ES8201981A1 - Un procedimiento para la preparacion de nuevos derivados de hidantoina - Google Patents

Un procedimiento para la preparacion de nuevos derivados de hidantoina

Info

Publication number
ES8201981A1
ES8201981A1 ES499433A ES499433A ES8201981A1 ES 8201981 A1 ES8201981 A1 ES 8201981A1 ES 499433 A ES499433 A ES 499433A ES 499433 A ES499433 A ES 499433A ES 8201981 A1 ES8201981 A1 ES 8201981A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
hereinbefore defined
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499433A
Other languages
English (en)
Other versions
ES499433A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES499433A0 publication Critical patent/ES499433A0/es
Publication of ES8201981A1 publication Critical patent/ES8201981A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE IDANTIONA DE FORMULA (I), DONDE N ES UN NUMERO ENTERO DE 0 A 5; X ES CO, CS O CH2; Y ES -CH2-CH2-; R1 ES CH2-NR5R6, DONDE R5 Y R6 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-6; R2 ES HIDROGENO O ALQUILO C1-4; R3 ES ALQUILO C1-9, O CILOALQUILO C5-8; R4 ES HIDROGENO O ALQUILO C1-6, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN SOMETER A REACCION DE CICLACION UN COMPUESTO DE FORMULA (II), DONDE R11 ES HIDROXI O HIDROXI PROTEGIDO; R12 ES UN GRUPO ALQUILO C1-6, Y X, Y, R1,R2,R3,R4 Y N TIENE LOS SIGNIFICADOS YA INDICADOS, Y POSTERIORMENTE, SI SE DESEA, CONVERTIR EL COMPUESTO ASI FORMADO, DONDE X ES CS, EN OTRO COMPUESTO, DONDE X ES CH2, Y SE DESEA, CONVERTIR UN GRUPO Y O R4, EN OTRO GRUO DIFERENTE Y O R4, O DESPROTEGER EL GRUPO R11 PROTEGIDO.
ES499433A 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina Expired ES8201981A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7917931 1979-05-23

Publications (2)

Publication Number Publication Date
ES499433A0 ES499433A0 (es) 1982-01-01
ES8201981A1 true ES8201981A1 (es) 1982-01-01

Family

ID=10505375

Family Applications (3)

Application Number Title Priority Date Filing Date
ES491761A Granted ES491761A0 (es) 1979-05-23 1980-05-22 Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES499433A Expired ES8201981A1 (es) 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina
ES499432A Granted ES499432A0 (es) 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES491761A Granted ES491761A0 (es) 1979-05-23 1980-05-22 Un procedimiento para la preparacion de nuevos derivados de hidantoina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499432A Granted ES499432A0 (es) 1979-05-23 1981-02-13 Un procedimiento para la preparacion de nuevos derivados de hidantoina

Country Status (8)

Country Link
US (1) US4315022A (es)
EP (1) EP0020039A1 (es)
JP (1) JPS55162776A (es)
AU (1) AU5862380A (es)
DK (1) DK220680A (es)
ES (3) ES491761A0 (es)
IL (1) IL60040A0 (es)
ZA (1) ZA802765B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496577A (en) * 1983-10-05 1985-01-29 Syntex (U.S.A.) Inc. Imidazolidinone prostaglandins, compositions and use
NO890522L (no) * 1988-02-25 1989-08-28 Bayer Ag Substituerte imidazolinoner og imidazolinthioner.
US6300503B1 (en) * 1999-12-17 2001-10-09 Dixie Chemical Company Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same
DK1765785T3 (da) * 2004-07-02 2009-11-02 Allergan Inc Prostaglandinanaloger
CA2571786A1 (en) * 2004-07-02 2006-02-09 Allergan, Inc. Prostaglandin analogs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204068A (en) * 1976-06-03 1980-05-20 Burroughs Wellcome Co. Nitrogen heterocycles
US4152445A (en) * 1976-12-18 1979-05-01 Beecham Group Limited 1-(3-Hydroxyalk-1-yl)-5-(carboxyalkyl)hydantoin derivatives
AU4778279A (en) * 1978-06-15 1979-12-20 Beecham Group Limited Prostaglandin analogues

Also Published As

Publication number Publication date
ES499433A0 (es) 1982-01-01
ZA802765B (en) 1981-05-27
ES8201980A1 (es) 1982-01-01
US4315022A (en) 1982-02-09
ES499432A0 (es) 1982-01-01
AU5862380A (en) 1980-11-27
EP0020039A1 (en) 1980-12-10
IL60040A0 (en) 1980-07-31
DK220680A (da) 1980-11-24
JPS55162776A (en) 1980-12-18
ES8105302A1 (es) 1981-06-01
ES491761A0 (es) 1981-06-01

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