ES8305724A1 - Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida. - Google Patents

Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida.

Info

Publication number
ES8305724A1
ES8305724A1 ES513980A ES513980A ES8305724A1 ES 8305724 A1 ES8305724 A1 ES 8305724A1 ES 513980 A ES513980 A ES 513980A ES 513980 A ES513980 A ES 513980A ES 8305724 A1 ES8305724 A1 ES 8305724A1
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
compositions containing
preparation
substituted acetamides
dimethylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513980A
Other languages
English (en)
Other versions
ES513980A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST INVESTIGAC Y DESARROLLO Q
Medichem SA
Original Assignee
INST INVESTIGAC Y DESARROLLO Q
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES513980A priority Critical patent/ES513980A0/es
Application filed by INST INVESTIGAC Y DESARROLLO Q, Medichem SA filed Critical INST INVESTIGAC Y DESARROLLO Q
Publication of ES8305724A1 publication Critical patent/ES8305724A1/es
Publication of ES513980A0 publication Critical patent/ES513980A0/es
Priority to SE8303862A priority patent/SE8303862L/xx
Priority to DE19833325004 priority patent/DE3325004A1/de
Priority to JP58126819A priority patent/JPS5951272A/ja
Priority to CA000432227A priority patent/CA1215048A/en
Priority to IT22053/83A priority patent/IT1169538B/it
Priority to FR8311715A priority patent/FR2530244B1/fr
Priority to BE6/47848A priority patent/BE897281A/fr
Priority to NL8302507A priority patent/NL8302507A/nl
Priority to GB08319108A priority patent/GB2124223B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LA 2-(HEXAHIDROACEPIN)-N-(2,6-DIMETIL FENIL)-ACETAMIDA, DE FORMULA (I). COMPRENDE LAS SIGUIENTES FASES: PRIMERA, SE HACE REACCIONAR EL COMPUESTO 2,6-DIMETIL-ANILINA CON CLORURO DE ACIDO CLOROACETICO PARA OBTENER CLOROAMIDA; SEGUNDA, SE HACE REACCIONAR LA CLOROAMIDA OBTENIDA EN LA FASE ANTERIOR CON HEXAHIDROAZEPINA PARA OBTENER LA 2-(HEXAHIDROACEPIN)-N-(2,6-DIMETILFENIL)-ACETAMIDA BUSCADA; Y POR ULTIMO, SE AISLA EL COMPUESTO OBTENIDO Y SE CRISTALIZA AL ENFRIARLO. DE APLICACION EN MEDICINA POR SU ACTIVIDAD ANESTESICA LOCAL Y POR SU ACTIVIDAD ANTI-ARRITMICA.
ES513980A 1982-07-14 1982-07-14 Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida. Granted ES513980A0 (es)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ES513980A ES513980A0 (es) 1982-07-14 1982-07-14 Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida.
SE8303862A SE8303862L (sv) 1982-07-14 1983-07-06 Ny forening 2-(hexahydroazepin)-n-(2,6-dimetylfenyl)acetamid, klorvetet av denna forening, forfarande for framstellning av foreningen samt farmaceutiska sammansettningar innehallande foreningarna
DE19833325004 DE3325004A1 (de) 1982-07-14 1983-07-11 2-(hexahydroazepino)-n-(2,6-dimethylphenyl)-acetamid und dessen hydrochlorid, verfahren zur herstellung dieser verbindungen und diese verbindungen enthaltende arzneimittel
JP58126819A JPS5951272A (ja) 1982-07-14 1983-07-11 ２−（ヘキサヒドロアゼピノ）−ｎ−（２，６−ジメチルフエニル）−アセトアミド、その製造法及びそれを含む医薬
CA000432227A CA1215048A (en) 1982-07-14 1983-07-12 2-(hexahydroazepino)-n-(2,6-dimethylphenyl)- acetamide, the hydrochloride thereof, a process for the preparation thereof and pharmaceutical compositions containing them
IT22053/83A IT1169538B (it) 1982-07-14 1983-07-13 2-(esaidroazepin)-n-(2,6-dimetilfenil))-acetammide,suo cloridrato,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
NL8302507A NL8302507A (nl) 1982-07-14 1983-07-13 2-(hexahydroazepino)-n-(2,6-dimethylfenyl)-aceetamide alsmede farmaceutische preparaten die deze verbinding bevatten.
BE6/47848A BE897281A (fr) 1982-07-14 1983-07-13 Le 2 (hexahydroazepine)-n-(2,6-dimethylphenyle)-acetamide son derive chlorhydrate, procede pour leur obtention et compositions pharmaceutique les contenant
FR8311715A FR2530244B1 (fr) 1982-07-14 1983-07-13 Le 2-(hexahydroazepine)-n-(2,6-dimethylphenyle)-acetamide, son derive chlorhydrate, procede pour leur obtention et compositions pharmaceutiques les contenant
GB08319108A GB2124223B (en) 1982-07-14 1983-07-14 Substituted acetamides a process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES513980A ES513980A0 (es) 1982-07-14 1982-07-14 Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida.

Publications (2)

Publication Number Publication Date
ES8305724A1 true ES8305724A1 (es) 1983-04-16
ES513980A0 ES513980A0 (es) 1983-04-16

Family

ID=8484458

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513980A Granted ES513980A0 (es) 1982-07-14 1982-07-14 Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida.

Country Status (10)

Country Link
JP (1) JPS5951272A (es)
BE (1) BE897281A (es)
CA (1) CA1215048A (es)
DE (1) DE3325004A1 (es)
ES (1) ES513980A0 (es)
FR (1) FR2530244B1 (es)
GB (1) GB2124223B (es)
IT (1) IT1169538B (es)
NL (1) NL8302507A (es)
SE (1) SE8303862L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8900685D0 (sv) * 1989-02-28 1989-02-28 Astra Ab New compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR907128A (fr) * 1943-07-15 1946-03-01 Astra Ab Procédé de préparation de produits d'anesthésie locale
DE963427C (de) * 1952-12-17 1957-05-09 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung neuer anaesthetisch wirkender Aminocarbonsaeureamide
HU183721B (en) * 1981-11-06 1984-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing new cyclic imine derivatives

Also Published As

Publication number Publication date
NL8302507A (nl) 1984-02-01
IT1169538B (it) 1987-06-03
BE897281A (fr) 1983-11-03
FR2530244A1 (fr) 1984-01-20
GB2124223A (en) 1984-02-15
GB2124223B (en) 1985-09-04
DE3325004A1 (de) 1984-01-19
SE8303862D0 (sv) 1983-07-06
IT8322053A0 (it) 1983-07-13
ES513980A0 (es) 1983-04-16
IT8322053A1 (it) 1985-01-13
CA1215048A (en) 1986-12-09
FR2530244B1 (fr) 1986-10-31
JPS5951272A (ja) 1984-03-24
GB8319108D0 (en) 1983-08-17
SE8303862L (sv) 1984-01-15

Similar Documents

Publication Publication Date Title
IL110321A0 (en) Intermediates to n-aryl and n-heteroarylamide and urea derivatives
DE3562374D1 (en) Compound having antibronchopneumopathic activity, process for its preparation and pharmaceutical compositions containing it
ES521548A0 (es) Un procedimiento de preparacion de nuevos acidos 2-4-difenil-metil)piperazinil-aceticos.(como divisional de la patente numero 509.358)
PT77459B (en) Process for the manufacture of novel topically administrable pharmaceutical compositions caontaining a phenyl-alkane-inferior-arboxilic acid or a 2-(2,6-dichloroaniline)-phenylacetic acid or a salt therefrom
IL73963A (en) N-(substituted benzyl)-phenyl acetic acid amides,their preparation and pharmaceutical compositions containing them
ES8503666A1 (es) Procedimiento para la preparacion de 1-ariloxi-2,3,4,5-tetrahidro-3-benzazepinas
PT87680A (pt) A process for the preparation of n-(aryl-,arylthio-arylsulfinyl-and arylsulfonyl-n,n'-(or n'n')alkylamino-alkyl ureas and cyanoguanidines and of pharmaceutical compositions containing the same
GR3023934T3 (en) New naphthalene amides and sulfonamides, process for their preparation and pharmaceutical compositions containing them
NO913391L (no) Fremgangsmaate for fremstilling av nye hetrazepinoide syreamider.
NO178660C (no) Analogifremgangsmåte for fremstilling av N-aryl-piperazinalkanamidforbindelser
DE3164741D1 (en) 2-(4-(diphenylmethylene)-1-piperidinyl)-acetic acids and their amides, their preparation and pharmaceutical preparations containing them
ES8305724A1 (es) Un procedimiento para la obtencion de la 2-(hexahidroazepin)-n-(2,6-dimetilfenil)acetamida.
ZA821660B (en) N-(2,2,2-trifluoroethyl)-n-alkyl-azolyloxyacetic acid amides, a process for their preparation and their use as herbicides, and new intermediate products for their preparation
HUT50105A (en) Process for producing cyclomethylene-1,2-dicarboxylic acids and pharmaceutical compositions containing them
DE3464244D1 (de) 1-(4'alkylsulfonylphenyl)-2-amino-1,3-propanediol n-substituted derivatives
IE780901L (en) Tetrazolyl-piperidinyl amides
ZA845930B (en) 1-(4'-alkylthiophenyl)-2-amino-1,3-propanediol n-substituted derivatives
DE2960627D1 (en) 2-(n-(2'chloro-4'-methyl-thienyl-3')-n-(cyclopropylmethyl)-amino) imidazoline (2), its acid addition salts, pharmaceutical preparations containing them and process for their preparation
JPS6470479A (en) Heterocylic carboxylic acid derivative, production thereof and agricultural and horticultural germicide containing said derivative as active ingredient
GB1467761A (en) Phenoxypropylamine derivatives and preparation thereof
GB889223A (en) Phenylpiperazinylalkyl esters and amides
ATE158576T1 (de) Alpha-aryl-alpha-hydroxy-beta- imidazolinylpropionsäureamide
JPS5636414A (en) Anticonvulsant agent containing omega-aminoalkoxystilbene or its acid addition salt as active constituent
AU561092B2 (en) N-(2,6 disubstituted aromatic)-n:-pyridinyl ureas
SE8206230D0 (sv) Novel cyclic imines, their preparation and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506