ES8200646A1 - Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c - Google Patents

Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c

Info

Publication number
ES8200646A1
ES8200646A1 ES498251A ES498251A ES8200646A1 ES 8200646 A1 ES8200646 A1 ES 8200646A1 ES 498251 A ES498251 A ES 498251A ES 498251 A ES498251 A ES 498251A ES 8200646 A1 ES8200646 A1 ES 8200646A1
Authority
ES
Spain
Prior art keywords
substituted
contrast agents
ray contrast
triiodo
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498251A
Other languages
English (en)
Other versions
ES498251A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES8200646A1 publication Critical patent/ES8200646A1/es
Publication of ES498251A0 publication Critical patent/ES498251A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/90—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated
    • C07C233/92—Carboxylic acid amides having nitrogen atoms of carboxamide groups further acylated with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S430/00—Radiation imagery chemistry: process, composition, or product thereof
    • Y10S430/167—X-ray
    • Y10S430/168—X-ray exposure process

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS IONICOS DE ACIDOS 2,4,6-TRIYODO-ISOFALICOS DE FORMULA (I), EN QUE X ES UN RADICAL DE FORMULA (II) U OTROS, E Y ES UN RADICAL DE FORMULA (III), SIENDO R1, R2, R3 Y R4 HIDROGENO O RADICAL ALCOHILO. SE BASA EN LA REACCION DE UN COMPUESTO DE FORMULA (IV) CON UN DERIVADO DE UN ACIDO CARBOXILICO ALIFATICO ACIL-OH. EL COMPUESTO OBTENIDO SE SOMETE A DIAZOTACION CON REACTIVOS TALES COMO ACIDO NITROSO EN MEDIO ACUOSO, U OTROS, A 0-5C; SE MEZCLA CON AGUA Y SE CALIENTA. SE AMIDIFICA PARCIALMENTE POR REACCION CON UN REACTIVO DE CLORACION Y SE CONCENTRA EN VACIO. EL CLORURO DE ACIDO OBTENIDO SE HIDROLIZA, SE ALCOHILA EN NITROGENO O BIEN SE SEPARAN LOS GRUPOS PROTECTORES.
ES498251A 1980-01-11 1980-12-30 Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c Granted ES498251A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803001293 DE3001293A1 (de) 1980-01-11 1980-01-11 Ionische 5-c-substitiuerte 2,4,6-trijod-isophtalsaeure-derivete

Publications (2)

Publication Number Publication Date
ES8200646A1 true ES8200646A1 (es) 1981-12-01
ES498251A0 ES498251A0 (es) 1981-12-01

Family

ID=6092105

Family Applications (3)

Application Number Title Priority Date Filing Date
ES498251A Granted ES498251A0 (es) 1980-01-11 1980-12-30 Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c
ES499408A Expired ES8202538A1 (es) 1980-01-11 1981-02-13 Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c
ES499407A Granted ES499407A0 (es) 1980-01-11 1981-02-13 Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES499408A Expired ES8202538A1 (es) 1980-01-11 1981-02-13 Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c
ES499407A Granted ES499407A0 (es) 1980-01-11 1981-02-13 Procedimiento para la preparacion de derivados ionicos de acidos 2,4,6-triyodo-isoftalicos substituidos en 5-c

Country Status (21)

Country Link
US (1) US4328202A (es)
EP (1) EP0032388B1 (es)
JP (1) JPS56154441A (es)
AT (1) ATE4893T1 (es)
AU (1) AU545757B2 (es)
CA (1) CA1170268A (es)
CS (1) CS223890B2 (es)
DD (1) DD157336A5 (es)
DE (2) DE3001293A1 (es)
DK (1) DK8781A (es)
EG (1) EG15023A (es)
ES (3) ES498251A0 (es)
FI (1) FI804027L (es)
GR (1) GR73104B (es)
HU (1) HU185855B (es)
IE (1) IE50804B1 (es)
IL (1) IL61874A (es)
NO (1) NO152295C (es)
PT (1) PT72327B (es)
YU (2) YU311580A (es)
ZA (1) ZA81148B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US4879349A (en) * 1987-11-05 1989-11-07 Shell Oil Company Selective hydrogenation process
US5001199A (en) * 1987-11-05 1991-03-19 Shell Oil Company Selective hydrogenation process
US4970254A (en) * 1988-09-22 1990-11-13 Shell Oil Company Method for hydrogenating functionalized polymer and products thereof
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
CN103958452B (zh) * 2011-09-29 2016-01-20 陶氏环球技术有限责任公司 原位制备水解酰卤化合物的方法
EP4136068B1 (en) * 2020-04-16 2024-07-10 Basf Se A process for the preparation of 4-cyanobenzoyl chlorides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6777M (es) * 1967-07-10 1969-03-10
IL34803A (en) * 1969-06-27 1975-03-13 Nyegaard & Co As N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them
FR2085636B1 (es) * 1970-04-15 1973-06-08 Guerbet Lab Andre
CH525677A (de) * 1970-05-19 1972-07-31 Eprova Ag Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
GB1539791A (en) * 1976-04-08 1979-02-07 Guerbet Sa X-ray contrast media

Also Published As

Publication number Publication date
ES8202537A1 (es) 1982-02-16
FI804027L (fi) 1981-07-12
ATE4893T1 (de) 1983-10-15
EG15023A (en) 1985-03-31
GR73104B (es) 1984-02-02
YU87783A (en) 1983-12-31
CA1170268A (en) 1984-07-03
ES499407A0 (es) 1982-02-16
EP0032388B1 (de) 1983-10-05
IE50804B1 (en) 1986-07-23
JPS56154441A (en) 1981-11-30
ES499408A0 (es) 1982-02-16
IL61874A (en) 1984-06-29
AU6609581A (en) 1981-07-16
ZA81148B (en) 1982-01-27
CS223890B2 (en) 1983-11-25
HU185855B (en) 1985-04-28
YU311580A (en) 1983-10-31
DE3161052D1 (en) 1983-11-10
ES8202538A1 (es) 1982-02-16
IL61874A0 (en) 1981-02-27
PT72327B (en) 1981-12-18
EP0032388A1 (de) 1981-07-22
US4328202A (en) 1982-05-04
JPH0128011B2 (es) 1989-05-31
ES498251A0 (es) 1981-12-01
DE3001293A1 (de) 1981-07-16
NO810070L (no) 1981-07-13
NO152295C (no) 1985-09-04
AU545757B2 (en) 1985-08-01
IE810034L (en) 1981-07-11
PT72327A (de) 1981-02-01
NO152295B (no) 1985-05-28
DD157336A5 (de) 1982-11-03
DK8781A (da) 1981-07-12

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