ES8200080A1 - Un procedimiento para la preparacion de un nuevo peptido. - Google Patents
Un procedimiento para la preparacion de un nuevo peptido.Info
- Publication number
- ES8200080A1 ES8200080A1 ES495517A ES495517A ES8200080A1 ES 8200080 A1 ES8200080 A1 ES 8200080A1 ES 495517 A ES495517 A ES 495517A ES 495517 A ES495517 A ES 495517A ES 8200080 A1 ES8200080 A1 ES 8200080A1
- Authority
- ES
- Spain
- Prior art keywords
- long lasting
- lhrh
- agonists
- antagonists
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN PEPTIDO DE FORMULA (I), DONDE A, B, C, D, E, F, G, X E Y PUEDEN SER DIFIRENTES RADICALES Y "N" ES 2 O 3. SE SOMETE A REACCION DE ALQUILACION UN COMPUESTO DE FORMULA (II), DONDE R3 ES ALQUILO, PARA OBTENER UNA SAL DE SULFONILO. DICHA SAL SE HACE REACCIONAR CON UNA BASE FUERTE PARA OBTENER UN COMPUESTO DE FORMULA (III). ESTE COMPUESTO SE HACE REACCIONAR CON OTRO DE FORMULA H-F-G-X- Y POSTERIORMENTE SE SOMETE A REACCION DE DESBLOQUEO. EL PRODUCTO ASI OBTENIDO SE HACE REACCIONAR, POR ULTIMO, CON UN COMPUESTO DE FORMULA A-B-C-D-E-OH PARA OBTENER EL PEPTIDO DE FORMULA (I). DE APLICACION EN COMPOSICIONES FARMACEUTICAS PARA PROMOVER Y REDUCIR LA FERTILIDAD .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/080,844 US4377515A (en) | 1979-10-01 | 1979-10-01 | Long lasting agonists and antagonists of LH-RH |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8200080A1 true ES8200080A1 (es) | 1981-10-16 |
ES495517A0 ES495517A0 (es) | 1981-10-16 |
Family
ID=22159985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES495517A Granted ES495517A0 (es) | 1979-10-01 | 1980-09-30 | Un procedimiento para la preparacion de un nuevo peptido. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4377515A (es) |
EP (1) | EP0026640B1 (es) |
JP (1) | JPS56115753A (es) |
AT (1) | ATE6638T1 (es) |
DE (1) | DE3067002D1 (es) |
DK (1) | DK413580A (es) |
ES (1) | ES495517A0 (es) |
GR (1) | GR70026B (es) |
IE (1) | IE50298B1 (es) |
PT (1) | PT71861B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR74635B (es) * | 1980-08-18 | 1984-06-29 | Merck & Co Inc | |
PT73522B (en) * | 1980-08-18 | 1983-07-14 | Merck & Co Inc | Process for preparing substituted caprylolactam derivatives as antihypertensives |
IL63540A0 (en) * | 1980-08-18 | 1981-11-30 | Merck & Co Inc | Substituted enantholactam derivatives as antihypertensives |
US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
IT1178775B (it) * | 1983-12-23 | 1987-09-16 | Konzponti Valto Es Hitelbank R | Derivati della gonadoliberina e procedimento per la loro preparazione |
US4659691A (en) * | 1985-02-08 | 1987-04-21 | Merck & Co., Inc. | Novel cyclic Hexapeptide LHRH antagonists |
US4677193A (en) * | 1985-02-22 | 1987-06-30 | The Salk Institute For Biological Studies | Peptides containing an aliphatic-aromatic ketone side chain |
HU194280B (en) * | 1985-10-22 | 1988-01-28 | Richter Gedeon Vegyeszet | Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them |
HU194913B (en) * | 1986-01-03 | 1988-03-28 | Innofinance Altalanos Innovaci | Process for producing novel gonadoliberin derivatives containing in the sixth position aromatic amino carboxylic acid and medical preparations containing these compounds |
US4762717A (en) * | 1986-03-21 | 1988-08-09 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use as a contraceptive |
US4761398A (en) * | 1986-08-18 | 1988-08-02 | Embrex, Inc. | Method of inducing birds to molt |
GB8807427D0 (en) * | 1988-03-28 | 1988-05-05 | National Biological Standards Board | Peptides |
EP0335662B1 (en) * | 1988-03-28 | 1995-07-26 | Btg International Limited | Peptides |
US5942489A (en) * | 1996-05-03 | 1999-08-24 | The Administrators Of The Tulane Educational Fund | HGH-RH(1-29)NH2 analogues having antagonistic activity |
EP0842946A1 (en) * | 1996-11-14 | 1998-05-20 | Laboratoire Theramex S.A. | Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them |
GB9809021D0 (en) | 1998-04-29 | 1998-06-24 | Zeneca Ltd | Chemical process |
DE19841895A1 (de) * | 1998-09-11 | 2000-03-23 | Degussa | Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS50142563A (es) * | 1974-04-26 | 1975-11-17 | ||
DE2617646C2 (de) * | 1976-04-22 | 1986-07-31 | Hoechst Ag, 6230 Frankfurt | Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
-
1979
- 1979-10-01 US US06/080,844 patent/US4377515A/en not_active Expired - Lifetime
-
1980
- 1980-09-25 DE DE8080303370T patent/DE3067002D1/de not_active Expired
- 1980-09-25 EP EP80303370A patent/EP0026640B1/en not_active Expired
- 1980-09-25 AT AT80303370T patent/ATE6638T1/de not_active IP Right Cessation
- 1980-09-29 GR GR62988A patent/GR70026B/el unknown
- 1980-09-30 DK DK413580A patent/DK413580A/da not_active Application Discontinuation
- 1980-09-30 IE IE2039/80A patent/IE50298B1/en unknown
- 1980-09-30 ES ES495517A patent/ES495517A0/es active Granted
- 1980-10-01 JP JP13751380A patent/JPS56115753A/ja active Granted
- 1980-10-01 PT PT71861A patent/PT71861B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
EP0026640A2 (en) | 1981-04-08 |
JPS6210519B2 (es) | 1987-03-06 |
DK413580A (da) | 1981-04-02 |
PT71861B (en) | 1982-03-31 |
EP0026640B1 (en) | 1984-03-14 |
ES495517A0 (es) | 1981-10-16 |
IE802039L (en) | 1981-04-01 |
JPS56115753A (en) | 1981-09-11 |
DE3067002D1 (en) | 1984-04-19 |
EP0026640A3 (en) | 1981-08-05 |
IE50298B1 (en) | 1986-03-19 |
US4377515A (en) | 1983-03-22 |
PT71861A (en) | 1980-11-01 |
GR70026B (es) | 1982-07-23 |
ATE6638T1 (de) | 1984-03-15 |
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