ES8401526A1 - "un procedimiento para preparar un liposoma que contiene ubidecarenona". - Google Patents

"un procedimiento para preparar un liposoma que contiene ubidecarenona".

Info

Publication number
ES8401526A1
ES8401526A1 ES513789A ES513789A ES8401526A1 ES 8401526 A1 ES8401526 A1 ES 8401526A1 ES 513789 A ES513789 A ES 513789A ES 513789 A ES513789 A ES 513789A ES 8401526 A1 ES8401526 A1 ES 8401526A1
Authority
ES
Spain
Prior art keywords
ubidecarenone
pharmaceutical composition
liposomes
composition containing
containing liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513789A
Other languages
English (en)
Other versions
ES513789A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of ES8401526A1 publication Critical patent/ES8401526A1/es
Publication of ES513789A0 publication Critical patent/ES513789A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN LIPOSOMA QUE CONTIENE UBIDECARENONA. COMPRENDE LAS SIGUIENTES OPERACIONES: 1) CARGAR EN UN RECIPIENTE 1 MOL DE UBIDECARENONA Y UN COMPONENTE CONSTITUYENTE DE MEMBRANA DE LIPOSOMA, QUE SE COMPONE DE AL MENOS 10 MOLES DE UN FOSFOLIPIDO Y AL MENOS 1 MOL DE UN ESTEROL; EL FOSFOLIPIDO PUEDE SER FOSFATIDIL COLINA, FOSFATIDIL ESTANOLAMINA, FOSFATIDIL SERINA, ESFINGOMIELINA, ACIDO DICETILFOSFORICO, ESTEREARILAMINA, FOSFATIDIL GLICERINA, ACIDO FOSFATIDICO, FOSFATIDIL INOSITOL Y SUS MEZCLAS, Y COMO ESTEROL PUEDE SER EL COLESTEROL; 2) AÑADIR UN DISOLVENTE ORGANICO QUE PUEDE SER CLOROFORMO PARA DISOLVER ESTAS SUSTANCIAS; 3) EVAPORAR EL DISOLVENTE PARA FORMAR UNA MEMBRANA; 4) DESPRENDER LA MEMBRANA, AÑADIENDO UNA PERLA DE VIDRIO Y UN TAPON ADECUADO; 5) SOMETER LA DISOLUCION RESULTANTE A ULTRASONIDOS; 6) RECOGER LAS FRACCIONES DE LIPOSOMA SEPARANDO EL DISOLVENTE; LA SEPARACION DEL DISOLVENTE PUEDE EFECTUARSE POR LIOFILIZACION DURANTE AL MENOS 3 HORAS A UNA PRESION INFERIORA 2,0 TORR. ML DE APLICACION EN MEDICINA, PARA AUMENTAR LA TRANSFERENCIA DE UBIDECARENONA DE LA SANGRE A ORGANOS, TALES COMO EL CORAZON,EL BAZO Y EL HIGADO.
ES513789A 1981-07-08 1982-07-07 "un procedimiento para preparar un liposoma que contiene ubidecarenona". Granted ES513789A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56105689A JPS588010A (ja) 1981-07-08 1981-07-08 ユビデカレノン含有リポソ−ム

Publications (2)

Publication Number Publication Date
ES8401526A1 true ES8401526A1 (es) 1983-12-16
ES513789A0 ES513789A0 (es) 1983-12-16

Family

ID=14414361

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513789A Granted ES513789A0 (es) 1981-07-08 1982-07-07 "un procedimiento para preparar un liposoma que contiene ubidecarenona".

Country Status (7)

Country Link
EP (1) EP0069399B1 (es)
JP (1) JPS588010A (es)
KR (1) KR880002036B1 (es)
CA (1) CA1197463A (es)
DE (1) DE3273949D1 (es)
ES (1) ES513789A0 (es)
PH (1) PH17553A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01501153A (ja) * 1986-10-23 1989-04-20 アルバル・エッセ・ピ・ア ユビデカレノン類を含有する化粧品
IT1214540B (it) * 1986-10-23 1990-01-18 Vincenzo Zappia Mario De Rosa Formulazioni idrosolubili di ubidecarenoni, procedimento per laloro preparazione e composizioni farmaceutiche che li compongono.
US5690954A (en) * 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
US5298246A (en) * 1991-01-09 1994-03-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Stable pharmaceutical composition and method for its production
AU688033B2 (en) * 1994-07-06 1998-03-05 Colgate-Palmolive Company, The Aqueous liquid detergent compositions containing deflocculating polymers
JP2000502087A (ja) * 1995-12-15 2000-02-22 ナショナル リサーチ カウンシル オブ カナダ アジュバンドおよび送達賦形剤としての、アーケオソーム類、補酵素ｑ▲下１０▼を含有するアーケオソーム類、および補酵素ｑ▲下１０▼を含有する他の種類のリポソーム類
AU9221698A (en) * 1997-09-04 1999-03-22 Biozone Laboratories, Inc. Oral liposomal delivery system
JP3742602B2 (ja) * 2001-05-09 2006-02-08 株式会社カネカ 還元型補酵素ｑの安定な溶液
DE10255285A1 (de) * 2002-11-26 2004-06-03 Mcs Micro Carrier Systems Gmbh Selbst formende Phospholipid-Gele
CN1208052C (zh) * 2003-03-20 2005-06-29 上海家化联合股份有限公司 一种辅酶q10前体脂质体及其制备方法
JP2006137684A (ja) * 2004-11-10 2006-06-01 Nippon Fine Chem Co Ltd リポソーム前駆体の製造方法
JP5140913B2 (ja) * 2005-09-14 2013-02-13 日油株式会社 コエンザイムｑ１０含有化粧料用リポソーム
CA2977089A1 (en) * 2006-05-02 2007-11-15 University Of Miami Topical co-enzyme q10 formulations and treatment of pain, fatigue and wounds
EP2544663B1 (en) 2010-03-12 2018-01-03 Berg LLC Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
EP3634391A4 (en) 2017-05-17 2021-02-24 Berg LLC USE OF COENZYME Q10 FORMULATIONS IN THE TREATMENT AND PREVENTION OF BUBBLE EPIDERMOLYSIS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2249552A1 (de) * 1971-10-12 1973-05-30 Inchema S A Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen
JPS5919527B2 (ja) * 1976-01-13 1984-05-07 バテル メモリアル インステイチユ−ト リポソ−ムの製造方法
JPS5356315A (en) * 1976-11-01 1978-05-22 Eisai Co Ltd Emulsified solution of fat soluble drugs
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell
FR2472384A1 (fr) * 1979-12-27 1981-07-03 Sederma Sa Utilisation en cosmetologie de complexes naturels constitues d'ubiquinones et de phospholipides

Also Published As

Publication number Publication date
DE3273949D1 (en) 1986-12-04
ES513789A0 (es) 1983-12-16
CA1197463A (en) 1985-12-03
EP0069399A2 (en) 1983-01-12
JPH0321525B2 (es) 1991-03-22
PH17553A (en) 1984-09-20
JPS588010A (ja) 1983-01-18
KR840000241A (ko) 1984-02-18
EP0069399B1 (en) 1986-10-29
KR880002036B1 (ko) 1988-10-13
EP0069399A3 (en) 1983-03-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103