ES8206526A1 - Procedimiento para preparar 1-azabiciclo(3.3.0)octano-2,8- diona - Google Patents

Procedimiento para preparar 1-azabiciclo(3.3.0)octano-2,8- diona

Info

Publication number
ES8206526A1
ES8206526A1 ES505456A ES505456A ES8206526A1 ES 8206526 A1 ES8206526 A1 ES 8206526A1 ES 505456 A ES505456 A ES 505456A ES 505456 A ES505456 A ES 505456A ES 8206526 A1 ES8206526 A1 ES 8206526A1
Authority
ES
Spain
Prior art keywords
compound
pyrrolizine
dione
dihydro
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505456A
Other languages
English (en)
Other versions
ES505456A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES505456A0 publication Critical patent/ES505456A0/es
Publication of ES8206526A1 publication Critical patent/ES8206526A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR 1-AZABICICLO(3.3.0)OCTANO-2,8-DIONA. CONSISTE EN LA REACCION DE HIDROGENACION CATALITICA, BAJO PRESION, DEL ESTR DIMETILICO DEL ACIDO Y-NITROPIMELICO DE FORMULA (I), UTILIZANDO PALADIO SOBRE CARBONO COMO CATALIZADOR, OBTENIENDOSE PIRROLIDIN-2-ONA-5-PROPANO DE METILO Y EL ACIDO CORRESPONDIENTE A ESTE ESTER, SEGUIDA DE LA HIDROLISIS CON HIDROXIDO SODICO Y REACCION CON ANHIDRIDO ACETICO. SI SE UTILIZA NIQUEL RANEY COMO CATALIZADOR DE HIDROGENACION SE OBTIENE SOLO EL ESTER EN LA PRIMERA ETAPA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA SENILIDAD Y DELA AMNESIA INDUCIDA Y PARA MEJORAR LA MEMORIA.
ES505456A 1980-09-15 1981-09-14 Procedimiento para preparar 1-azabiciclo(3.3.0)octano-2,8- diona Expired ES8206526A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18694580A 1980-09-15 1980-09-15
US06/290,114 US4372966A (en) 1980-09-15 1981-08-07 Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator

Publications (2)

Publication Number Publication Date
ES505456A0 ES505456A0 (es) 1982-08-16
ES8206526A1 true ES8206526A1 (es) 1982-08-16

Family

ID=26882585

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505456A Expired ES8206526A1 (es) 1980-09-15 1981-09-14 Procedimiento para preparar 1-azabiciclo(3.3.0)octano-2,8- diona

Country Status (15)

Country Link
US (1) US4372966A (es)
EP (1) EP0048132B1 (es)
AU (1) AU545556B2 (es)
CA (1) CA1154679A (es)
DD (1) DD201797A5 (es)
DE (1) DE3165563D1 (es)
ES (1) ES8206526A1 (es)
FI (1) FI812853L (es)
GR (1) GR75026B (es)
HU (1) HU184883B (es)
IE (1) IE51514B1 (es)
IL (1) IL63663A (es)
NO (1) NO813122L (es)
NZ (1) NZ198342A (es)
PH (1) PH18690A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547519A (en) * 1982-05-24 1985-10-15 Warner-Lambert Company Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia
US4559358A (en) * 1982-05-24 1985-12-17 Warner-Lambert Company 5-Oxo-2-pyrrolidinepropanoic acid and derivatives for reversing electroshock amnesia
US4525476A (en) * 1983-05-26 1985-06-25 Warner-Lambert Company N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids and derivatives as cognition activators
US4551470A (en) * 1983-08-29 1985-11-05 Warner-Lambert Company Hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid and derivatives, and use for reversing electroconvulsive shock amnesia
US4562195A (en) * 1984-02-02 1985-12-31 Warner-Lambert Company Reversing amnesia with saturated tricyclic nitrogen-containing diones
US4530929A (en) * 1984-02-02 1985-07-23 Warner-Lambert Company Benzotricyclic nitrogen-containing diones and their use in reversing electroconvulsive shock-induced amnesia
US4548947A (en) * 1984-05-07 1985-10-22 Warner-Lambert Company 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H-]diones and use for reversing amnesia
US4677098A (en) * 1985-11-22 1987-06-30 Warner-Lambert Company Substituted dihydro-1H-pyrolizine-3,5(2H,6H)-diones
US4663464A (en) * 1986-03-21 1987-05-05 Warner-Lambert Company Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione
IT1233860B (it) * 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa

Also Published As

Publication number Publication date
NZ198342A (en) 1984-11-09
DE3165563D1 (en) 1984-09-20
EP0048132B1 (en) 1984-08-15
US4372966A (en) 1983-02-08
ES505456A0 (es) 1982-08-16
GR75026B (es) 1984-07-12
IE51514B1 (en) 1987-01-07
CA1154679A (en) 1983-10-04
AU7479981A (en) 1982-03-25
FI812853L (fi) 1982-03-16
IL63663A (en) 1984-12-31
PH18690A (en) 1985-09-05
HU184883B (en) 1984-10-29
DD201797A5 (de) 1983-08-10
IE812133L (en) 1982-03-15
AU545556B2 (en) 1985-07-18
EP0048132A3 (en) 1982-05-12
NO813122L (no) 1982-03-16
IL63663A0 (en) 1981-11-30
EP0048132A2 (en) 1982-03-24

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