ES8403902A1 - Procedimiento de preparacion de derivados de aminodeso- xi-1.4; 3.6-dianhidro-hexito,asi como sus sales de adicion acida - Google Patents

Procedimiento de preparacion de derivados de aminodeso- xi-1.4; 3.6-dianhidro-hexito,asi como sus sales de adicion acida

Info

Publication number
ES8403902A1
ES8403902A1 ES503997A ES503997A ES8403902A1 ES 8403902 A1 ES8403902 A1 ES 8403902A1 ES 503997 A ES503997 A ES 503997A ES 503997 A ES503997 A ES 503997A ES 8403902 A1 ES8403902 A1 ES 8403902A1
Authority
ES
Spain
Prior art keywords
radical
signifies
omega
atoms
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503997A
Other languages
English (en)
Other versions
ES503997A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Willmar Schwabe GmbH and Co KG
Original Assignee
Dr Willmar Schwabe GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Willmar Schwabe GmbH and Co KG filed Critical Dr Willmar Schwabe GmbH and Co KG
Publication of ES8403902A1 publication Critical patent/ES8403902A1/es
Publication of ES503997A0 publication Critical patent/ES503997A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AMINO-DESOXI-1.4 3.6-DIANHIDRO-HEXITO, DE FORMULA GENERAL (I), EN LA QUE R1 Y R2 SIGNIFICAN UNO INDEPENDIENTEMENTE DEL OTRO, UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR CON 1 A 4 ATOMOS DE CARBONO; Y R3 SIGNIFICA UN ATOMO DE HIDROGENO O UN GRUPO METILSULFONILO, Y SUS SALES DE ADICION ACIDA.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, UN ISOHEXITO SE ESTERIFICA CON AYUDA DE UN CLORURO DE ACIDO SULFONICO, PARA FORMAR UN O-ACIL-ISO-HEXITO QUE CONTIENE UN GRUPO ACILO; SEGUNDA, EL ISOHEXITO-ACILOSE HACE REACCIONAR MEDIANTE AMONOLISIS, CON UNA SOLUCION ACUOSA DE AMONIACO, PARA FORMAR ALQUILAMINO-DESOXI-1.4; 3.6-DIANHIDRO-HEXITO; Y POR ULTIMO, EL COMPUESTO OBTENIDO EN LA REACCION ANTERIOR SE HACE REACCIONAR CON UN HALOGENURO DE V-PURINIL-1-OXOALCANO.DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES CORONARIAS.
ES503997A 1980-07-25 1981-07-15 Procedimiento de preparacion de derivados de aminodeso- xi-1.4; 3.6-dianhidro-hexito,asi como sus sales de adicion acida Granted ES503997A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803028288 DE3028288A1 (de) 1980-07-25 1980-07-25 Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung

Publications (2)

Publication Number Publication Date
ES8403902A1 true ES8403902A1 (es) 1984-04-16
ES503997A0 ES503997A0 (es) 1984-04-16

Family

ID=6108128

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503997A Granted ES503997A0 (es) 1980-07-25 1981-07-15 Procedimiento de preparacion de derivados de aminodeso- xi-1.4; 3.6-dianhidro-hexito,asi como sus sales de adicion acida

Country Status (7)

Country Link
US (2) US4413122A (es)
EP (1) EP0044932B1 (es)
JP (1) JPS5764696A (es)
AT (1) ATE12499T1 (es)
CA (1) CA1248096A (es)
DE (1) DE3028288A1 (es)
ES (1) ES503997A0 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028272A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung
DE3421072A1 (de) * 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA2014520C (en) * 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
ATE176668T1 (de) * 1993-07-23 1999-02-15 Merrell Pharma Inc Neue 9-n-bicyclische nucleosidverbindungen nützlich als selektive inhibitoren von proinflammatorische cytokinen
US6994310B2 (en) * 2003-04-24 2006-02-07 Ranco Incorporated Of Delaware Stepper motor driven valve for thermal management and associated method of use
DE102009000592A1 (de) 2009-02-04 2010-08-05 Evonik Degussa Gmbh Verfahren zur Herstellung von Aminogruppen tragenden, multizyklischen Ringsystemen
KR102638391B1 (ko) 2023-05-30 2024-02-20 삼화페인트공업주식회사 다이알칸설포닐 아이소소바이드 화합물의 제조 방법, 리튬이차전지용 전해액 첨가제, 리튬이차전지용 전해액 및 리튬이차전지

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545635A1 (de) * 1965-10-16 1969-08-07 Boehringer Mannheim Gmbh Verfahren zur Herstellung von Adenosin-Derivaten
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
GB1356374A (en) * 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
DE3028273A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate

Also Published As

Publication number Publication date
JPS637550B2 (es) 1988-02-17
EP0044932B1 (de) 1985-04-03
DE3028288A1 (de) 1982-02-25
CA1248096A (en) 1989-01-03
US4535158A (en) 1985-08-13
EP0044932A1 (de) 1982-02-03
ES503997A0 (es) 1984-04-16
DE3028288C2 (es) 1991-10-10
JPS5764696A (en) 1982-04-19
ATE12499T1 (de) 1985-04-15
US4413122A (en) 1983-11-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203