CH546224A - 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane - Google Patents

1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane

Info

Publication number
CH546224A
CH546224A CH546224DA CH546224A CH 546224 A CH546224 A CH 546224A CH 546224D A CH546224D A CH 546224DA CH 546224 A CH546224 A CH 546224A
Authority
CH
Switzerland
Prior art keywords
cpd
corresp
reacting
hydrolysing
protecting
Prior art date
Application number
Other languages
German (de)
Inventor
H Koppe
K Zeile
W Traunecker
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1940566A external-priority patent/DE1940566C3/en
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of CH546224A publication Critical patent/CH546224A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The title cpd. and its optical isomers and acid addn. salts have beta-adrenolytic activity and may be used for treatment or prophylaxis of heart diseases and arrythmia, esp. tachycardia. They may be prepd. (a) by reacting a cpd. (II): (where Z = or CHOH-CH2Hal) with N,N'-diethyl-urea, (b) reacting (II) with ethylamine, (c) reacting 3-(o-cyanophenoxy)-2-hydroxypropylamine with a cpd. C2H5X (where is a labile anionic gp). (d) replacing the protecting gp. of the corresp. protected -OH cpd. by H, (e) hydrolysing 3-ethyl-5-(2-cyanophenoxymethyl)-oxazolidinone-(2), (f) hydrolysing or pyrolysing the corresp. urea deriv. (g) splitting off the protecting gp. from the corresp. N-protected cpd. (h) converting a ring substituent into a cyano gp.
CH546224D 1969-08-08 1970-08-05 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane CH546224A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1940566A DE1940566C3 (en) 1969-08-08 1969-08-08 1- (2-Nitrilophenoxy) -2-hydroxy-3ethylaminopropane, process for its preparation and pharmaceuticals containing it
CH116573 1970-08-05

Publications (1)

Publication Number Publication Date
CH546224A true CH546224A (en) 1974-02-28

Family

ID=25686859

Family Applications (1)

Application Number Title Priority Date Filing Date
CH546224D CH546224A (en) 1969-08-08 1970-08-05 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane

Country Status (1)

Country Link
CH (1) CH546224A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035733A1 (en) * 1980-03-08 1981-09-16 C.H. Boehringer Sohn 1-(Acylamino-aryloxy-)2-hydroxy-3-alkinyl-amino propanes and processes for their manufacture
EP0035734A1 (en) * 1980-03-08 1981-09-16 C.H. Boehringer Sohn 1-(Acylamino-aryloxy-)2-hydroxy-3-alkinyl-amino propanes and processes for their manufacture

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035733A1 (en) * 1980-03-08 1981-09-16 C.H. Boehringer Sohn 1-(Acylamino-aryloxy-)2-hydroxy-3-alkinyl-amino propanes and processes for their manufacture
EP0035734A1 (en) * 1980-03-08 1981-09-16 C.H. Boehringer Sohn 1-(Acylamino-aryloxy-)2-hydroxy-3-alkinyl-amino propanes and processes for their manufacture

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Legal Events

Date Code Title Description
PL Patent ceased