ES8107168A1 - Procedimiento para preparar derivados bencilidenicos en for-ma sin, anti o mezcla sin-anti - Google Patents

Procedimiento para preparar derivados bencilidenicos en for-ma sin, anti o mezcla sin-anti

Info

Publication number
ES8107168A1
ES8107168A1 ES497146A ES497146A ES8107168A1 ES 8107168 A1 ES8107168 A1 ES 8107168A1 ES 497146 A ES497146 A ES 497146A ES 497146 A ES497146 A ES 497146A ES 8107168 A1 ES8107168 A1 ES 8107168A1
Authority
ES
Spain
Prior art keywords
hydrogen
formula
image
allyl
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497146A
Other languages
English (en)
Other versions
ES497146A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES497146A0 publication Critical patent/ES497146A0/es
Publication of ES8107168A1 publication Critical patent/ES8107168A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS BENCILIDENICOS EN FORMA SIN, ANTI O MEZCLA SIN/ANTI, DE FORMULA (I), DONDE "N" Y "M" SON ENTEROS DE 1 A 3; R1 Y R2 SON HIDROGENO O HALOGENO; R3, R4 Y R5 SON HIDROGENO O ALCOHILO, Y R6 ES UN GRUPO AMINO, ALCOHILAMINO, HIDROXIALCOHILAMINO O UN HETEROCIDO NITROGENADO. SE HACE REACCIONAR UNA BENZOFENONA DE FORMULA (II) CON ETANOLAMINA A UNA TEMPERATURA COMPRENDIDA ENTRE 100 Y 140GC Y SE OBTIENE UN COMPUESTO HIDROXILADO DE FORMULA (III). ESTE COMPUESTO SE HACE REACCIONAR CON UN COMPUESTO AMINADO DE FORMULA (IV), A UNA TEMPERATURA DE 20 A 150GC, Y EN UN DISOLVENTE POLAR PARA OBTENER EL COMPUESTO DE FORMULA (I). DE APLICACION POR SUS PROPIEDADES ANTICONVULSIVAS ANTISIOLITICAS. *FORMULA* E
ES497146A 1979-11-27 1980-11-26 Procedimiento para preparar derivados bencilidenicos en for-ma sin, anti o mezcla sin-anti Expired ES8107168A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7929139A FR2470116A1 (fr) 1979-11-27 1979-11-27 Derives benzylideniques, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES497146A0 ES497146A0 (es) 1981-10-01
ES8107168A1 true ES8107168A1 (es) 1981-10-01

Family

ID=9232118

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497146A Expired ES8107168A1 (es) 1979-11-27 1980-11-26 Procedimiento para preparar derivados bencilidenicos en for-ma sin, anti o mezcla sin-anti

Country Status (20)

Country Link
JP (1) JPS5692852A (es)
AT (1) AT372077B (es)
AU (1) AU535262B2 (es)
BE (1) BE886361A (es)
CA (1) CA1145760A (es)
DE (1) DE3044542A1 (es)
DK (1) DK503180A (es)
ES (1) ES8107168A1 (es)
FR (1) FR2470116A1 (es)
GB (1) GB2063867B (es)
GR (1) GR72133B (es)
IL (1) IL61568A (es)
IT (1) IT1134469B (es)
LU (1) LU82958A1 (es)
NL (1) NL8006427A (es)
NO (1) NO803561L (es)
NZ (1) NZ195654A (es)
PT (1) PT72114B (es)
SE (1) SE8008279L (es)
ZA (1) ZA807389B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8220421A (nl) * 1982-07-30 1984-06-01 Inst Organicheskogo Sinteza Ak Condensatieprodukten van alfa-aminoisopropylfenylketon bij de carbonyl c=o binding met gesubstitueerde amines van functioneel gesubstitueerde hydrazines of met derivaten van in de natuur voorkomende aminozuren, die een antitumoractiviteit hebben.
US5278191A (en) * 1988-08-31 1994-01-11 G. D. Searle & Co. Diphenylmethylaminoacetamide derivatives as anti-convulsants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1497456A (fr) * 1964-06-15 1967-10-13 Clin Byla Ets Ortho-amino aryl cétimines, composés hétérocycliques qui s'y rattachent et prépaation de ces divers corps

Also Published As

Publication number Publication date
BE886361A (fr) 1981-05-26
IT8026247A0 (it) 1980-11-26
GB2063867A (en) 1981-06-10
AT372077B (de) 1983-08-25
FR2470116A1 (fr) 1981-05-29
IT1134469B (it) 1986-08-13
ZA807389B (en) 1981-11-25
ES497146A0 (es) 1981-10-01
PT72114B (fr) 1981-09-29
NO803561L (no) 1981-05-29
JPS5692852A (en) 1981-07-27
SE8008279L (sv) 1981-05-28
PT72114A (fr) 1980-12-01
NZ195654A (en) 1982-05-31
AU6473080A (en) 1981-06-04
DK503180A (da) 1981-05-28
NL8006427A (nl) 1981-07-01
AU535262B2 (en) 1984-03-08
GR72133B (es) 1983-09-19
CA1145760A (en) 1983-05-03
GB2063867B (en) 1983-09-14
ATA577780A (de) 1983-01-15
IL61568A (en) 1984-12-31
IL61568A0 (en) 1980-12-31
DE3044542A1 (de) 1981-09-03
LU82958A1 (fr) 1982-06-30
FR2470116B1 (es) 1983-07-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001