ES8302675A1 - "procedimiento para la preparacion de 1,2 benzisoxazoloxietilaminas". - Google Patents
"procedimiento para la preparacion de 1,2 benzisoxazoloxietilaminas".Info
- Publication number
- ES8302675A1 ES8302675A1 ES509761A ES509761A ES8302675A1 ES 8302675 A1 ES8302675 A1 ES 8302675A1 ES 509761 A ES509761 A ES 509761A ES 509761 A ES509761 A ES 509761A ES 8302675 A1 ES8302675 A1 ES 8302675A1
- Authority
- ES
- Spain
- Prior art keywords
- benzisoxazoloxyethylamines
- intermediates
- preparation
- diuretics
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1,2-BENCISOXAZOLOXIETILAMINAS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS RADICALES; R , R Y R SON HIDROGENO, HALOGENO O METILO; Y R Y R SON HIDROGENO O ALCOHILO INFERIOR. CONSISTE ESENCIALMENTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON HIDRAZINA, EN UN DISOLVENTE INERTE, A LA TEMPERATURA DE REFLUJO DE LA MEZCLA DE REACCION. SI R Y R SON DISTINTOS DE HIDROGENO, EL COMPUESTO FORMADO SE SOMETE A ACILACION CON UN ACIDO O ANHIDRIDO ALCANOICO ADECUADO. ESTOS COMPUESTOS TIENEN APLICACIONES COMO AGENTES DIURETICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/238,276 US4427691A (en) | 1981-02-25 | 1981-02-25 | 1,2-Benzisoxazoloxyethylamines and intermediates for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8302675A1 true ES8302675A1 (es) | 1983-01-16 |
ES509761A0 ES509761A0 (es) | 1983-01-16 |
Family
ID=22897214
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509761A Granted ES509761A0 (es) | 1981-02-25 | 1982-02-19 | "procedimiento para la preparacion de 1,2 benzisoxazoloxietilaminas". |
Country Status (4)
Country | Link |
---|---|
US (1) | US4427691A (es) |
EP (1) | EP0058977A1 (es) |
JP (1) | JPS57156470A (es) |
ES (1) | ES509761A0 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4452804A (en) * | 1981-02-25 | 1984-06-05 | Hoechst-Roussel Pharmaceuticals Inc. | 1,2-Benzisoxazoloxyethylamines and intermediates for the preparation thereof |
US4504669A (en) * | 1981-02-25 | 1985-03-12 | Hoechst-Roussel Pharmaceuticals Inc. | 1,2-Benzisoxazoloxyethylamines and intermediates for the preparation thereof |
US4602028A (en) * | 1983-12-14 | 1986-07-22 | Hoechst-Roussel Pharmaceuticals, Inc. | Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids |
US4738709A (en) * | 1985-01-10 | 1988-04-19 | Ppg Industries, Inc. | Herbicidally active substituted benzisoxazoles |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
US7125865B2 (en) * | 2002-07-25 | 2006-10-24 | Merck & Co., Inc. | Therapeutic compounds for treating dyslipidemic conditions |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1915644U (de) | 1965-02-26 | 1965-05-13 | Dingerkus Geb | Metalltopf. |
US3539584A (en) | 1967-11-14 | 1970-11-10 | Colgate Palmolive Co | 5-substituted-2,1-benzisothiazolines |
GB1265824A (es) * | 1968-03-28 | 1972-03-08 | ||
US3642897A (en) | 1968-12-26 | 1972-02-15 | Sandoz Ag | Preparation of 2-alkylaminobenzophenones |
JPS5545545B2 (es) | 1972-03-17 | 1980-11-18 | ||
GB1513446A (en) | 1975-09-09 | 1978-06-07 | Shionogi & Co | 1,2-benzisoxazole derivatives |
ES475100A1 (es) * | 1977-11-21 | 1979-12-01 | Hoechst Ag | Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos |
FR2431491A1 (fr) * | 1978-07-18 | 1980-02-15 | Delalande Sa | Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique |
-
1981
- 1981-02-25 US US06/238,276 patent/US4427691A/en not_active Expired - Fee Related
-
1982
- 1982-02-19 ES ES509761A patent/ES509761A0/es active Granted
- 1982-02-20 EP EP82101318A patent/EP0058977A1/en not_active Withdrawn
- 1982-02-24 JP JP57027546A patent/JPS57156470A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US4427691A (en) | 1984-01-24 |
EP0058977A1 (en) | 1982-09-01 |
JPS57156470A (en) | 1982-09-27 |
ES509761A0 (es) | 1983-01-16 |
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