ES8302638A1 - "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos". - Google Patents

"procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".

Info

Publication number
ES8302638A1
ES8302638A1 ES509514A ES509514A ES8302638A1 ES 8302638 A1 ES8302638 A1 ES 8302638A1 ES 509514 A ES509514 A ES 509514A ES 509514 A ES509514 A ES 509514A ES 8302638 A1 ES8302638 A1 ES 8302638A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
treatment
alkinyl
acylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509514A
Other languages
English (en)
Other versions
ES509514A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES8302638A1 publication Critical patent/ES8302638A1/es
Publication of ES509514A0 publication Critical patent/ES509514A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-(ACILAMINO-ARILOXI)-2-HIDROXI-3-ALQUINILAMINOPROPANOS Y DE SUS SALES DE ADICION DE ACIDO DE FORMULA (I), EN LA QUE R ES ALCOHILO C <003> ; Y R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES, CON UN DERIVADO DE AZETIDINOL DE FORMULA (III), EN LAS QUE R , R , R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES DE LOS VASOS CORONARIOS Y DE ARRITMIAS CARDIACAS Y COMO HIPOTENSORES.
ES509514A 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos". Granted ES509514A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803009047 DE3009047A1 (de) 1980-03-08 1980-03-08 Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES8302638A1 true ES8302638A1 (es) 1983-01-16
ES509514A0 ES509514A0 (es) 1983-01-16

Family

ID=6096693

Family Applications (3)

Application Number Title Priority Date Filing Date
ES500154A Granted ES500154A0 (es) 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos
ES509514A Granted ES509514A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".
ES509513A Granted ES509513A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES500154A Granted ES500154A0 (es) 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES509513A Granted ES509513A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".

Country Status (18)

Country Link
US (1) US4609672A (es)
EP (1) EP0035733B1 (es)
JP (1) JPS56139448A (es)
AT (1) ATE4639T1 (es)
AU (1) AU541492B2 (es)
CA (1) CA1150735A (es)
DE (2) DE3009047A1 (es)
DK (1) DK102581A (es)
ES (3) ES500154A0 (es)
FI (1) FI74272C (es)
GB (1) GB2071096B (es)
GR (1) GR74907B (es)
IE (1) IE52015B1 (es)
IL (1) IL62308A (es)
NO (1) NO150961C (es)
NZ (1) NZ196445A (es)
PT (1) PT72620B (es)
ZA (1) ZA811499B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3133719A1 (de) * 1981-08-26 1983-03-10 Boehringer Ingelheim KG, 6507 Ingelheim Neue 1-aryloxy-3-alkinylamino-2-propanole und verfahren zu ihrer herstellung
CZ301165B6 (cs) 1998-09-10 2009-11-25 Sanofi - Aventis Deutschland GmbH Použití benzensulfonyl(thio)mocovin pro lécení a profylaxi dysfunkcí autonomní nervové soustavy a použití benzensulfonyl(thio)mocovin v kombinaci s beta-receptorovými blokátory

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH546227A (en) * 1969-08-08 1974-02-28 Boehringer Sohn Ingelheim 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane
CH546224A (en) * 1969-08-08 1974-02-28 Boehringer Sohn Ingelheim 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane
DE2403809C2 (de) * 1974-01-26 1986-02-27 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropane und Verfahren zu ihrer Herstellung und pharmazeutische Präparate
DE2309887C2 (de) * 1973-02-28 1983-11-10 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
DE3009036A1 (de) * 1980-03-08 1981-09-24 C.H. Boehringer Sohn, 6507 Ingelheim Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NZ196445A (en) 1984-05-31
IE52015B1 (en) 1987-05-27
GR74907B (es) 1984-07-12
GB2071096B (en) 1983-09-14
NO150961B (no) 1984-10-08
ZA811499B (en) 1982-11-24
ES8303300A1 (es) 1983-02-01
AU6815781A (en) 1981-09-17
ES8205396A1 (es) 1982-06-01
NO810764L (no) 1981-09-09
GB2071096A (en) 1981-09-16
FI810714L (fi) 1981-09-09
ES500154A0 (es) 1982-06-01
FI74272B (fi) 1987-09-30
IL62308A (en) 1984-12-31
IL62308A0 (en) 1981-05-20
ES509514A0 (es) 1983-01-16
JPS56139448A (en) 1981-10-30
DE3009047A1 (de) 1981-09-24
DE3160861D1 (en) 1983-10-20
AU541492B2 (en) 1985-01-10
US4609672A (en) 1986-09-02
IE810486L (en) 1981-09-08
EP0035733A1 (de) 1981-09-16
FI74272C (fi) 1988-01-11
ES509513A0 (es) 1983-02-01
DK102581A (da) 1981-09-09
EP0035733B1 (de) 1983-09-14
PT72620A (de) 1981-04-01
ATE4639T1 (de) 1983-09-15
PT72620B (de) 1982-11-15
NO150961C (no) 1985-01-16
CA1150735A (en) 1983-07-26

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