ES8306711A1 - "un procedimiento para preparar derivados de dimetil-propanamida". - Google Patents

"un procedimiento para preparar derivados de dimetil-propanamida".

Info

Publication number
ES8306711A1
ES8306711A1 ES512430A ES512430A ES8306711A1 ES 8306711 A1 ES8306711 A1 ES 8306711A1 ES 512430 A ES512430 A ES 512430A ES 512430 A ES512430 A ES 512430A ES 8306711 A1 ES8306711 A1 ES 8306711A1
Authority
ES
Spain
Prior art keywords
phenyl
propanamid
phenylethyl
dimethyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512430A
Other languages
English (en)
Other versions
ES512430A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES512430A0 publication Critical patent/ES512430A0/es
Publication of ES8306711A1 publication Critical patent/ES8306711A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE DIMETIL-PROPANAMIDA DE FORMULA GENERAL (I). SE HACE REACCIONAR UNA ORTO-TOLUIDINA ACILADA EN N DE FORMULA (II) CON UN N-ALCOHIL-LITIO EN SOLUCION EN DISOLVENTES ETEREOS E HIDROCARBONADOS INERTES, EN UNA ATMOSFERA SUSTANCIALMENTE ANHIDRA, A UNA TEMPERATURA COMPRENDIDA ENTRE -70 Y +30 C Y DURANTE DE 0,5 A 5 HORAS, DANDO UN COMPUESTO INTERMEDIO DILITIADO DE FORMULA (III). SE EXTINGUE ESTE COMPUESTO CON UNA N-BENCILIDEN-AMINA DE FORMULA (IV) A UNA TEMPERATURA COMPRENDIDA ENTRE -78 Y +35 C Y DURANTE DE 5 MINUTOS A UNA HORA, EN UNA ATMOSFERA SUSTANCIALMENTE ANHIDRA. SE UTILIZA COMO ANTIDEPRESIVO, ANALGESICO Y ANTICONVULSIVO.
ES512430A 1981-05-28 1982-05-21 "un procedimiento para preparar derivados de dimetil-propanamida". Expired ES8306711A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26799081A 1981-05-28 1981-05-28

Publications (2)

Publication Number Publication Date
ES512430A0 ES512430A0 (es) 1983-06-01
ES8306711A1 true ES8306711A1 (es) 1983-06-01

Family

ID=23020992

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512430A Expired ES8306711A1 (es) 1981-05-28 1982-05-21 "un procedimiento para preparar derivados de dimetil-propanamida".

Country Status (12)

Country Link
EP (1) EP0066773B1 (es)
JP (2) JPS57200342A (es)
KR (1) KR880002290B1 (es)
AT (1) ATE9219T1 (es)
CA (1) CA1182451A (es)
DE (1) DE3260654D1 (es)
DK (1) DK239582A (es)
ES (1) ES8306711A1 (es)
FI (1) FI821872A0 (es)
GR (1) GR76446B (es)
NO (1) NO821762L (es)
PT (1) PT74966B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES484553A1 (es) * 1978-10-05 1980-05-16 Hoechst Ag Un metodo para preparar 4-fenil-1,3-benzodiazepinas

Also Published As

Publication number Publication date
NO821762L (no) 1982-11-29
EP0066773A1 (en) 1982-12-15
ATE9219T1 (de) 1984-09-15
CA1182451A (en) 1985-02-12
ES512430A0 (es) 1983-06-01
JPH04217965A (ja) 1992-08-07
KR880002290B1 (ko) 1988-10-22
DE3260654D1 (en) 1984-10-11
JPH0352453B2 (es) 1991-08-12
GR76446B (es) 1984-08-10
PT74966A (en) 1982-06-01
EP0066773B1 (en) 1984-09-05
PT74966B (en) 1984-11-26
FI821872A0 (fi) 1982-05-26
DK239582A (da) 1982-11-29
JPS57200342A (en) 1982-12-08
KR830010050A (ko) 1983-12-24

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