ES8402826A1 - Procedimiento para la preparacion de una alcanoilimidazol-2-ona. - Google Patents

Procedimiento para la preparacion de una alcanoilimidazol-2-ona.

Info

Publication number
ES8402826A1
ES8402826A1 ES517041A ES517041A ES8402826A1 ES 8402826 A1 ES8402826 A1 ES 8402826A1 ES 517041 A ES517041 A ES 517041A ES 517041 A ES517041 A ES 517041A ES 8402826 A1 ES8402826 A1 ES 8402826A1
Authority
ES
Spain
Prior art keywords
alkanoylimidazol
derivatives
novel substituted
hydrogen
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517041A
Other languages
English (en)
Other versions
ES517041A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of ES8402826A1 publication Critical patent/ES8402826A1/es
Publication of ES517041A0 publication Critical patent/ES517041A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Fats And Perfumes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Chemical Treatment Of Metals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA ALCANOILIMIDAZOL-2-ONA, DE FORMULA GENERAL (I), EN LA QUE Q Y T SON CADA UNO DE ELLOS UN ATOMO DE OXIGENO; R ES HIDROGENO; R1 ES HIDROGENO O ALQUILO INFERIOR; Y R2 ES UN RADICAL DE HIDROCARBURO ALIFATICO INFERIOR, UN FENIL ALQUILENO O UN HETEROCICLO ALQUILENO.CONSISTE EN HACER REACCIONAR UNA AMINODICETONA, DE FORMULA GENERAL (II) EN LA QUE R1 Y R2 TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Y RK ES HIDROGENO, CON UNA SAL DE CIANATO.DE APLICACION COMO CARDIOTONICO EN EL TRATAMIENTO DE FALLOS CARDICOS.
ES517041A 1981-11-04 1982-11-02 Procedimiento para la preparacion de una alcanoilimidazol-2-ona. Granted ES517041A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/317,962 US4367236A (en) 1981-11-04 1981-11-04 Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives

Publications (2)

Publication Number Publication Date
ES8402826A1 true ES8402826A1 (es) 1984-03-01
ES517041A0 ES517041A0 (es) 1984-03-01

Family

ID=23236015

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517041A Granted ES517041A0 (es) 1981-11-04 1982-11-02 Procedimiento para la preparacion de una alcanoilimidazol-2-ona.

Country Status (17)

Country Link
US (1) US4367236A (es)
EP (1) EP0079049B1 (es)
JP (1) JPS5885867A (es)
KR (1) KR890001152B1 (es)
AT (1) ATE26264T1 (es)
AU (1) AU555244B2 (es)
CA (1) CA1227487A (es)
DE (1) DE3275922D1 (es)
DK (1) DK161251C (es)
ES (1) ES517041A0 (es)
GB (1) GB2112383B (es)
GR (1) GR77053B (es)
IE (1) IE54279B1 (es)
NO (1) NO156567C (es)
NZ (1) NZ202349A (es)
PH (1) PH22079A (es)
ZA (1) ZA827973B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556665A (en) * 1984-07-09 1985-12-03 Schering A.G. Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
US4868197A (en) * 1987-03-20 1989-09-19 Merrell Dow Pharmaceuticals Inc. Reducing reperfusion injury with 1,3-dihydro-4-methyl-5-(4-methylthio)benzoyl)-2H-imidazol-2-thione
WO1994021658A1 (en) * 1993-03-15 1994-09-29 Kalman Thomas I Antiviral imidazolinone nucleoside derivatives
CA2375287A1 (en) * 1999-06-22 2000-12-28 Takeda Chemical Industries, Ltd. Production method of imidazole derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441933A (en) * 1945-07-30 1948-05-18 Hoffmann La Roche Substituted imidazolones and process of making them
US2441935A (en) * 1946-03-14 1948-05-18 Hoffmann La Roche Imidazolidones and method for their manufacture
US2514380A (en) * 1946-12-26 1950-07-11 Hoffmann La Roche Diamines and method of production
US3303199A (en) * 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
GB1054708A (es) * 1964-10-02
JPS5049279A (es) * 1973-09-04 1975-05-01
JPS5088086A (es) * 1973-12-07 1975-07-15
JPS545447A (en) * 1977-06-14 1979-01-16 Fuji Photo Film Co Ltd Recording material
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones
US4405628A (en) * 1981-03-05 1983-09-20 Merrell Dow Pharmaceuticals Inc. 4-Pyridylimidazolones and method of use

Also Published As

Publication number Publication date
US4367236A (en) 1983-01-04
JPS5885867A (ja) 1983-05-23
KR840002361A (ko) 1984-06-25
PH22079A (en) 1988-05-20
NO156567B (no) 1987-07-06
EP0079049A2 (en) 1983-05-18
GB2112383B (en) 1985-07-17
KR890001152B1 (ko) 1989-04-25
DE3275922D1 (de) 1987-05-07
GB2112383A (en) 1983-07-20
ES517041A0 (es) 1984-03-01
EP0079049A3 (en) 1983-06-22
NO823647L (no) 1983-05-05
AU9011382A (en) 1983-05-12
DK488782A (da) 1983-05-05
ATE26264T1 (de) 1987-04-15
IE54279B1 (en) 1989-08-16
JPH0414111B2 (es) 1992-03-11
CA1227487A (en) 1987-09-29
NZ202349A (en) 1986-04-11
DK161251B (da) 1991-06-17
NO156567C (no) 1987-10-14
IE822620L (en) 1983-05-04
GR77053B (es) 1984-09-05
EP0079049B1 (en) 1987-04-01
DK161251C (da) 1991-12-02
ZA827973B (en) 1983-08-31
AU555244B2 (en) 1986-09-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303