ES8402838A1 - Procedimiento para la obtencion de quinazolinonas triciclicas. - Google Patents
Procedimiento para la obtencion de quinazolinonas triciclicas.Info
- Publication number
- ES8402838A1 ES8402838A1 ES515693A ES515693A ES8402838A1 ES 8402838 A1 ES8402838 A1 ES 8402838A1 ES 515693 A ES515693 A ES 515693A ES 515693 A ES515693 A ES 515693A ES 8402838 A1 ES8402838 A1 ES 8402838A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- halogen
- trifluoromethyl
- represent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 150000002431 hydrogen Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 239000003204 tranquilizing agent Substances 0.000 abstract 2
- 230000002936 tranquilizing effect Effects 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE QUINAZOLINONAS TRICICLICAS, DE FORMULA GENERAL (I).CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R2, R3, R4, R5, R6 Y N TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Y M REPRESENTA UN METAL ALCALINO, CON UN COMPUESTO DE FORMULA (III), EN LA QUE R1 TIENE EL SIGNIFICADO YA INDICADO; Y X REPRESENTA HALOGENO.DE APLICACION COMO AGENTES TRANQUILIZANTES MENORES, EN PARTICULAR PARA ATENUAR LA ANGUSTIA O LA TENSION.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30248681A | 1981-09-16 | 1981-09-16 | |
US30248381A | 1981-09-16 | 1981-09-16 | |
US30248581A | 1981-09-16 | 1981-09-16 | |
US30248481A | 1981-09-16 | 1981-09-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8402838A1 true ES8402838A1 (es) | 1984-03-01 |
ES515693A0 ES515693A0 (es) | 1984-03-01 |
Family
ID=27501816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES515693A Granted ES515693A0 (es) | 1981-09-16 | 1982-09-14 | Procedimiento para la obtencion de quinazolinonas triciclicas. |
Country Status (12)
Country | Link |
---|---|
AU (1) | AU8838582A (es) |
DE (1) | DE3233766A1 (es) |
DK (1) | DK410782A (es) |
ES (1) | ES515693A0 (es) |
FI (1) | FI823207L (es) |
FR (1) | FR2512674B1 (es) |
GB (1) | GB2105721B (es) |
IT (1) | IT1189355B (es) |
NL (1) | NL8203587A (es) |
NZ (1) | NZ201915A (es) |
PT (1) | PT75555B (es) |
SE (1) | SE8205256L (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
US4760065A (en) * | 1986-02-13 | 1988-07-26 | Hardtmann Goetz E | Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity |
CZ281628B6 (cs) * | 1991-07-29 | 1996-11-13 | Warner-Lambert Company | Deriváty chinazolinu a farmaceutické přípravky na jejich bázi |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3631046A (en) * | 1969-05-28 | 1971-12-28 | Sandoz Ag | Tetracyclic quinazolin-ones |
-
1982
- 1982-09-10 FR FR8215474A patent/FR2512674B1/fr not_active Expired
- 1982-09-11 DE DE19823233766 patent/DE3233766A1/de not_active Withdrawn
- 1982-09-13 GB GB08226008A patent/GB2105721B/en not_active Expired
- 1982-09-14 SE SE8205256A patent/SE8205256L/xx not_active Application Discontinuation
- 1982-09-14 DK DK410782A patent/DK410782A/da not_active Application Discontinuation
- 1982-09-14 ES ES515693A patent/ES515693A0/es active Granted
- 1982-09-14 PT PT75555A patent/PT75555B/pt unknown
- 1982-09-14 AU AU88385/82A patent/AU8838582A/en not_active Abandoned
- 1982-09-14 NZ NZ201915A patent/NZ201915A/xx unknown
- 1982-09-15 IT IT49124/82A patent/IT1189355B/it active
- 1982-09-16 NL NL8203587A patent/NL8203587A/nl not_active Application Discontinuation
- 1982-09-16 FI FI823207A patent/FI823207L/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FR2512674B1 (fr) | 1986-01-10 |
SE8205256L (sv) | 1983-03-17 |
GB2105721A (en) | 1983-03-30 |
FI823207A0 (fi) | 1982-09-16 |
IT8249124A0 (it) | 1982-09-15 |
GB2105721B (en) | 1985-11-13 |
PT75555A (en) | 1982-10-01 |
ES515693A0 (es) | 1984-03-01 |
FI823207L (fi) | 1983-03-17 |
IT1189355B (it) | 1988-02-04 |
SE8205256D0 (sv) | 1982-09-14 |
NZ201915A (en) | 1985-11-08 |
NL8203587A (nl) | 1983-04-18 |
DK410782A (da) | 1983-03-17 |
FR2512674A1 (fr) | 1983-03-18 |
AU8838582A (en) | 1983-03-24 |
PT75555B (en) | 1985-05-31 |
DE3233766A1 (de) | 1983-03-31 |
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