ES8205396A1 - Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos - Google Patents

Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos

Info

Publication number
ES8205396A1
ES8205396A1 ES500154A ES500154A ES8205396A1 ES 8205396 A1 ES8205396 A1 ES 8205396A1 ES 500154 A ES500154 A ES 500154A ES 500154 A ES500154 A ES 500154A ES 8205396 A1 ES8205396 A1 ES 8205396A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
treatment
alkinyl
acylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500154A
Other languages
English (en)
Other versions
ES500154A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES500154A0 publication Critical patent/ES500154A0/es
Publication of ES8205396A1 publication Critical patent/ES8205396A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrane Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 1-(ACILAMINO-ARILOXI)-2-HIDROXI-3ALQUINILAMINOPROPANOS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 ES UN ALCOHILO C4-20; R3 Y R4 SON HIDROGENO O ALCOHILO C1-3, O CONJUNTAMENTE FORMAN EL GRUPO (CH2)P, VALIENDO "P" DE 4 A 6, Y R2 PUEDE SER VARIOS TIPOS DE RADIALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA H2N-CR3R4-C=CH, EN LA QUE Z ES ESLRADIAL DE FORMULA (III) O EL RADIAL DE FORMULA -CHOH-CH2-HAL, SIENDO HAL UN HALOGENO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LAREACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A LA TEMPERATURA DE REFLUJO DEL MEDIO DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES ADE LOS VASOS CORONARIOS Y DE ARRITMIAS CARDIACAS.
ES500154A 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos Expired ES8205396A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803009047 DE3009047A1 (de) 1980-03-08 1980-03-08 Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ES500154A0 ES500154A0 (es) 1982-06-01
ES8205396A1 true ES8205396A1 (es) 1982-06-01

Family

ID=6096693

Family Applications (3)

Application Number Title Priority Date Filing Date
ES500154A Expired ES8205396A1 (es) 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos
ES509513A Granted ES509513A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".
ES509514A Expired ES8302638A1 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES509513A Granted ES509513A0 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".
ES509514A Expired ES8302638A1 (es) 1980-03-08 1982-02-11 "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".

Country Status (18)

Country Link
US (1) US4609672A (es)
EP (1) EP0035733B1 (es)
JP (1) JPS56139448A (es)
AT (1) ATE4639T1 (es)
AU (1) AU541492B2 (es)
CA (1) CA1150735A (es)
DE (2) DE3009047A1 (es)
DK (1) DK102581A (es)
ES (3) ES8205396A1 (es)
FI (1) FI74272C (es)
GB (1) GB2071096B (es)
GR (1) GR74907B (es)
IE (1) IE52015B1 (es)
IL (1) IL62308A (es)
NO (1) NO150961C (es)
NZ (1) NZ196445A (es)
PT (1) PT72620B (es)
ZA (1) ZA811499B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3133719A1 (de) * 1981-08-26 1983-03-10 Boehringer Ingelheim KG, 6507 Ingelheim Neue 1-aryloxy-3-alkinylamino-2-propanole und verfahren zu ihrer herstellung
IL141414A0 (en) 1998-09-10 2002-03-10 Aventis Pharma Gmbh Use of benzenesulfonyl (thio) ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl (thio) ureas in combination with beta-receptor blockers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH546227A (en) * 1969-08-08 1974-02-28 Boehringer Sohn Ingelheim 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane
CH546224A (en) * 1969-08-08 1974-02-28 Boehringer Sohn Ingelheim 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane
AT330150B (de) * 1973-02-28 1976-06-10 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen
DE2309887C2 (de) * 1973-02-28 1983-11-10 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen
DE2403809C2 (de) * 1974-01-26 1986-02-27 C.H. Boehringer Sohn, 6507 Ingelheim 1-Aryloxy-2-hydroxy-3-alkinylaminopropane und Verfahren zu ihrer Herstellung und pharmazeutische Präparate
DE3009036A1 (de) * 1980-03-08 1981-09-24 C.H. Boehringer Sohn, 6507 Ingelheim Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NZ196445A (en) 1984-05-31
AU541492B2 (en) 1985-01-10
PT72620A (de) 1981-04-01
DE3160861D1 (en) 1983-10-20
CA1150735A (en) 1983-07-26
EP0035733A1 (de) 1981-09-16
FI74272C (fi) 1988-01-11
ES509514A0 (es) 1983-01-16
ZA811499B (en) 1982-11-24
US4609672A (en) 1986-09-02
DK102581A (da) 1981-09-09
GR74907B (es) 1984-07-12
NO150961B (no) 1984-10-08
EP0035733B1 (de) 1983-09-14
IL62308A0 (en) 1981-05-20
ES8303300A1 (es) 1983-02-01
ES509513A0 (es) 1983-02-01
FI810714L (fi) 1981-09-09
IE810486L (en) 1981-09-08
NO810764L (no) 1981-09-09
IE52015B1 (en) 1987-05-27
NO150961C (no) 1985-01-16
JPS56139448A (en) 1981-10-30
GB2071096A (en) 1981-09-16
ES500154A0 (es) 1982-06-01
AU6815781A (en) 1981-09-17
DE3009047A1 (de) 1981-09-24
GB2071096B (en) 1983-09-14
PT72620B (de) 1982-11-15
IL62308A (en) 1984-12-31
FI74272B (fi) 1987-09-30
ATE4639T1 (de) 1983-09-15
ES8302638A1 (es) 1983-01-16

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ES8302638A1 (es) "procedimiento para la preparacion de nuevos 1-(acilamino-arloxi-)2-hidroxi-3-alquinilaminopropanos".
ES8302637A1 (es) "procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos".
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