ES8304429A1 - Un procedimiento para la preparacion de soluciones minerales acuosas estables de levonantradol y n-metil-levonantradol. - Google Patents
Un procedimiento para la preparacion de soluciones minerales acuosas estables de levonantradol y n-metil-levonantradol.Info
- Publication number
- ES8304429A1 ES8304429A1 ES508609A ES508609A ES8304429A1 ES 8304429 A1 ES8304429 A1 ES 8304429A1 ES 508609 A ES508609 A ES 508609A ES 508609 A ES508609 A ES 508609A ES 8304429 A1 ES8304429 A1 ES 8304429A1
- Authority
- ES
- Spain
- Prior art keywords
- levonantradol
- methyl
- added
- final formulation
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE SOLUCIONES MICELARES ACUOSAS ESTABLES DE LEVONANTRADOL Y N-METIL-LEVONANTRADOL. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE DISUELVE A TEMPERATURA AMBIENTE EL LEVONANTRADOL O EL N-METIL-LEVONANTRADOL, O UNA SAL DE ADICION DE ACIDO, FARMACEUTICAMENTE ACEPTABLE, DE LOS MISMOS, EN UNA SOLUCION DE UN ANFIFILO NO IONICO CON UNA CONCENTRACION MICELAR CRITICA Y EN UN VOLUMEN INFERIOR AL VOLUMEN TOTAL DE AGUA QUE HA DE ESTAR PRESENTE EN LA FORMULACION FINAL; SEGUNDA, LA SOLUCION FORMADA SE SOMETE A AGITACION; TERCERA, SE AGREGAN LOS ANTIOXIDANTES, LOS EXCIPIENTES Y LOS TAMPONES; Y POR ULTIMO, SE AJUSTA EL PH Y SE LE AÑADE EL AGUA ADICIONAL NECESARIA PARA CONSEGUIR LA CONCENTRACION DESEADA DE INGREDIENTE ACTIVO EN LA FORMULACION FINAL. DE APLICACION EN PREPARADOS FARMACEUTICOS PARA USO PARENTERAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/223,672 US4406888A (en) | 1981-01-09 | 1981-01-09 | Aqueous micellar solutions of levonantradol and N-methyllevonantradol and lyophilic forms thereof for reconstitution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES508609A0 ES508609A0 (es) | 1983-03-01 |
| ES8304429A1 true ES8304429A1 (es) | 1983-03-01 |
Family
ID=22837540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508609A Expired ES8304429A1 (es) | 1981-01-09 | 1982-01-08 | Un procedimiento para la preparacion de soluciones minerales acuosas estables de levonantradol y n-metil-levonantradol. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4406888A (es) |
| EP (1) | EP0056681A3 (es) |
| JP (1) | JPS57136512A (es) |
| AU (1) | AU528316B2 (es) |
| CA (1) | CA1172569A (es) |
| CS (1) | CS235524B2 (es) |
| DK (1) | DK4382A (es) |
| ES (1) | ES8304429A1 (es) |
| FI (1) | FI813969L (es) |
| GR (1) | GR76514B (es) |
| HU (1) | HU186462B (es) |
| IL (1) | IL64731A0 (es) |
| NO (1) | NO820045L (es) |
| NZ (1) | NZ199415A (es) |
| PH (1) | PH17593A (es) |
| PT (1) | PT74257B (es) |
| ZA (1) | ZA82118B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE33239E (en) * | 1983-09-06 | 1990-06-26 | Farmaceutisk Laboratorium Ferring A/S | Packaged stable enema solution or suspension containing 5-aminosalicyclic acid |
| US4657900A (en) * | 1983-09-27 | 1987-04-14 | Rowell Laboratories | Pharmaceutical article of manufacture comprising a bisulfite stabilized aqueous solution of 5-aminosalicylic acid and method |
| GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
| US8163797B2 (en) * | 2003-12-31 | 2012-04-24 | Actavis Elizabeth Llc | Method of treating with stable pravastatin formulation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2391552A (en) * | 1942-02-25 | 1945-12-25 | Curtis David | Stabilized aromatic compounds |
| BE786427A (fr) * | 1971-07-19 | 1973-01-18 | Pfizer | Compositions aqueuses de doxycycline |
| SE7704749L (sv) * | 1976-05-17 | 1977-12-05 | Pfizer | Kinoliner och forfarande och mellanprodukter for framstellning derav |
| HU180917B (hu) | 1976-05-17 | 1983-05-30 | Pfizer | Eljárás 5, 6, 6a, 7-tetrahidro-benzo [c] kinolin-9(8H)-on-származékok előállítására |
| US4260764A (en) * | 1976-12-22 | 1981-04-07 | Pfizer Inc. | 9-Hydroxyoctahydrobenzo [C] quinolines and intermediates therefor |
| JPS54157818A (en) * | 1978-06-02 | 1979-12-13 | Tokyo Tanabe Co | Injectionable preparation of chlorethylnitrosourea compound |
| US4320124A (en) * | 1980-10-17 | 1982-03-16 | Pfizer Inc. | Composition for enhancing binding of a benzodiazepine to central benzodiazepine receptors and use thereof |
-
1981
- 1981-01-09 US US06/223,672 patent/US4406888A/en not_active Expired - Lifetime
- 1981-12-10 FI FI813969A patent/FI813969L/fi not_active Application Discontinuation
-
1982
- 1982-01-04 HU HU8211A patent/HU186462B/hu unknown
- 1982-01-05 EP EP82300018A patent/EP0056681A3/en not_active Withdrawn
- 1982-01-06 NZ NZ199415A patent/NZ199415A/en unknown
- 1982-01-07 PH PH26711A patent/PH17593A/en unknown
- 1982-01-07 JP JP57001342A patent/JPS57136512A/ja active Pending
- 1982-01-07 CA CA000393740A patent/CA1172569A/en not_active Expired
- 1982-01-08 IL IL64731A patent/IL64731A0/xx unknown
- 1982-01-08 NO NO820045A patent/NO820045L/no unknown
- 1982-01-08 ZA ZA82118A patent/ZA82118B/xx unknown
- 1982-01-08 ES ES508609A patent/ES8304429A1/es not_active Expired
- 1982-01-08 PT PT74257A patent/PT74257B/pt unknown
- 1982-01-08 CS CS82174A patent/CS235524B2/cs unknown
- 1982-01-08 DK DK4382A patent/DK4382A/da not_active Application Discontinuation
- 1982-01-08 AU AU79404/82A patent/AU528316B2/en not_active Ceased
- 1982-01-08 GR GR66964A patent/GR76514B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO820045L (no) | 1982-07-12 |
| PT74257A (en) | 1982-02-01 |
| HU186462B (en) | 1985-08-28 |
| PT74257B (en) | 1984-05-29 |
| PH17593A (en) | 1984-10-02 |
| ES508609A0 (es) | 1983-03-01 |
| EP0056681A3 (en) | 1983-07-20 |
| DK4382A (da) | 1982-07-10 |
| FI813969L (fi) | 1982-07-10 |
| IL64731A0 (en) | 1982-03-31 |
| JPS57136512A (en) | 1982-08-23 |
| CS235524B2 (en) | 1985-05-15 |
| US4406888A (en) | 1983-09-27 |
| AU7940482A (en) | 1982-07-22 |
| ZA82118B (en) | 1982-11-24 |
| GR76514B (es) | 1984-08-10 |
| EP0056681A2 (en) | 1982-07-28 |
| NZ199415A (en) | 1985-04-30 |
| CA1172569A (en) | 1984-08-14 |
| AU528316B2 (en) | 1983-04-21 |
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