ES8204989A1 - Procedimiento para la separacion de un enantiomero del acido (fenil-2-benzotiazolil-6)-2 proponico dde la mezcla race- mica. - Google Patents

Procedimiento para la separacion de un enantiomero del acido (fenil-2-benzotiazolil-6)-2 proponico dde la mezcla race- mica.

Info

Publication number
ES8204989A1
ES8204989A1 ES498313A ES498313A ES8204989A1 ES 8204989 A1 ES8204989 A1 ES 8204989A1 ES 498313 A ES498313 A ES 498313A ES 498313 A ES498313 A ES 498313A ES 8204989 A1 ES8204989 A1 ES 8204989A1
Authority
ES
Spain
Prior art keywords
salts
compound
physiologically acceptable
preparation
formula see
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498313A
Other languages
English (en)
Other versions
ES498313A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Albert Rolland SA
Original Assignee
Laboratoires Albert Rolland SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Albert Rolland SA filed Critical Laboratoires Albert Rolland SA
Publication of ES8204989A1 publication Critical patent/ES8204989A1/es
Publication of ES498313A0 publication Critical patent/ES498313A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PROCEDIMIENTO PARA LA SEPARACION DE UN ENANTIOMERO DEL ACIDO (FENIL-2 BENZOTIAZOLIL-6)-2 PROPIONICO A PARTIR DE LA MEZCLA RACEMICA. CONSISTE EN HACER REACCIONAR LA MEZCLA RACEMICA DEL ACIDO CON UNA AMINA QUIRAL, TAL COMO UN ENENTIOMERO DE LA A-FENILETILAMINA, PARA OBTRENER UNA MEZCLA DE SALES DIASTEREOISOMERAS; A CONTINUACION SEPARAR UNA DE LAS SALES ASI OBTENIDAS MEDIANTE RECRISTALIZACION EN BUTANONA-2 Y CONVERTIR LA SAL SEPARADA EN EL ACIDO CORRESPONDIENTE POR LA ACCION DEL ACIDO CLORHIDRICO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO INHIBIDORES DE LA BIOSINTESIS DE LAS PROSTAGLANDINAS Y POR SU ACTIVIDAD ANTIAGREGANTE PLAQUETARIA Y ANALGESICA.
ES498313A 1979-04-03 1980-12-11 Procedimiento para la separacion de un enantiomero del acido (fenil-2-benzotiazolil-6)-2 proponico dde la mezcla race- mica. Granted ES498313A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7908303A FR2453163A1 (fr) 1979-04-03 1979-04-03 Derives de benzothiazole, leur procede de preparation et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
ES8204989A1 true ES8204989A1 (es) 1982-06-01
ES498313A0 ES498313A0 (es) 1982-06-01

Family

ID=9223868

Family Applications (2)

Application Number Title Priority Date Filing Date
ES490797A Granted ES490797A0 (es) 1979-04-03 1980-04-01 Procedimiento para la obtencion de derivados de benzotiazol
ES498313A Granted ES498313A0 (es) 1979-04-03 1980-12-11 Procedimiento para la separacion de un enantiomero del acido (fenil-2-benzotiazolil-6)-2 proponico dde la mezcla race- mica.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES490797A Granted ES490797A0 (es) 1979-04-03 1980-04-01 Procedimiento para la obtencion de derivados de benzotiazol

Country Status (27)

Country Link
EP (1) EP0017543B1 (es)
JP (1) JPS55133367A (es)
AR (1) AR227884A1 (es)
AT (1) ATE4807T1 (es)
AU (1) AU530911B2 (es)
BE (1) BE882270A (es)
CA (1) CA1144556A (es)
DD (1) DD151448A5 (es)
DE (1) DE3065004D1 (es)
DK (1) DK134880A (es)
ES (2) ES490797A0 (es)
FI (1) FI801023A (es)
FR (1) FR2453163A1 (es)
GR (1) GR67195B (es)
HU (1) HU178851B (es)
IL (1) IL59655A (es)
IT (1) IT8048308A0 (es)
MA (1) MA18772A1 (es)
NO (1) NO800946L (es)
NZ (1) NZ193337A (es)
OA (1) OA06504A (es)
PH (1) PH15451A (es)
PL (1) PL123701B1 (es)
PT (1) PT71035A (es)
SU (1) SU910120A3 (es)
YU (1) YU80780A (es)
ZA (1) ZA801574B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066546A1 (fr) 2002-02-05 2003-08-14 Sumitomo Chemical Company, Limited Procede de production d'un compose biaryle
CN103209963A (zh) 2010-07-02 2013-07-17 吉里德科学公司 作为hiv抗病毒化合物的2-喹啉基-乙酸衍生物
AP2013006706A0 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc Napht-2-ylacetic acid derivatives to treat AIDS
ES2707997T3 (es) * 2011-04-21 2019-04-08 Gilead Sciences Inc Compuestos de benzotiazol y su uso farmacéutico
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
JP5911638B2 (ja) 2012-04-20 2016-04-27 ギリアード サイエンシーズ， インコーポレイテッド ベンゾチアゾール−６−イル酢酸誘導体およびｈｉｖ感染を処置するためのそれらの使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2145178C3 (de) * 1970-09-11 1975-12-11 Tokyo Tanabe Co., Ltd., Tokio 2-Phenyl-5-oder -6-benzothiazolylessigsäure-Verblndungen
US3895028A (en) * 1972-09-12 1975-07-15 Tokyo Tanabe Co Alpha-(2-phenylbenzothiazol-5-yl)propionic acid

Also Published As

Publication number Publication date
SU910120A3 (ru) 1982-02-28
PL123701B1 (en) 1982-11-30
NO800946L (no) 1980-10-06
DD151448A5 (de) 1981-10-21
ATE4807T1 (de) 1983-10-15
NZ193337A (en) 1982-12-07
EP0017543A1 (fr) 1980-10-15
HU178851B (en) 1982-07-28
IL59655A0 (en) 1980-06-30
MA18772A1 (fr) 1980-10-01
PL223191A1 (es) 1981-01-30
FR2453163A1 (fr) 1980-10-31
AU5686480A (en) 1980-10-09
DK134880A (da) 1980-10-04
YU80780A (en) 1983-02-28
AR227884A1 (es) 1982-12-30
IT8048308A0 (it) 1980-04-01
PT71035A (fr) 1980-04-01
DE3065004D1 (en) 1983-11-03
BE882270A (fr) 1980-09-17
ZA801574B (en) 1981-03-25
OA06504A (fr) 1981-07-31
ES498313A0 (es) 1982-06-01
AU530911B2 (en) 1983-08-04
GR67195B (es) 1981-06-24
EP0017543B1 (fr) 1983-09-28
CA1144556A (en) 1983-04-12
ES8200098A1 (es) 1981-11-01
IL59655A (en) 1983-05-15
FI801023A (fi) 1980-10-04
JPS55133367A (en) 1980-10-17
FR2453163B1 (es) 1982-07-02
ES490797A0 (es) 1981-11-01
PH15451A (en) 1983-01-18

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