CH546225A - 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane - Google Patents
1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propaneInfo
- Publication number
- CH546225A CH546225A CH546225DA CH546225A CH 546225 A CH546225 A CH 546225A CH 546225D A CH546225D A CH 546225DA CH 546225 A CH546225 A CH 546225A
- Authority
- CH
- Switzerland
- Prior art keywords
- cpd
- corresp
- reacting
- hydrolysing
- protecting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The title cpd. and its optical isomers and acid addn. salts have beta-adrenolytic activity and may be used for treatment or prophylaxis of heart diseases and arrythmia, esp. tachycardia. They may be prepd. (a) by reacting a cpd. (II): (where Z = or CHOH-CH2Hal) with N,N'-diethyl-urea, (b) reacting (II) with ethylamine, (c) reacting 3-(o-cyanophenoxy)-2-hydroxypropylamine with a cpd. C2H5X (where is a labile anionic gp). (d) replacing the protecting gp. of the corresp. protected -OH cpd. by H, (e) hydrolysing 3-ethyl-5-(2-cyanophenoxymethyl)-oxazolidinone-(2), (f) hydrolysing or pyrolysing the corresp. urea deriv. (g) splitting off the protecting gp. from the corresp. N-protected cpd. (h) converting a ring substituent into a cyano gp.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1940566A DE1940566C3 (en) | 1969-08-08 | 1969-08-08 | 1- (2-Nitrilophenoxy) -2-hydroxy-3ethylaminopropane, process for its preparation and pharmaceuticals containing it |
CH116673 | 1970-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH546225A true CH546225A (en) | 1974-02-28 |
Family
ID=25686868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH546225D CH546225A (en) | 1969-08-08 | 1970-08-05 | 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH546225A (en) |
-
1970
- 1970-08-05 CH CH546225D patent/CH546225A/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PL | Patent ceased |