ES8308561A1 - Procedimiento para la obtencion de nuevas piridazinonas. - Google Patents

Procedimiento para la obtencion de nuevas piridazinonas.

Info

Publication number
ES8308561A1
ES8308561A1 ES510055A ES510055A ES8308561A1 ES 8308561 A1 ES8308561 A1 ES 8308561A1 ES 510055 A ES510055 A ES 510055A ES 510055 A ES510055 A ES 510055A ES 8308561 A1 ES8308561 A1 ES 8308561A1
Authority
ES
Spain
Prior art keywords
compounds
pyridazinones
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510055A
Other languages
English (en)
Other versions
ES510055A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8308561A1 publication Critical patent/ES8308561A1/es
Publication of ES510055A0 publication Critical patent/ES510055A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Treating Waste Gases (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVAS PIRIDAZINONAS. CONSISTE EN HACER REACCIONAR UN ACIDO CETOCARBOXILICO (II) O UN DERIVADO REACTIVO DE ESTE, CON HIDRAZINA. SE OBTIENE EL COMPUESTO (I) DONDE R ES UN GRUPO AMINO, EL CUAL SE PUEDE TRANSFORMAR EN UN GRUPO ACETILAMINO Y/O EL COMPUESTO (I) EN QUE R ES HIDROXI SE TRANSFORMA EN UN COMPUESTO EN QUE R ES HALOGENO O UN GRUPO METOXI; CUANDO R ES AMINO DICHO COMPUESTO (I) SE PUEDE TRANSFORMAR EN LA SAL DE ADICION CORRESPONDIENTE.
ES510055A 1981-03-04 1982-03-02 Procedimiento para la obtencion de nuevas piridazinonas. Granted ES510055A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH144381 1981-03-04

Publications (2)

Publication Number Publication Date
ES8308561A1 true ES8308561A1 (es) 1983-09-16
ES510055A0 ES510055A0 (es) 1983-09-16

Family

ID=4210578

Family Applications (4)

Application Number Title Priority Date Filing Date
ES510055A Granted ES510055A0 (es) 1981-03-04 1982-03-02 Procedimiento para la obtencion de nuevas piridazinonas.
ES520022A Expired ES8403892A1 (es) 1981-03-04 1983-02-23 Procedimiento para la obtencion de nuevas piridazinonas.
ES520023A Expired ES8403893A1 (es) 1981-03-04 1983-02-23 Procedimiento para la obtencion de nuevas piridazinonas.
ES520024A Granted ES520024A0 (es) 1981-03-04 1983-02-23 Procedimiento para la obtencion de nuevas piridazinonas.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES520022A Expired ES8403892A1 (es) 1981-03-04 1983-02-23 Procedimiento para la obtencion de nuevas piridazinonas.
ES520023A Expired ES8403893A1 (es) 1981-03-04 1983-02-23 Procedimiento para la obtencion de nuevas piridazinonas.
ES520024A Granted ES520024A0 (es) 1981-03-04 1983-02-23 Procedimiento para la obtencion de nuevas piridazinonas.

Country Status (24)

Country Link
US (3) US4613599A (es)
EP (1) EP0059688B1 (es)
JP (1) JPS57158762A (es)
AT (1) ATE13294T1 (es)
AU (1) AU558039B2 (es)
CA (1) CA1180703A (es)
CY (1) CY1396A (es)
DD (1) DD209461A5 (es)
DE (1) DE3263497D1 (es)
DK (1) DK148772C (es)
ES (4) ES510055A0 (es)
FI (1) FI72718C (es)
GB (1) GB2094302B (es)
GR (1) GR81397B (es)
HK (1) HK87687A (es)
HU (1) HU191083B (es)
IE (1) IE52672B1 (es)
IL (1) IL65161A (es)
MY (1) MY8700736A (es)
NO (1) NO158135C (es)
NZ (1) NZ199892A (es)
PT (1) PT74520B (es)
SG (1) SG59587G (es)
ZA (1) ZA821397B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
GB8400863D0 (en) * 1984-01-13 1984-02-15 Smith Kline French Lab Chemical compounds
GB8426804D0 (en) * 1984-10-23 1984-11-28 Ciba Geigy Ag Pyridazinones preparations
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
IL79280A (en) * 1985-07-05 1990-07-12 Smith Kline French Lab 4-(6-oxo-dihydro or tetrahydropyridazin-3-yl)benzene derivatives,their preparation and pharmaceutical compositions containing them
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
DE3735207A1 (de) * 1987-10-17 1989-04-27 Basf Ag Mittel auf der basis von phenylpyridazinon-derivaten zur wachstumsfoerderung und fettreduktion bei tieren
US9890127B2 (en) * 2013-03-11 2018-02-13 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
EP3661917B1 (en) 2017-08-04 2022-05-11 Bayer Aktiengesellschaft 6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1488330A (en) * 1923-02-01 1924-03-25 Everitt James Clothes-hanging bar formed of hinged-together members
IL37788A0 (en) * 1970-10-09 1971-12-29 American Cyanamid Co New pyridazinone compounds,their preparation and pharmaceutical compositions containing them
GB1383906A (en) * 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
GB1488330A (en) * 1973-12-19 1977-10-12 Smith Kline French Lab Dihydropyridazinones
DE2854191A1 (de) * 1978-12-15 1980-07-03 Basf Ag Dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel

Also Published As

Publication number Publication date
DK148772C (da) 1986-05-12
IL65161A0 (en) 1982-05-31
GB2094302B (en) 1984-10-10
AU8106582A (en) 1982-09-09
ES8403894A1 (es) 1984-04-01
DK91782A (da) 1982-09-05
ES520022A0 (es) 1984-04-01
IE52672B1 (en) 1988-01-20
GB2094302A (en) 1982-09-15
FI820699L (fi) 1982-09-05
IL65161A (en) 1985-05-31
ES510055A0 (es) 1983-09-16
MY8700736A (en) 1987-12-31
CY1396A (en) 1987-12-18
AU558039B2 (en) 1987-01-15
ES520023A0 (es) 1984-04-01
NO158135C (no) 1988-07-20
GR81397B (es) 1984-12-11
HK87687A (en) 1987-12-04
ZA821397B (en) 1983-01-26
JPS57158762A (en) 1982-09-30
ATE13294T1 (de) 1985-06-15
DE3263497D1 (en) 1985-06-20
PT74520A (de) 1982-04-01
US4654340A (en) 1987-03-31
NZ199892A (en) 1985-05-31
US4613599A (en) 1986-09-23
PT74520B (de) 1984-11-19
US4704391A (en) 1987-11-03
NO820670L (no) 1982-09-06
FI72718C (fi) 1987-07-10
EP0059688A1 (de) 1982-09-08
ES8403892A1 (es) 1984-04-01
NO158135B (no) 1988-04-11
ES520024A0 (es) 1984-04-01
DK148772B (da) 1985-09-23
DD209461A5 (de) 1984-05-09
EP0059688B1 (de) 1985-05-15
SG59587G (en) 1987-10-23
FI72718B (fi) 1987-03-31
HU191083B (en) 1987-01-28
ES8403893A1 (es) 1984-04-01
CA1180703A (en) 1985-01-08
IE820478L (en) 1982-09-04

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