KR840000241A - 우비데카레논을 함유하는 리포솜 조성물 - Google Patents
우비데카레논을 함유하는 리포솜 조성물 Download PDFInfo
- Publication number
- KR840000241A KR840000241A KR1019820003038A KR820003038A KR840000241A KR 840000241 A KR840000241 A KR 840000241A KR 1019820003038 A KR1019820003038 A KR 1019820003038A KR 820003038 A KR820003038 A KR 820003038A KR 840000241 A KR840000241 A KR 840000241A
- Authority
- KR
- South Korea
- Prior art keywords
- phosphatidyl
- ubidecarenone
- composition according
- liposome
- liposome composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 8
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims 4
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims 4
- 229960004747 ubidecarenone Drugs 0.000 title claims 4
- 239000002502 liposome Substances 0.000 claims 7
- 229930182558 Sterol Natural products 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 150000003432 sterols Chemical class 0.000 claims 3
- 235000003702 sterols Nutrition 0.000 claims 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
- -1 smadmyelin Chemical compound 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 하기에서 술한 실시예 1에서 얻은 결과를 부여주는 그래프, 제2도-제3도는 하기에 서술한 실시예 2에서 얻은 결과를 보여주는 그래프.
Claims (6)
- 우비데카레논을 함유하는 리포솜 조성물.
- 리포솜 막에 우비데카레논이 존재하는 제1항에 따르는 리포솜 조성물.
- 리포솜 막이 인지질과 스테롤로 이루어진 제2항에 따르는 리포솜 조성물.
- 인지질을 포스파티딜 콜린, 포스파티딜 에타놀아민, 포스파리딜 세린, 스광고마이엘린, 디세틸포스포린산, 스테아릴아민, 포스파티딜 글리세롤, 포스파티딘산, 포스파티딜 이노시톨 그리고 그것의 혼합물에서 선택할 수 있는 제3항에 따르는 리포솜 조성물.
- 스테롤이콜레스테롤인 제3항 내지 제4항에 따르는 리포솜 조성물.
- 우비데카레논 1몰, 최소한 인지질 10몰 그리고 최소한 1몰의 스테롤을 함유하는 제3항 내지 제5항중의 어느 하나에 따른 리포솜 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP105.689 | 1981-07-08 | ||
| JP105689 | 1981-07-08 | ||
| JP56105689A JPS588010A (ja) | 1981-07-08 | 1981-07-08 | ユビデカレノン含有リポソ−ム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840000241A true KR840000241A (ko) | 1984-02-18 |
| KR880002036B1 KR880002036B1 (ko) | 1988-10-13 |
Family
ID=14414361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8203038A KR880002036B1 (ko) | 1981-07-08 | 1982-07-08 | 유비데카레논 함유 리포솜의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0069399B1 (ko) |
| JP (1) | JPS588010A (ko) |
| KR (1) | KR880002036B1 (ko) |
| CA (1) | CA1197463A (ko) |
| DE (1) | DE3273949D1 (ko) |
| ES (1) | ES513789A0 (ko) |
| PH (1) | PH17553A (ko) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1214540B (it) * | 1986-10-23 | 1990-01-18 | Vincenzo Zappia Mario De Rosa | Formulazioni idrosolubili di ubidecarenoni, procedimento per laloro preparazione e composizioni farmaceutiche che li compongono. |
| EP0287646B1 (en) * | 1986-10-23 | 1992-05-20 | Arval S.P.A. | Cosmetic preparations containing ubidecarenones |
| US5690954A (en) * | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
| GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| US5298246A (en) * | 1991-01-09 | 1994-03-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Stable pharmaceutical composition and method for its production |
| ZA955191B (en) * | 1994-07-06 | 1996-12-23 | Colgate Palmolive Co | Aqueous liquid detergent compositions containing deflocculating polymers |
| US6132789A (en) * | 1995-12-15 | 2000-10-17 | National Research Council Of Canada | Archaeosomes, archaeosomes containing coenzyme Q10, and other types of liposomes containing coenzyme Q10 as adjuvants and as delivery vehicles |
| EP1009383A1 (en) * | 1997-09-04 | 2000-06-21 | Biozone Laboratories, Inc. | Oral liposomal delivery system |
| JP3742602B2 (ja) * | 2001-05-09 | 2006-02-08 | 株式会社カネカ | 還元型補酵素ｑの安定な溶液 |
| DE10255285A1 (de) * | 2002-11-26 | 2004-06-03 | Mcs Micro Carrier Systems Gmbh | Selbst formende Phospholipid-Gele |
| CN1208052C (zh) * | 2003-03-20 | 2005-06-29 | 上海家化联合股份有限公司 | 一种辅酶q10前体脂质体及其制备方法 |
| JP2006137684A (ja) * | 2004-11-10 | 2006-06-01 | Nippon Fine Chem Co Ltd | リポソーム前駆体の製造方法 |
| JP5140913B2 (ja) * | 2005-09-14 | 2013-02-13 | 日油株式会社 | コエンザイムｑ１０含有化粧料用リポソーム |
| ES2836184T3 (es) * | 2006-05-02 | 2021-06-24 | Univ Miami | Formulaciones tópicas de co-enzima Q10 y tratamiento de heridas |
| CN102892412B (zh) | 2010-03-12 | 2015-09-30 | 博格制药有限责任公司 | 辅酶Q10(CoQ10)的静脉内制剂及其使用方法 |
| MA52274A (fr) | 2017-05-17 | 2021-02-24 | Berg Llc | Utilisation de formulations de coenzyme q10 dans le traitement et la prévention de l'épidermolyse bulleuse |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2249552A1 (de) * | 1971-10-12 | 1973-05-30 | Inchema S A | Verfahren zur inkapsulation von insbesondere wasserloeslichen verbindungen |
| JPS5919527B2 (ja) * | 1976-01-13 | 1984-05-07 | バテル メモリアル インステイチユ−ト | リポソ−ムの製造方法 |
| JPS5356315A (en) * | 1976-11-01 | 1978-05-22 | Eisai Co Ltd | Emulsified solution of fat soluble drugs |
| JPS55118415A (en) * | 1979-02-28 | 1980-09-11 | Pii Papahadojiyopo Dometoriosu | Method of encapsulating biologically active substance in lipoid cell |
| FR2472384A1 (fr) * | 1979-12-27 | 1981-07-03 | Sederma Sa | Utilisation en cosmetologie de complexes naturels constitues d'ubiquinones et de phospholipides |
-
1981
- 1981-07-08 JP JP56105689A patent/JPS588010A/ja active Granted
-
1982
- 1982-07-07 CA CA000406797A patent/CA1197463A/en not_active Expired
- 1982-07-07 ES ES513789A patent/ES513789A0/es active Granted
- 1982-07-08 DE DE8282106124T patent/DE3273949D1/de not_active Expired
- 1982-07-08 PH PH27536A patent/PH17553A/en unknown
- 1982-07-08 EP EP82106124A patent/EP0069399B1/en not_active Expired
- 1982-07-08 KR KR8203038A patent/KR880002036B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0321525B2 (ko) | 1991-03-22 |
| EP0069399A2 (en) | 1983-01-12 |
| EP0069399A3 (en) | 1983-03-30 |
| DE3273949D1 (en) | 1986-12-04 |
| PH17553A (en) | 1984-09-20 |
| JPS588010A (ja) | 1983-01-18 |
| EP0069399B1 (en) | 1986-10-29 |
| KR880002036B1 (ko) | 1988-10-13 |
| ES8401526A1 (es) | 1983-12-16 |
| CA1197463A (en) | 1985-12-03 |
| ES513789A0 (es) | 1983-12-16 |
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