ES8301197A1 - Un procedimiento para la preparacion de tioeteres. - Google Patents

Un procedimiento para la preparacion de tioeteres.

Info

Publication number
ES8301197A1
ES8301197A1 ES501496A ES501496A ES8301197A1 ES 8301197 A1 ES8301197 A1 ES 8301197A1 ES 501496 A ES501496 A ES 501496A ES 501496 A ES501496 A ES 501496A ES 8301197 A1 ES8301197 A1 ES 8301197A1
Authority
ES
Spain
Prior art keywords
biologically active
preparing
therapeutically effective
active agents
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501496A
Other languages
English (en)
Spanish (es)
Other versions
ES501496A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES501496A0 publication Critical patent/ES501496A0/es
Publication of ES8301197A1 publication Critical patent/ES8301197A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/38One sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36Sulfur atom
    • C07D473/38Sulfur atom attached in position 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Manufacturing Of Electrical Connectors (AREA)
  • Steroid Compounds (AREA)
ES501496A 1980-04-21 1981-04-20 Un procedimiento para la preparacion de tioeteres. Expired ES8301197A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14198180A 1980-04-21 1980-04-21

Publications (2)

Publication Number Publication Date
ES501496A0 ES501496A0 (es) 1982-12-01
ES8301197A1 true ES8301197A1 (es) 1982-12-01

Family

ID=22498074

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501496A Expired ES8301197A1 (es) 1980-04-21 1981-04-20 Un procedimiento para la preparacion de tioeteres.

Country Status (10)

Country Link
US (1) US4443435A (cg-RX-API-DMAC7.html)
EP (1) EP0038541B1 (cg-RX-API-DMAC7.html)
JP (1) JPS572252A (cg-RX-API-DMAC7.html)
AT (1) ATE21388T1 (cg-RX-API-DMAC7.html)
DE (1) DE3175100D1 (cg-RX-API-DMAC7.html)
DK (1) DK172081A (cg-RX-API-DMAC7.html)
ES (1) ES8301197A1 (cg-RX-API-DMAC7.html)
GR (1) GR75219B (cg-RX-API-DMAC7.html)
IE (1) IE52017B1 (cg-RX-API-DMAC7.html)
PT (1) PT72877B (cg-RX-API-DMAC7.html)

Families Citing this family (45)

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DK172081A (da) * 1980-04-21 1981-10-22 Merck & Co Inc Mercaptoforbindelse og fremgangsmaade til fremstilling deraf
JPS57183778A (en) * 1981-04-30 1982-11-12 Nippon Synthetic Chem Ind Co Ltd:The S-(3-phthalidyl)-l-cysteine and its preparation
US4454065A (en) * 1982-05-18 1984-06-12 Smithkline Beckman Corporation Oligopeptide prodrugs
DK302883D0 (da) * 1983-06-30 1983-06-30 Hans Bundgaard Allopurinol prodrugs
CS249576B1 (en) * 1984-12-22 1987-04-16 Antonin Cerny 6-purinyl n-(2-chlorethyl)carbamate and thiocarbamate and method of their production
WO1986004929A1 (fr) 1985-02-22 1986-08-28 Kawasaki Steel Corporation Procede de production de plaques d'acier au silicium unidirectionnelles avec une perte de fer extremement faible
US5203928A (en) * 1986-03-25 1993-04-20 Kawasaki Steel Corporation Method of producing low iron loss grain oriented silicon steel thin sheets having excellent surface properties
JPH0615694B2 (ja) * 1987-04-17 1994-03-02 川崎製鉄株式会社 方向性けい素鋼板の鉄損低減方法
DE3889600T2 (de) * 1987-08-01 1994-09-01 Kawasaki Steel Co Kornorientierte Elektrobleche mit sehr geringen Eisenverlusten und Verfahren zum Herstellen dieser Bleche.
US5120740A (en) * 1989-11-03 1992-06-09 Wisconsin Alumni Research Foundation Prodrugs of 6-mercaptopurine and 6-thioguanine
JPH0723511B2 (ja) * 1989-12-07 1995-03-15 新日本製鐵株式会社 一方向性電磁鋼帯の処理装置
DE69420058T2 (de) * 1993-01-12 2000-04-27 Nippon Steel Corp., Tokio/Tokyo Kornorientiertes Elektroblech mit sehr geringen Eisenverlusten und Herstellungsverfahren
US5823679A (en) * 1993-09-17 1998-10-20 Omega Engineering, Inc. Method and apparatus for measuring temperature including aiming light
FR2773214B1 (fr) 1996-12-11 2002-05-31 Omega Engineering Procede et dispositif pour la mesure par infrarouge de la temperature d'une surface
DE69810852T2 (de) * 1997-07-17 2003-06-05 Kawasaki Steel Corp., Kobe Kornorientiertes Elektrostahlblech mit ausgezeichneten magnetischen Eigenschaften und dessen Herstellungsverfahren
KR100586440B1 (ko) 2001-07-16 2006-06-08 신닛뽄세이테쯔 카부시키카이샤 고자장 철손과 피막 특성이 우수한 초고자속밀도 일방향성전자강판과 그 제조 방법
US8188067B2 (en) 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
CA2560997A1 (en) * 2004-04-01 2005-10-27 Teva Pharmaceutical Industries Ltd. Delayed release formulations of 6-mercaptopurine
EP2096185B1 (en) 2006-11-22 2014-08-13 Nippon Steel & Sumitomo Metal Corporation Unidirectionally grain oriented electromagnetic steel sheet having excellent film adhesion, and method for manufacturing the same
WO2008074132A1 (en) 2006-12-19 2008-06-26 Methylgene Inc. Inhibitors of histone deacetylase and prodrugs thereof
CA2721728A1 (en) * 2008-04-18 2009-10-22 Teva Pharmaceutical Industries Ltd. Treatment of inflammatory bowel disease with 6-mercaptopurine
JP5923879B2 (ja) 2010-06-29 2016-05-25 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP5927754B2 (ja) 2010-06-29 2016-06-01 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
US9330839B2 (en) 2010-08-06 2016-05-03 Jfe Steel Corporation Grain oriented electrical steel sheet and method for manufacturing the same
JP5998424B2 (ja) 2010-08-06 2016-09-28 Jfeスチール株式会社 方向性電磁鋼板
JP5853352B2 (ja) 2010-08-06 2016-02-09 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP5593942B2 (ja) 2010-08-06 2014-09-24 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
RU2576355C1 (ru) 2011-12-26 2016-02-27 ДжФЕ СТИЛ КОРПОРЕЙШН Текстурированный лист электротехнической стали
KR101638890B1 (ko) 2011-12-27 2016-07-12 제이에프이 스틸 가부시키가이샤 방향성 전자 강판의 철손 개선 장치
JP5761377B2 (ja) 2011-12-27 2015-08-12 Jfeスチール株式会社 方向性電磁鋼板
CN104024455B (zh) 2011-12-28 2016-05-25 杰富意钢铁株式会社 方向性电磁钢板及其铁损改善方法
US10804015B2 (en) 2011-12-29 2020-10-13 Posco Electrical steel sheet and method for manufacturing the same
WO2013160955A1 (ja) 2012-04-26 2013-10-31 Jfeスチール株式会社 方向性電磁鋼板およびその製造方法
JP5971157B2 (ja) 2013-03-11 2016-08-17 Jfeスチール株式会社 塗布装置および塗布方法
JP5668795B2 (ja) 2013-06-19 2015-02-12 Jfeスチール株式会社 方向性電磁鋼板およびそれを用いた変圧器鉄心
CN105555984B (zh) 2013-09-19 2017-07-07 杰富意钢铁株式会社 方向性电磁钢板及其制造方法
JP6215673B2 (ja) 2013-11-29 2017-10-18 東芝産業機器システム株式会社 ベクトル磁気特性制御材、および、鉄心
KR101639920B1 (ko) 2014-12-26 2016-07-15 주식회사 포스코 방향성 전기강판의 자구미세화 장치 및 그 방법
WO2017066619A1 (en) 2015-10-16 2017-04-20 Teva Pharmaceutical Industries Ltd. Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine
CA3054528C (en) 2017-02-28 2021-09-07 Jfe Steel Corporation Grain-oriented electrical steel sheet and production method therefor
KR102880080B1 (ko) 2020-11-27 2025-10-31 제이에프이 스틸 가부시키가이샤 방향성 전자 강판 및 그의 제조 방법
CN115724824B (zh) * 2021-09-01 2024-03-15 四川大学 3-(酰胺烷硫基)苯酞类化合物、其制备方法和用途
KR20240113807A (ko) 2022-01-06 2024-07-23 제이에프이 스틸 가부시키가이샤 방향성 전자 강판
EP4582567A4 (en) 2022-09-09 2025-12-24 Jfe Steel Corp GRAIN-ORIENTED ELECTROMAGNETIC STEEL SHEET
KR20240098941A (ko) 2022-12-21 2024-06-28 주식회사 포스코 방향성 전기강판 및 그 제조방법

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US2852506A (en) * 1955-10-31 1958-09-16 American Cyanamid Co Method of preparing aminodeoxyglycosidopurines
US2844576A (en) * 1955-11-22 1958-07-22 American Cyanamid Co Preparation of purines
BE733669A (cg-RX-API-DMAC7.html) * 1968-06-04 1969-11-27
US3915958A (en) * 1972-05-22 1975-10-28 Icn Pharmaceuticals 6-Substituted purine nucleotides
JPS49117479A (cg-RX-API-DMAC7.html) * 1973-05-30 1974-11-09
US3957803A (en) * 1975-01-06 1976-05-18 Interx Research Corporation Certain transient pro-drug forms of phenylbutazone
US4275064A (en) * 1976-02-06 1981-06-23 Interx Research Corporation Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents
US4061753A (en) * 1976-02-06 1977-12-06 Interx Research Corporation Treating psoriasis with transient pro-drug forms of xanthine derivatives
US4235887A (en) * 1977-04-13 1980-11-25 The Upjohn Company Process for therapeutic treatment
JPS5589257A (en) * 1978-12-22 1980-07-05 Kanebo Ltd New easily-absorbable sulfur-containing prodrug of non- steroidal antiphlogistic, and their drug compositions
NZ196349A (en) * 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered polar bioactive agents
DK172081A (da) * 1980-04-21 1981-10-22 Merck & Co Inc Mercaptoforbindelse og fremgangsmaade til fremstilling deraf

Also Published As

Publication number Publication date
JPS572252A (en) 1982-01-07
GR75219B (cg-RX-API-DMAC7.html) 1984-07-13
ES501496A0 (es) 1982-12-01
PT72877A (en) 1981-05-01
US4443435A (en) 1984-04-17
EP0038541B1 (en) 1986-08-13
IE52017B1 (en) 1987-05-27
JPH0226630B2 (cg-RX-API-DMAC7.html) 1990-06-12
ATE21388T1 (de) 1986-08-15
EP0038541A1 (en) 1981-10-28
DK172081A (da) 1981-10-22
PT72877B (en) 1983-03-29
DE3175100D1 (en) 1986-09-18
IE810869L (en) 1982-10-21

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303