ES8300679A1 - Un procedimiento para la preparacion de nuevos derivados de 2-propanol - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 2-propanol

Info

Publication number
ES8300679A1
ES8300679A1 ES502656A ES502656A ES8300679A1 ES 8300679 A1 ES8300679 A1 ES 8300679A1 ES 502656 A ES502656 A ES 502656A ES 502656 A ES502656 A ES 502656A ES 8300679 A1 ES8300679 A1 ES 8300679A1
Authority
ES
Spain
Prior art keywords
alkylamino
phenoxy
propanol
substituted
beta receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502656A
Other languages
English (en)
Other versions
ES502656A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Publication of ES502656A0 publication Critical patent/ES502656A0/es
Publication of ES8300679A1 publication Critical patent/ES8300679A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2-PROPANOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES ISOPOPILO O TERCBUTILO; R Y R PUEDEN SER VARIOS TIPOS DE RADICALES; Y N VALE 1 O 2. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA H NR , EN LAS QUE X ES UN GRUPO HIDROXI; Z ES UN GRUPO HIDROXI ESTERIFICADO REACTIVO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE CONDENSACION BASICO, A UNA TEMPERATURA ENTRE 100 Y 300<025>C. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL INFARTO DE MIOCARDIO AGUDO Y POR SU ACTIVIDAD DE BLOQUEO DE LOS RECEPTORES BETA.
ES502656A 1980-06-02 1981-06-01 Un procedimiento para la preparacion de nuevos derivados de 2-propanol Expired ES8300679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8004087A SE8004087L (sv) 1980-06-02 1980-06-02 Nya parasubstituerade 3-fenoxi-1-alkylaminopropanol-2-er med betareceptorblockerande egenskaper, samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma, och metod att behandla akut ...

Publications (2)

Publication Number Publication Date
ES502656A0 ES502656A0 (es) 1982-11-01
ES8300679A1 true ES8300679A1 (es) 1982-11-01

Family

ID=20341101

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502656A Expired ES8300679A1 (es) 1980-06-02 1981-06-01 Un procedimiento para la preparacion de nuevos derivados de 2-propanol

Country Status (25)

Country Link
EP (1) EP0041491B1 (es)
JP (1) JPS5724335A (es)
KR (1) KR850000869B1 (es)
AT (1) ATE11529T1 (es)
AU (1) AU548290B2 (es)
CS (1) CS241484B2 (es)
DD (1) DD159328A5 (es)
DE (1) DE3168595D1 (es)
DK (1) DK154208C (es)
ES (1) ES8300679A1 (es)
FI (1) FI71725C (es)
GR (1) GR74571B (es)
HU (1) HU184860B (es)
IE (1) IE53801B1 (es)
LU (2) LU88317I2 (es)
MY (1) MY8600219A (es)
NL (1) NL930102I2 (es)
NO (1) NO151282C (es)
NZ (1) NZ197237A (es)
PH (1) PH16135A (es)
PL (1) PL135823B1 (es)
PT (1) PT73111B (es)
SE (1) SE8004087L (es)
SU (1) SU1156592A3 (es)
ZA (1) ZA812981B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4593119A (en) * 1980-11-28 1986-06-03 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
US4559359A (en) * 1981-06-23 1985-12-17 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4455317A (en) * 1981-06-23 1984-06-19 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4454154A (en) * 1981-06-23 1984-06-12 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4578403A (en) * 1981-06-23 1986-03-25 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US5135926A (en) * 1984-03-14 1992-08-04 Bodor Nicholas S Soft β-adrenergic blocking agents
WO1985004168A1 (en) * 1984-03-14 1985-09-26 Bodor Nicholas S SOFT beta-ADRENERGIC BLOCKING AGENTS
US4829086A (en) * 1984-03-14 1989-05-09 Bodor Nicholas S Soft β-adrenergic blocking agents
US5202347A (en) * 1984-03-14 1993-04-13 Bodor Nicholas S Soft β-adrenergic blocking agents
US5334601A (en) * 1984-03-14 1994-08-02 Bodor Nicholas S Soft β-adrenergic blocking agents
WO1985004580A1 (en) * 1984-04-09 1985-10-24 American Hospital Supply Corporation Pharmaceutical composition and method for treatment or prophylaxis of cardiac disorders
EP0279844A4 (en) * 1986-09-02 1990-06-05 Du Pont AFLÖSUNG VON DE dl-METHYL-3-4- (2-HYDROXY-3-ISOPROPYLAMINO) PROPOXY] PHENYLPROPIONAT (DL-ESMOLOL)].
US5274002A (en) * 1987-04-14 1993-12-28 Warner-Lambert Company Trisubstituted phenyl analogs having activity for congestive heart failure
CA2015730C (en) * 1989-05-12 1997-10-07 Sadahiko Iguchi Esters of phenylalkanoic acid
US5232948A (en) * 1990-09-10 1993-08-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted monocyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
EP2986599A1 (en) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
EP3101303A4 (en) * 2014-01-29 2017-10-11 Sumitomo Bakelite Co.,Ltd. Brake pad and caliper device
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CR20210441A (es) 2019-01-18 2022-03-11 Astrazeneca Ab Inhibidores de la pcsk9 y métodos de uso de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB673413A (en) * 1950-03-22 1952-06-04 Rhone Poulenc Sa New local anaesthetics which are substituted benzoic esters and processes for making the same
CH512427A (de) * 1967-12-18 1971-09-15 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen racemischen oder optisch aktiven 1-Phenoxy-2-hydroxy-3-sec. -alkylaminopropanen
GB1285038A (en) 1969-02-21 1972-08-09 Ici Ltd Alkanolamine derivatives
SE354851B (es) * 1970-02-18 1973-03-26 Haessle Ab
FR2132570B1 (es) 1971-04-09 1974-08-02 Lipha
PT66890B (fr) * 1976-08-21 1979-01-25 Hexachimie Procede pour la preparation des aryloxy-1 amino-3 propanol-2

Also Published As

Publication number Publication date
LU88348I2 (fr) 1994-09-09
NL930102I1 (nl) 1993-10-01
AU548290B2 (en) 1985-12-05
KR850000869B1 (ko) 1985-06-22
ATE11529T1 (de) 1985-02-15
CS404781A2 (en) 1985-06-13
DE3168595D1 (en) 1985-03-14
DD159328A5 (de) 1983-03-02
EP0041491B1 (en) 1985-01-30
PT73111A (en) 1981-07-01
ES502656A0 (es) 1982-11-01
NL930102I2 (nl) 1994-12-01
HU184860B (en) 1984-10-29
DK154208C (da) 1989-03-20
NZ197237A (en) 1985-01-31
AU7116681A (en) 1982-12-02
NO151282C (no) 1985-03-13
FI71725B (fi) 1986-10-31
NO151282B (no) 1984-12-03
FI811671L (fi) 1981-12-03
DK239581A (da) 1981-12-03
SU1156592A3 (ru) 1985-05-15
KR830006177A (ko) 1983-09-20
EP0041491A1 (en) 1981-12-09
ZA812981B (en) 1982-05-26
PL135823B1 (en) 1985-12-31
IE53801B1 (en) 1989-03-01
JPS5724335A (en) 1982-02-08
MY8600219A (en) 1986-12-31
PL231450A1 (en) 1983-03-28
FI71725C (fi) 1987-02-09
LU88317I2 (fr) 1994-05-04
JPS639501B2 (es) 1988-02-29
DK154208B (da) 1988-10-24
SE8004087L (sv) 1981-12-03
NO811799L (no) 1981-12-03
CS241484B2 (en) 1986-03-13
PH16135A (en) 1983-07-08
GR74571B (es) 1984-06-29
IE811217L (en) 1981-12-02
PT73111B (en) 1983-05-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020701