1) NZ199061A (pt)
PT (1) PT74092B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8303649D0 (en) * 1983-02-10 1983-03-16 Beecham Group Plc Beta-lactam compounds
GB9305837D0 (en) * 1993-03-20 1993-05-05 Smithkline Beecham Plc Novel compounds
US6979735B1 (en) * 1999-04-01 2005-12-27 Dsm N.V. Agglomerates by crystallization

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205682A1 (es) * 1970-06-11 1976-05-31 Philips Nv Metodo de produccion de ester (2-dimetilaminoetil) de acido (4-cloro-alfa - metilbenciliden) amino-oxiacetico y sus sales de adicion de acido formadas con acidos farmacologicamente aceptables
US4399142A (en) * 1973-05-03 1983-08-16 Smith Kline & French Laboratories Limited Pharmacologically active compounds
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
AU503489B2 (en) * 1975-10-13 1979-09-06 Beecham Group Limited Substituted aminodeoxy clavulanic acid
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
IL51267A (en) * 1976-01-31 1979-12-30 Beecham Group Ltd Clavulanic acid thioethers their preparation and pharmaceutical compositions containing them
GB1585124A (en) * 1976-06-04 1981-02-25 Glaxo Lab Ltd Clavulanic acid derivatives
BE858858A (fr) * 1976-10-16 1978-03-20 Fisons Ltd Composition de cromoglycate disodique
GB1599907A (en) * 1977-04-26 1981-10-07 Glaxo Lab Ltd Isoindolines
JPS5473790A (en) * 1977-10-10 1979-06-13 Glaxo Group Ltd Betaalactam compound and manufacture
EP0007152A1 (en) * 1978-04-28 1980-01-23 Beecham Group Plc Beta-lactam antibiotics, preparation and use
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
DE2963580D1 (en) * 1978-08-02 1982-10-21 Beecham Group Plc Beta-lactam antibacterial agents, a process for their preparation and pharmaceutical compositions containing them
EP0008877B1 (en) * 1978-09-09 1983-10-26 Beecham Group Plc Derivatives of clavulanic acid, a process for their preparation and their use
US4405596A (en) * 1978-10-16 1983-09-20 Helbig Joachim W Pharmaceutical preparations for and treatment procedures involving increasing plasma bicarbonate level
DE2849646A1 (de) * 1978-11-16 1980-06-04 Hoechst Ag Thienylbenzoesaeurederivate und verfahren zu ihrer herstellung
ZA803879B (en) * 1979-06-29 1981-06-24 Glaxo Group Ltd Heterocyclic compounds, processes for their preparation and their use
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
DK344180A (da) * 1979-08-09 1981-02-10 Glaxo Group Ltd R fremgangsmaade til fremstilling af heterocycliske forbindelse
US4402949A (en) * 1979-11-12 1983-09-06 Sandoz Ltd. Stable solutions of hydrogenated ergotalkaloids
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
IT1150955B (it) * 1980-06-06 1986-12-17 Lepetit Spa Derivati 3h-naft(1.2-d)-imidazolici il procedimento per la loro preparazione, il loro uso come agenti antiinfiammatori e le composizioni farmaceutiche che li contengono
EP0043197A1 (en) * 1980-07-02 1982-01-06 Beecham Group Plc Beta-Lactam antibiotic, its preparation and use
US4321254A (en) * 1980-09-26 1982-03-23 Smithkline Corporation Antiallergic imidodisulfamides
US4385047A (en) * 1981-01-05 1983-05-24 Smithkline Beckman Corporation Antiallergic imidodisulfamides
US4350685A (en) * 1981-02-06 1982-09-21 Smithkline Corporation Antiallergic imidodisulfamides
US4341786A (en) * 1981-03-02 1982-07-27 Smithkline Corporation Pharmaceutical compositions and method of producing central alpha1 agonist activity utilizing octahydrobenzo[f]quinoline compounds
FR2502153A1 (fr) * 1981-03-19 1982-09-24 Rech Pharmaceutiq Medicale Acides (2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio) acetiques, leurs sels et leurs esters, leur procede de preparation et les compositions pharmaceutiques en contenant
US4401665A (en) * 1981-04-14 1983-08-30 Bristol-Myers Company Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use
US4402976A (en) * 1981-04-24 1983-09-06 E. R. Squibb & Sons, Inc. Method for treating glaucoma with systemic nadolol compositions
US4402974A (en) * 1981-06-23 1983-09-06 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4352809A (en) * 1981-09-04 1982-10-05 Smithkline Corporation Method of producing alpha2 antagonism
US4406898A (en) * 1981-09-08 1983-09-27 Eli Lilly And Company Oxazole and oxadiazole cephalosporins
US4396619A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin betaines
US4382932A (en) * 1981-09-08 1983-05-10 Eli Lilly And Company Isoquinolinium substituted cephalosporins
US4396620A (en) * 1981-09-08 1983-08-02 Eli Lilly And Company Cephalosporin quinolinium betaines
US4402955A (en) * 1981-10-02 1983-09-06 Eli Lilly And Company Dioximino cephalosporin antibiotics
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4388316A (en) * 1981-10-02 1983-06-14 Eli Lilly And Company Amino-substituted oxazole, oxadiazole and isoxazole-substituted cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4397845A (en) * 1982-05-19 1983-08-09 The Upjohn Company Lincomycin 3-(5'-adenylate) as anesthetic

Also Published As

Publication number Publication date
NZ199061A (en) 1984-10-19
ES516334A0 (es) 1984-05-16
DE3169452D1 (en) 1985-04-25
PT74092A (en) 1982-01-01
ES8405014A1 (es) 1984-05-16
EP0053893A1 (en) 1982-06-16
EP0053893B1 (en) 1985-03-20
ES8405015A1 (es) 1984-05-16
US4544549A (en) 1985-10-01
ES507822A0 (es) 1983-06-16
US4645671A (en) 1987-02-24
AU7836681A (en) 1982-06-17
US4584291A (en) 1986-04-22
IE52228B1 (en) 1987-08-19
CA1175052A (en) 1984-09-25
ES8405016A1 (es) 1984-05-16
ES8307251A1 (es) 1983-06-16
GR76964B (pt) 1984-09-04
ES520675A0 (es) 1984-05-16
ES516333A0 (es) 1984-05-16
IE812881L (en) 1982-06-09

Similar Documents

Publication Publication Date Title
IL60906A0 (en) -carbolin-3-carboxylic acid derivatives and methods of preparing the same
PH15907A (en) Novel naphthyridine derivatives and method of use thereof
DE3362277D1 (en) Penicillin derivatives and process for preparation of the same
PH16994A (en) Cephalosporin derivatives and its process of preparation
DE3163926D1 (en) Process for the preparation of anthraquinone and its substituted derivatives
GB2074563B (en) 2-penem-3-carboxylic acid derivatives their preparation and use
PT73061B (en) Process for the preparation of new derivatives of taurina and its pharmaceutical use
GB2058063B (en) Process for the preparation of 2-mercaptoalkyl-sulphides and 2-mercaptoalkylethers
DE3376979D1 (en) 3-methylflavone-8-carboxylic acid derivatives and process for the preparation of the same
GB2078220B (en) Penem-3-carboxylic acid derivatives and their preparation
ZA825876B (en) Novel cyclophoshamide derivatives process for their preparation and their use
GB2144418B (en) Thiazolinoazetidinone derivatives and process for the preparation of the same
IL61179A (en) 2-amino-4-substituted-5-thiazole-carboxylic acid derivatives and process for their preparation
DE3369850D1 (en) Penicillin derivatives and process for preparation of the same
DE3067890D1 (en) Maleimides and process for the preparation of same
DE3067697D1 (en) 1-azolyl-1-halogen-alkan-2-ones and process for the preparation of 1-azolyl-1-phenoxy-alkan-2-ones
PT74092A (en) Process for the preparation of clavulanic acid derivatives and their use
ZA805383B (en) -carbolin-3-carboxylic acid derivatives and methods of preparing the same
DE3165269D1 (en) Process for the preparation of penicillins and penicillin derivatives
DE3162049D1 (en) Method for the preparation of 2-halo-3-sulfonyl-acrylonitriles and their use
CS221993B2 (en) Method of preparation of the derivatives of the 15-acetoxy-9-oxoprostadien acid
ZA822030B (en) Process for the preparation of substituted alpha-halogenopropionic acids and their derivatives
ZA793640B (en) Process for the preparation of derivatives of clavulanic acid
PT73513B (en) Clavulanic acid derivatives their preparation and use
DE3062347D1 (en) Process for the preparation of derivatives of clavulanic acid