ES8106492A1 - Procedimiento para preparar compuestos de 3-metilemazetidina - Google Patents
Procedimiento para preparar compuestos de 3-metilemazetidinaInfo
- Publication number
- ES8106492A1 ES8106492A1 ES493499A ES493499A ES8106492A1 ES 8106492 A1 ES8106492 A1 ES 8106492A1 ES 493499 A ES493499 A ES 493499A ES 493499 A ES493499 A ES 493499A ES 8106492 A1 ES8106492 A1 ES 8106492A1
- Authority
- ES
- Spain
- Prior art keywords
- methyleneazetidine
- derivatives
- compound
- methyleneazetidines
- diphenylmethyleneazetidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KSMPVQGZQQURBU-UHFFFAOYSA-N 3-methylideneazetidine Chemical class C=C1CNC1 KSMPVQGZQQURBU-UHFFFAOYSA-N 0.000 title abstract 2
- MKJIEFSOBYUXJB-HOCLYGCPSA-N (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Chemical compound C1CN2C[C@H](CC(C)C)C(=O)C[C@H]2C2=C1C=C(OC)C(OC)=C2 MKJIEFSOBYUXJB-HOCLYGCPSA-N 0.000 abstract 1
- FTNOJINZWIALRG-UHFFFAOYSA-N 3-benzhydrylidene-1-propan-2-ylazetidine;oxalic acid Chemical compound OC(=O)C(O)=O.C1N(C(C)C)CC1=C(C=1C=CC=CC=1)C1=CC=CC=C1 FTNOJINZWIALRG-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-methyleneazetidine compound Chemical class 0.000 abstract 1
- 206010015995 Eyelid ptosis Diseases 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003028 elevating effect Effects 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 201000003004 ptosis Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229960005333 tetrabenazine Drugs 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/059,093 US4260606A (en) | 1979-07-19 | 1979-07-19 | 3-Methyleneazetidine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8106492A1 true ES8106492A1 (es) | 1981-07-01 |
| ES493499A0 ES493499A0 (es) | 1981-07-01 |
Family
ID=22020806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493499A Granted ES493499A0 (es) | 1979-07-19 | 1980-07-18 | Procedimiento para preparar compuestos de 3-metilemazetidina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4260606A (en:Method) |
| JP (1) | JPS5625152A (en:Method) |
| AU (1) | AU538139B2 (en:Method) |
| BE (1) | BE884356A (en:Method) |
| CH (1) | CH647233A5 (en:Method) |
| DE (1) | DE3027169A1 (en:Method) |
| ES (1) | ES493499A0 (en:Method) |
| FR (1) | FR2461699A1 (en:Method) |
| GB (1) | GB2055818B (en:Method) |
| HK (1) | HK285A (en:Method) |
| HU (1) | HU184806B (en:Method) |
| IE (1) | IE50015B1 (en:Method) |
| IL (1) | IL60376A (en:Method) |
| IT (1) | IT1141608B (en:Method) |
| NL (1) | NL8004163A (en:Method) |
| PT (1) | PT71582A (en:Method) |
| SE (1) | SE448994B (en:Method) |
| SG (1) | SG26184G (en:Method) |
| ZA (1) | ZA803777B (en:Method) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540690A (en) * | 1982-02-09 | 1985-09-10 | The Upjohn Company | 2-(Phenylmethylene)cycloalkylamines and -azetidines |
| US4652559A (en) * | 1982-08-16 | 1987-03-24 | The Upjohn Company | 2-(Phenylmethylene)cycloalkyl-azetidines |
| JPS6086358U (ja) * | 1983-11-21 | 1985-06-14 | 積水化成品工業株式会社 | 柔道用マツト |
| DE4445322A1 (de) * | 1994-12-19 | 1996-06-20 | Trw Repa Gmbh | Kraftbegrenzer für Fahrzeug-Sicherheitsgurtsysteme |
| FR2783246B1 (fr) * | 1998-09-11 | 2000-11-17 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les medicaments les contenant |
| IL141769A0 (en) | 1998-09-11 | 2002-03-10 | Aventis Pharma Sa | Azetidine derivatives, preparation and medicines containing them |
| US6479479B2 (en) * | 2000-03-03 | 2002-11-12 | Aventis Pharma S.A. | Azetidine derivatives, their preparation and pharmaceutical compositions containing them |
| EP2341912B1 (en) | 2008-09-05 | 2014-01-22 | Supernus Pharmaceuticals, Inc. | Method of treatment of attention deficit/hyperactivity disorder (adhd) |
| WO2010127120A1 (en) * | 2009-04-30 | 2010-11-04 | Supernus Pharmaceuticals, Inc. | Method of treatment of depression |
| JP6290100B2 (ja) | 2012-02-08 | 2018-03-07 | スパーナス ファーマシューティカルズ インコーポレイテッド | ビロキサジンの緩和放出製剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481920A (en) * | 1965-10-22 | 1969-12-02 | Lilly Co Eli | Azetidinones |
| US3458635A (en) * | 1966-08-08 | 1969-07-29 | Robins Co Inc A H | Compositions containing 3-di-substituted methylene pyrrolidines and methods of treating depression |
| US3494964A (en) * | 1969-01-13 | 1970-02-10 | Lilly Co Eli | Alpha-halo-alpha-amino ketones |
| US3732247A (en) * | 1970-08-14 | 1973-05-08 | Robins Co Inc A H | 3-di-substituted methylene pyrrolidines wherein the 1-or n-lower-alkyl substituent contains at least two carbon atoms |
| US4002766A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | Antiarrhythmia methods |
| US4078073A (en) * | 1975-01-24 | 1978-03-07 | Carlo Erba S.P.A. | N-tricyclic derivatives of azetidine |
| US4118499A (en) * | 1975-10-15 | 1978-10-03 | Glaxo Laboratories Limited | Anti-anxiety and anti-parkinsonian 1-aminoalkyl-2-endo-chloro-7,7-dimethylnorbornanes |
| US4065573A (en) * | 1976-06-03 | 1977-12-27 | The Upjohn Company | 4-Amino-4-phenylcyclohexanone ketal compositions and process of use |
| US4133881A (en) * | 1977-04-27 | 1979-01-09 | A. H. Robins Company, Incorporated | Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods |
-
1979
- 1979-07-19 US US06/059,093 patent/US4260606A/en not_active Expired - Lifetime
-
1980
- 1980-06-23 IL IL60376A patent/IL60376A/xx unknown
- 1980-06-25 ZA ZA00803777A patent/ZA803777B/xx unknown
- 1980-07-14 GB GB8022966A patent/GB2055818B/en not_active Expired
- 1980-07-17 SE SE8005236A patent/SE448994B/sv not_active IP Right Cessation
- 1980-07-17 DE DE19803027169 patent/DE3027169A1/de not_active Withdrawn
- 1980-07-17 IE IE1487/80A patent/IE50015B1/en unknown
- 1980-07-17 BE BE0/201438A patent/BE884356A/fr not_active IP Right Cessation
- 1980-07-17 FR FR8015841A patent/FR2461699A1/fr active Granted
- 1980-07-18 NL NL8004163A patent/NL8004163A/nl not_active Application Discontinuation
- 1980-07-18 AU AU60618/80A patent/AU538139B2/en not_active Ceased
- 1980-07-18 HU HU801813A patent/HU184806B/hu unknown
- 1980-07-18 IT IT68155/80A patent/IT1141608B/it active
- 1980-07-18 ES ES493499A patent/ES493499A0/es active Granted
- 1980-07-18 CH CH5526/80A patent/CH647233A5/fr not_active IP Right Cessation
- 1980-07-18 PT PT71582A patent/PT71582A/pt unknown
- 1980-07-19 JP JP9927480A patent/JPS5625152A/ja active Granted
-
1984
- 1984-03-27 SG SG261/84A patent/SG26184G/en unknown
-
1985
- 1985-01-03 HK HK2/85A patent/HK285A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK285A (en) | 1985-01-11 |
| AU538139B2 (en) | 1984-08-02 |
| CH647233A5 (fr) | 1985-01-15 |
| SE8005236L (sv) | 1981-01-20 |
| JPS5625152A (en) | 1981-03-10 |
| IL60376A0 (en) | 1980-09-16 |
| ES493499A0 (es) | 1981-07-01 |
| US4260606A (en) | 1981-04-07 |
| SG26184G (en) | 1985-03-29 |
| JPS6328906B2 (en:Method) | 1988-06-10 |
| HU184806B (en) | 1984-10-29 |
| IT1141608B (it) | 1986-10-01 |
| ZA803777B (en) | 1981-09-30 |
| FR2461699A1 (fr) | 1981-02-06 |
| DE3027169A1 (de) | 1981-02-19 |
| IT8068155A0 (it) | 1980-07-18 |
| NL8004163A (nl) | 1981-01-21 |
| FR2461699B1 (en:Method) | 1983-04-22 |
| IE50015B1 (en) | 1986-01-22 |
| PT71582A (en) | 1980-08-01 |
| GB2055818A (en) | 1981-03-11 |
| IL60376A (en) | 1983-07-31 |
| SE448994B (sv) | 1987-03-30 |
| AU6061880A (en) | 1981-01-22 |
| BE884356A (fr) | 1980-11-17 |
| GB2055818B (en) | 1983-06-22 |
| IE801487L (en) | 1981-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |